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Inicio Annals of Hepatology P-27 ALTERATION IN LIVER FUNCTION TESTS AMONG PATIENTS HOSPITALIZED FOR COVID-19...
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Vol. 24. Núm. S1.
Abstracts of the 2021 Annual meeting of the ALEH (Asociación Latinoamericana para el Estudio del Hígado)
(septiembre 2021)
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Vol. 24. Núm. S1.
Abstracts of the 2021 Annual meeting of the ALEH (Asociación Latinoamericana para el Estudio del Hígado)
(septiembre 2021)
Open Access
P-27 ALTERATION IN LIVER FUNCTION TESTS AMONG PATIENTS HOSPITALIZED FOR COVID-19: A MULTICENTRIC STUDY IN PERU
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Ivania Marín Dueñas1, Jenny Vega1, Hugo Carrillo-Ng1, Isabel Veramendi-Schult2, Ricardo Zavaleta Alva2, Luis Vásquez3, Zeneida Gonzales-Soler4, Hellen Agurto-Lescano5, Jorge Garavito Rentería1, Adelina Lozano1
1 Universidad Peruana Cayetano Heredia, Unidad de Hígado, Hospital Nacional Arzobispo Loayza
2 Hospital Hipólito Unanue
3 Hospital Santa Rosa – Piura
4 Hospital Cayetano Heredia – Piura
5 Clínica Sanna San Borja
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Vol. 24. Núm S1

Abstracts of the 2021 Annual meeting of the ALEH (Asociación Latinoamericana para el Estudio del Hígado)

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Introduction

COVID-19 affects the liver, causing alteration in liver biochemistry tests such as aspartate transferase (AST), alanine transferase (ALT), alkaline phosphatase (ALP), total bilirubin and albumin.

Objective

To determine the prevalence of alteration in liver functions tests and associated factors for severity among peruvian COVID-19 patients.

Methods

A descriptive, retrospective and cross-sectional study was performed in 4 public hospitals in Peru. Patients admitted to hospitalization wards and intensive care units with a diagnosis COVID-19 were enrolled. The evaluation of AST, ALT, ALP, total bilirrubin and albumin was performed. Associations with demographic and medical data were assessed.

Results

1100 patients were enrolled, of which 81.7% had altered liver function tests. Only 2.8% of the patients had cirrhosis and 2.1% hepatitis B/C virus. AST and ALT were altered at admission in 64.7% and 63.7%, of the patients respectively. Factors associated with liver injury were: being female OR=0.53 (95% CI: 0.39-0.73; p<0.01), dyslipidemia OR=1.72 (95% CI: 1.10-2.70; p=0.01), previous medication OR=1.56 (95% CI: 1.12 -2.16, p<0.01) and fever OR=1.43 (95% CI: 1.03-1.199, p=0.03). Disease severity was associated with levels of AST and ALT (p<0.01). Patients taking self-medication OR=1.56 (95% CI: 1.12-2.16; p<0.01) and paracetamol OR= 1.41 (95% CI:1.01-1.98; p=0.04) had higher risk of liver injury. Meanwhile, corticosteroids OR=0.55 (95% CI: 0.38-0.78; p<0.01) and enoxaparin OR=0.53 (95% CI: 0.35-0.81; p<0.01) were protective factors.

Conclusions

Peruvian patients with COVID-19 presented high prevalence of alteration in liver function tests, high levels of AST and ALT were related to disease severity.

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