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Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial
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Inicio Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial Tratamento Medicamentoso de Lesões Iniciais de Cárie
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Vol. 50. Issue 1.
Pages 43-51 (January - February 2009)
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Vol. 50. Issue 1.
Pages 43-51 (January - February 2009)
Revisão
Open Access
Tratamento Medicamentoso de Lesões Iniciais de Cárie
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Esmeralda Costa*, Joana Domingues**, João Cardoso Ferreira***, Paulo Melo****
* Mestre em Medicina Dentária Conservadora - Endodontia, Faculdade de Medicina Dentária da Universidade do Porto, Porto
** Mestre em Medicina Dentária Conservadora, Docente do Curso de Medicina Dentária da Universidade Fernando Pessoa, Porto
*** Mestre em Medicina Dentária Conservadora pela FMDUP, Docente voluntário de Dentisteria Operatória Faculdade de Medicina Dentária da Universidade do Porto, Porto
**** Professor Associado de Dentisteria Operatória Faculdade de Medicina Dentária da Universidade do Porto, Porto
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Resumo

O tratamento medicamentoso das lesões iniciais de cárie, pode evitar a necessidade de procedimentos cirúrgicos. A progressão da doença pode ser controlada, ou mesmo eliminada, se forem criadas condições favoráveis que possibilitem a remineralização. Este trabalho tem por objectivo apresentar uma revisão dos agentes terapêuticos remineralizantes disponíveis actualmente para o tratamento das lesões de cárie iniciais.

Material e métodos

Efectuou-se a consulta dos artigos disponíveis nas bases de dados: Cochrane Central Register of Controlled Trials, Current Contents, Journal Citation Reports, Pubmed, Science Direct e ISI Web of Science. Utilizaram-se como critérios de selecção: estudos publicados desde Janeiro de 2000 até Dezembro de 2007 e estudos referentes ao tratamento (reversão ou redução da progressão) da cárie dentária.

Resultados

Foram identificados 207 artigos, tendo apenas 42 correspondido aos critérios de inclusão. O flúor e a caseína são os principais agentes terapêuticos disponíveis para o tratamento das lesões de cárie iniciais. Pastas dentífricas, soluções fluoretadas para bochechos, geles, vernizes, pastilhas elásticas e dispositivos intra-orais libertadores de flúor, são os meios mais utilizados para tratamento das lesões de cárie iniciais. Os fosfopeptídeos de caseína inibem a desmineralização e promovem a remineralização das lesões do esmalte em profundidade.

Conclusão

Devido à potencial reversibilidade das lesões de cárie iniciais, o diagnóstico precoce dos sinais de desmineralização e actividade da doença é fundamental para evitar o tratamento cirúrgico dessas lesões. O flúor e a caseína nas diferentes formas de aplicação tópica demonstraram de facto, ser bastante eficazes em inibir a desmineralização e em favorecer a remineralização.

Palavras-Chave:
Cárie dentária
Cáries incipientes
Lesões iniciais de cárie
Remineralização
Flúor
Caseína
Abstract

The medical treatment of initial caries lesions can prevent the necessity of surgical procedures. The progression of the disease can be controlled, or eliminated, if favourable conditions that make possible the remineralisation process are present. The aim of this work is to present a revision of the available remineralizing agents for the treatment of the initial caries lesions.

Material and methods

It was made a Journal database paper review in: Central Cochrane Register of Controlled Trials, Current Contents, Journal Citation Reports, Pubmed, Science Direct and ISI Web of Science. The selection criteria were: papers published since January of 2000 until December of 2007 and referring studies to dental caries treatment (reversion or reduction of the progression).

Results

207 articles were identified, but only 42 had corresponded to the inclusion criteria. The fluoride and the casein are the main available therapeutical agents for the treatment of the initial caries lesions. Dentifrices, mouthwashes solutions, gels, varnishes, tablets and delivery fluoride intra-oral devices, are the most used agents for initial caries lesions treatment. The casein phosphopeptides inhibit demineralization and promote remineralization of the enamel lesions in depth.

Conclusion

Due to potential reversibility of the initial caries lesions, the early demineralization and carious activity diagnosis are essential to prevent the surgical treatment of these lesions. The fluoride and the casein in the different topic application forms had demonstrated being sufficiently efficient in inhibiting the demineralization and favouring the remineralization.

