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Vol. 38. Issue 4.
Pages 224-228 (July - August 2019)
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Vol. 38. Issue 4.
Pages 224-228 (July - August 2019)
Original Article
DOI: 10.1016/j.remnie.2019.02.004
18F-FDG PET/CT brown fat detection: Differences between adult and pediatric population in a 12 year experience
Detección de grasa parda en la PET/TC con 18F-FDG: diferencias entre la población adulta y pediátrica en una experiencia de 12 años
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Mattia Bonacinaa,
Corresponding author
mattia.bonacina@gmail.com

Corresponding author.
, Domenico Albanoa, Maria Gazzillia, Rexhep Durmoa, Elisabetta Cerudellia, Giovanni Bosioa, Francesco Bertagnab, Raffaele Giubbinib
a Nuclear Medicine, Spedali Civili Brescia, Brescia, Italy
b Nuclear Medicine, University of Brescia and Spedali Civili Brescia, Brescia, Italy
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Tables (3)
Table 1. Total population studied with 18F-FDG PET/CT from 2005 to 2017, showing the different distribution of age and gender and the proportions with BAT positive PET population.
Table 2. Different distribution of anthropometric and methabolic features in adult and pediatric population showing brown fat detection in 18F-FDG PET/CT scans.
Table 3. Table showing exam's season and season of birth role in predicting brown fat detection in 18F-FDG PET/CT scans.
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Abstract
Purpose

To analyze epidemiological and anthropometric features of patients with brown adipose tissue (BAT) activation detected by fluorine18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT).

Materials and methods

From 2005 to 2017, 818 18F-FDG PET/CT studies positive for BAT detection were retrospectively included, 742 examinations performed on the adult population and 76 PET/CT on the pediatric population. A Chi-squared test was performed to compare features distribution between the adult and pediatric patients.

Results

Adults showed a higher rate of BAT detection in females (79% vs 61%, p<0.001) and in hyperglycaemic patients (>100mg/dL) (24% vs 16%, p=0.02), no significant difference was found with regard to overweight patients (BMI>25kg/m2) (22% vs 20%, p=0.55). Considering females only, the adults showed a higher rate of BAT detection both in hyperglycaemic (83% vs 42%, p<0.001) and overweight patients (80% vs 67%, p=0.005). In both populations BAT activation happened more frequently in cold seasons; there was no significant distribution difference with regard to season of birth (p=0.2).

Conclusions

Sex, glycemia and BMI play a major role in predicting BAT activation, with significant differences between adults and pediatric patients. Cold exposure is confirmed as an important predicting factor, while season of birth is not significant.

Keywords:
Brown adipose tissue
18F-FDG
PET/CT
Resumen
Objetivo

Analizar las características epidemiológicas y antropométricas de los pacientes con activación de la grasa parda detectada por tomografía por emisión de positrones con fluoruro 18-fluorodeoxiglucosa/tomografía computarizada (18F-FDG PET/TC).

Material y métodos

De 2005 a 2017, se incluyeron retrospectivamente 818 estudios PET/TC con 18F-FDG positivos para detección de grasa parda 742 exámenes realizados en población adulta y 76 PET/TC en población pediátrica. Se realizó una prueba de Chi cuadrado para comparar la distribución de las características entre pacientes adultos y pediátricos.

Resultados

Los adultos mostraron una tasa más alta de detección de grasa parda en mujeres (79% vs 61%, p<0,001) y en pacientes con hiperglicemia (>100mg/dL) (24% vs 16%, p=0,02), no se encontraron diferencias significativas considerando el sobrepeso (IMC>25kg/m2) (22% vs 20%, p=0,55). Teniendo en cuenta solo a mujeres, los adultos mostraron una tasa más alta de detección de grasa parda tanto en pacientes con hiperglicemia (83% frente a 42%, p<0,001) como en pacientes con sobrepeso (80% frente a 67%, p=0,005). En ambas poblaciones, la activación de la grasa parda ocurrió con mayor frecuencia en las estaciones frías; noón considerando la temporada de nacimiento (p=0,2).

Conclusiones

El sexo, la glucemia y el IMC desempeñan un papel importante en la predicción de la activación de la grasa parda, con diferencias significativas entre adultos y niños. Se confirma que la exposición al frío es un factor de predicción importante, mientras que la temporada de nacimiento no es significativa.

Palabras clave:
Tejido adiposo pardo
18F-FDG
PET/TC

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