Buscar en
Radiología (English Edition)
Toda la web
Inicio Radiología (English Edition) Preoperative lymphoscintigraphy and tumor histologic grade are associated with s...
Journal Information
Vol. 56. Issue 6.
Pages 515-523 (November - December 2014)
Share
Share
Download PDF
More article options
ePub
Visits
858
Vol. 56. Issue 6.
Pages 515-523 (November - December 2014)
Original article
DOI: 10.1016/j.rxeng.2012.11.004
Preoperative lymphoscintigraphy and tumor histologic grade are associated with surgical detection of the sentinel lymph node
La linfogammagrafía prequirúrgica y el grado histológico del tumor se asocian a la detección quirúrgica del ganglio centinela
Visits
...
M. Arias Ortegaa,
Corresponding author
mariaariasortega@hotmail.com

Corresponding author.
, M.Y. Torres Sousab, B. González Garcíac, R. Pardo Garcíad, A. González Lópeze, M. Delgado Portelaf
a Servicio de Radiodiagnóstico, Hospital La Mancha-Centro, Alcázar de San Juan, Ciudad Real, Spain
b Servicio de Radiodiagnóstico, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain
c Servicio de Medicina Nuclear, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain
d Servicio de Cirugía General, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain
e Servicio de Obstetricia y Ginecología, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain
f Servicio de Anatomía Patológica, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (2)
Tables (3)
Table 1. Inclusion and exclusion criteria of patients until 2007 according to recommendations from the expert meeting held in Salamanca in 2001.
Table 2. Starting 2007 the following recommendations were added following the expert meeting held in Murcia in 2006.
Table 3. Descriptive analysis.
Show moreShow less
Abstract
Objective

To study which variables involved in the process of selective sentinel node biopsy (SSNB) influence the intraoperative detection of the sentinel lymph node.

Material and methods

This was a prospective cross-sectional study in 210 patients (mean age, 54 years) diagnosed with breast cancer who underwent SSNB. We recorded clinical, radiological, radioisotope administration, surgical, and histological data as well as follow-up data. We did a descriptive analysis of the data and an associative analysis using multivariable regression.

Results

Deep injection alone was the most common route of radioisotope administration (72.7%). Most lesions were palpable (57.1%), presented as nodules (67.1%), measured less than 2cm in diameter (64.8%), were located in the upper outer quadrant (49.1%), were ductal carcinomas (85.7%), were accompanied by infiltration (66.2%), and had a histologic grade of differentiation of II (44.8%). Preoperative scintigraphy detected the sentinel node in 97.6% of cases and 95.7% were detected during the operation. One axillary relapse was observed. In the associative study, the variables “preoperative lymphoscintigraphy” and “histologic grade of differentiation of the tumor” were significantly associated with the detection of the sentinel lymph node during the operation.

Conclusion

The probability of not detecting the sentinel lymph node during the surgical intervention is higher in patients with high histologic grade tumors or in patients in whom preoperative lymphoscintigraphy failed to detect the sentinel node.

Keywords:
Sentinel node biopsy
Breast cancer
Surgery
Nuclear imaging
Resumen
Objetivo

Estudiar qué variables implicadas en el proceso de la biopsia selectiva del ganglio centinela (BSGC) influyen en la detección intraoperatoria del ganglio centinela.

Material y métodos

Estudio transversal prospectivo de 210 pacientes (edad media: 54 años) diagnosticadas de cáncer de mama a las que se les realizó BSGC. Se recogieron los datos clínicos y radiológicos, de la administración del radioisótopo, quirúrgicos, de anatomía patológica y de seguimiento, y se realizó un análisis descriptivo y asociativo mediante una regresión múltiple multivariante.

Resultados

La vía de inyección del radioisótopo más utilizada fue la profunda aislada (72,7%). La mayoría de las lesiones fueron palpables (57,1%), se presentaron como nódulos (67,1%), fueron menores de 2cm (64,8%), se localizaron en el cuadrante supero-externo (49,1%), se trataba de carcinomas ductales (85,7%), con infiltración (66,2%) y el grado de diferenciación histológica fue II (44,8%). Con la gammagrafía prequirúrgica se detectó el ganglio centinela en el 97,6% de los casos, y en el quirófano el 95,7%. Se observó una recurrencia axilar. En el estudio asociativo, las variables «linfogammagrafía prequirúrgica» y «grado de diferenciación histológica del tumor» mostraron una asociación estadísticamente significativa con la detección del ganglio centinela en el quirófano.

Conclusión

La probabilidad de no detectar el ganglio centinela durante la intervención quirúrgica es mayor en los pacientes con tumores de alto grado histológico o en las que no se ha conseguido verlo en la linfogammagrafía prequirúrgica.

Palabras clave:
Biopsia del ganglio centinela
Cáncer de mama
Cirugía
Imagen nuclear

Article

These are the options to access the full texts of the publication Radiología (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos