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Vol. 88. Issue 4.
Pages 127-129 (April 2013)
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Vol. 88. Issue 4.
Pages 127-129 (April 2013)
Original article
Analysis of factors that determine the diagnostic yield of temporal artery biopsy
Factores modificadores de la rentabilidad de la biopsia de arteria temporal
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1162
A.M. Suelvesa,
Corresponding author
ana.suelves@gmail.com

Corresponding author.
, E. España-Gregoria,b, J. Aviñóa, S. Rohrwecka, M. Díaz-Llopisa,c,d
a Servicio de Oftalmología, Hospital Universitario La Fe, Valencia, Spain
b Departamento de Óptica, Universidad de Valencia, Valencia, Spain
c Facultad de Medicina, Universidad de Valencia, Valencia, Spain
d CIBERER, Ciber de enfermedades raras, Valencia, Spain
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Tables (4)
Table 1. Baseline characteristics of patients included in the study.
Table 2. Temporal artery biopsy results based on main symptom.
Table 3. Diagnostics in the negative temporal artery biopsy group.
Table 4. Variables predicting positive biopsy.
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Abstract
Purpose

To analyze the diagnostic yield of temporal artery biopsy in the diagnosis of giant cell arteritis, and to correlate these results with the clinical and laboratory features which indicate it, in an attempt to increase the efficiency of this technique and try to “save biopsies”.

Methods

A retrospective cohort study including suspected giant cell arteritis cases in which a temporal artery biopsy was performed. The data recorded included demographic, clinical and laboratory information.

Results

A total of 38 patients were analyzed. The biopsy was positive in 68.42% of cases. Multivariate analysis revealed visual symptoms and a high C-reactive protein as parameters with a high diagnostic efficiency.

Conclusions

Our study supports the fact that temporal artery biopsy should be undertaken when there is strong clinical suspicion. Visual symptoms and high C-reactive protein are considered as high efficiency indicators to biopsy.

Keywords:
Temporal artery biopsy
Giant cell arteritis
Horton's arteritis
Ischaemic optic neuropathy
Diagnosis
Resumen
Propósito

Analizar la rentabilidad diagnóstica de la biopsia de la arteria temporal (BAT) en la arteritis de células gigantes (ACG) y correlacionar su resultado con hallazgos clínicos y analíticos que establecen la indicación para aumentar la rentabilidad diagnóstica de esta técnica y valorar posibles parámetros «ahorradores de biopsias».

Métodos

Estudio de cohortes retrospectivo de casos con sospecha de ACG en los que se realizaron BAT. Se recogieron datos demográficos, clínicos, analíticos.

Resultados

Se analizaron datos en 38 pacientes. La biopsia fue positiva en el 68,42% de los casos. En un análisis multivariante se determinaron los síntomas visuales específicos y la proteína C reactiva (PCR) como predictores de una BAT positiva con significación estadística.

Conclusiones

Nuestros datos apoyan que el diagnóstico de ACG mediante la BAT debe basarse en una alta sospecha clínica. Los síntomas visuales y PCR elevada destacan en nuestra serie como parámetros con alta rentabilidad diagnóstica.

Palabras clave:
Biopsia de arteria temporal
Arteritis de células gigantes
Arteritis de Horton
Neuritis óptica isquémica
Rentabilidad diagnóstica

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