Key-words:
Dental caries
Initial caries lesions
Remineralization
Fluride
Casin
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Bibliografia
[1-]
G.J. Mount.
Defining, classifying, and placing incipient caries lesions in perspective.
Dent Clin N Am, 49 (2005), pp. 701-723
[2-]
Melo P R. Influência de diferentes métodos de administração de fluoretos nas variações de incidência de cárie. Tese de Doutoramento. Faculdade de Medicina Dentária da Universidade do Porto 2001.
[3-]
C.A.M. Kinch, M.E. McLean.
Dentisteria minimamente invasiva.
Am J Dent ed. Portuguesa, 4 (2004), pp. 7-16
[4-]
W.H. Arnold, A. Haase, J. Hacklaender, Z. Gintner, J. Bánóczy, P. Gaengler.
Effect of pH of amine fluoride containing toothpastes on enamel remineralization in vitro.
BMC Oral Healt, 17 (2007), pp. 7-14
[5-]
C.M. Barnes.
Dental hygiene participation in managing incipient and hidden caries.
Dent Clin N Am, 49 (2005), pp. 795-813
[6-]
V.P. Thompson, J.M. Kaim.
Nonsurgical treatment of incipient and hidden caries.
Dent Clin N Am, 49 (2005), pp. 905-921
[7-]
A.M. Acevedo, C. Machado, L.E. Rivera, M. Wolff, I. Kleinberg.
The inhibitory effect of an arginine bicarbonate/calcium carbonate (CaviStat®)-containing dentifrice on the development of dental caries in Venezuelan school children.
J Clin Dent, 16 (2005), pp. 63-70
[8-]
A. Pereira, et al.
Cáries Precoces de Infância, Edições Medisa, (1997),
[9-]
M. Hennequin.
Dynamique du processus carieux initial.
Real Clin, 10 (1999), pp. 483-501
[10-]
D. Mccomb.
Conservative operative management strategies.
Dent Clin N Am, 49 (2005), pp. 847-865
[11-]
H.E. Strassler, J. Porter, C.L. Serio.
Contemporary treatment of incipient caries and rationale for conservative operative techniques.
Dent Clin N Am, 49 (2005), pp. 867-887
[12-]
J.M. Ten Cate.
Fluorides in caries prevention and control: empiricism or science.
Caries Res, 38 (2004), pp. 254-257
[13-]
E. Reich, L.G. Petersson, L. Netuschi, M. Brecx.
Mouthrinses and dental caries.
Int Dent J, 52 (2002), pp. 337-345
[14-]
J.D.B. Featherstone.
Prevention and reversal of dental caries: role of low level flouride.
Community Dent Oral Epidemiol, 27 (1999), pp. 31-40
[15-]
A.F.P. Leme, C.P.M. Tabchoury, D.T. Zero, J.A. Cury.
Effect of fluoridated dentifrice and acidulated phosphate fluoride application on early artificial carious lesions.
Am J Dent, 16 (2003), pp. 91-95
[16-]
L. Baratieri, et al.
Odontologia Restauradora. Fundamentos e Possibilidades.
Santos Livraria Editora, (2001),
[17-]
Domingues J F. Estudo epidemiológico da influência de flúor na prevalência de cárie dentária em adolescentes. Tese de Mestrado. Faculdade de Medicina Dentária da Universidade do Porto 2006.
[18-]
E. Newbrun.
Topical fluorides in caries prevention and management: a north american perspective.
J Dent Edu, 65 (2001), pp. 1078-1083
[19-]
S. Zimmer.
Caries-preventive effects of fluoride products when used in conjunction with fluoride dentifrice.
Caries Res, 35 (2001), pp. 18-21
[20-]
E. Casals, T. Boukpessi, C.M. McQueen, S.L. Eversole, R.V. Faller.
Anticaries potential of commercial dentifrices as determined by fluoridation and remineralization efficiency.
J Contemp Dent Pract., 8 (2007), pp. 1-10
[21-]
A.B. Ammari, A. Bloch-Zupan, et al.
Systematic review of studies comparing the anti-caries efficacy of children's toothpaste containing 600 ppm of fluoride or less with high fluoride toothpastes of 1,000 ppm or above.
Caries Res, 37 (2003), pp. 85-92
[22-]
R.J. Lynch, J.M. Ten Cate.
The anti-caries efficacy of calcium carbonate-based fluoride toothpastes.
Int Dent J, 55 (2005), pp. 175-178
[23-]
A. Bloch-Zupan.
Is the fluoride concentration limit of 1,500 ppm in cosmetics (EU guideline) still up-to-date?.
Caries Res, 35 (2001), pp. 22-25
[24-]
P. Thaveesangpanich, A. Itthagarun, et al.
The effects of child formula toothpastes on enamel caries using two in vitro pH-cycling models.
Int Dent J, 55 (2005), pp. 217-223
[25-]
U.M. Sköld, D. Birkhed, E. Borg, L.G. Petersson.
Approximal caries development in adolescents with low to moderate caries risk after different 3-year school-based supervised fluoride mouth rinsing programmes.
Caries Res, 39 (2005), pp. 529-535
[26-]
S. Twetman, L. Petersson, S. Axelsson, H. Dahlgren, A.K. Holm, C. Kallestal.
Caries-preventive effect of sodium fluoride mouthrinses: a systematic review of controlled clinical trials.
Acta Odontol Scand, 62 (2004), pp. 223-230
[27-]
A. Pereira.
Cárie Dentárias. Etiologia, Epidemiologia e Prevenção.
Ed. Medisa, (1993),
[28-]
D.W. Johnston.
Current status of professionally applied topical fluorides.
Community Dent Oral Epidemiol, 22 (1994), pp. 159-163
[29-]
WHO. Fluorides and oral health: Expert Committee on Oral Health Status and Fluoride Use, 1994.
[30-]
U.M. Sköld, D. Birkhed, A. Lith, L.G. Petersson.
Effect of Scholl-based fluoride varnish programmes on approximal caries in adolescents from different caries risk areas.
Caries Res, 39 (2005), pp. 273-279
[31-]
T. Attin, A.M. Lennon, M. Yakin, K. Becker, W. Buchalla, R. Attin, A. Wiegand.
Deposition of fluoride on enamel surfaces released from varnishes is limited to vicinity of fluoridation site.
Clin Oral Inv, 11 (2007), pp. 83-88
[32-]
J.P. Pessan, M.L.G. Pin, C.C.R. Martinhon, S.M.B. Silva, J.M. Granjeiro, M.A.R. Buzalaf.
Analyses of fingernails and urine as biomarkers of fluoride exposure from dentifrice and varnish in 4 to 7-year-old children.
Caries Res, 39 (2005), pp. 363-370
[33-]
J.M. Ten Cate.
Current concepts on the theories of the mechanism of action of fluoride.
Acta Odontol Scand, 57 (1999), pp. 325-329
[34-]
S.A. Leach, G.T. Lee, W.M. Edgar.
Remineralization of artificial caries-like lesions in human enamel in situ by chewing sorbitol gum.
J Dent Res, 68 (1989), pp. 1064-1068
[35-]
N.V. Castioni, P.C. Baehni, R. Gurny.
Current status in oral fluoride pharmacokinetics and implications for the prophylaxis against dental caries.
Eur J Pharm Biopharm, 45 (1998), pp. 101-111
[36-]
K.J. Toumba, M.E. Curzon.
A clinical trial of a slow-releasing fluoride device in children.
Caries Res, 39 (2005), pp. 195-200
[37-]
E. Brambilla.
Fluoride - is it capable of fighting old and new dental diseases?. An overview of existing fluoride compounds and their clinical applications.
Caries Res, 35 (2001), pp. 6-9
[38-]
K.J. Cross, N.L. Huq, E.C. Reynolds.
Casein phosphopeptides in oral health-chemistry and clinical applications.
Curr Pharm Des, 13 (2007), pp. 793-800
[39-]
M. Oshiro, K. Yamaguchi, T. Takamizawa, H. Inage, T. Watanabe, A. Irokawa, S. Ando, M. Miyazaki.
Effect of CPP-ACP paste on tooth mineralization: an FE-SEM study.
J Oral Sci, 49 (2007), pp. 115-120
[40-]
E.C. Reynolds, et al.
Os progressos na remineralização do esmalte: fosfopeptídeos de caseína-fosfato de cálcio amorfo.
J Clin Dent, 10 (1999), pp. 86-88
[41-]
E.C. Reynolds, F. Cai, P. Shen, G.D. Walker.
Retention in plaque and remineralization of enamel lesions by various froms of calcium in a mouthrinse or sugar-free chewing gum.
J Des Res, 82 (2003), pp. 206-211

(Costa E, Domingues J, Ferreira JC, Melo P. Tratamento Medicamentoso de Lesões Iniciais de Cárie. Agentes terapêuticos remineralizantes. Rev Port Estomatol Cir Maxilofac 2009;50:43–51)

Copyright © 2009. Sociedade Portuguesa de Estomatologia e Medicina Dentária
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