Buscar en
Porto Biomedical Journal
Toda la web
Inicio Porto Biomedical Journal Neuroimaging analysis of rare brain metastases from prostate cancer
Journal Information
Vol. 2. Issue 5.
Pages 220 (September - October 2017)
Share
Share
Download PDF
More article options
Vol. 2. Issue 5.
Pages 220 (September - October 2017)
PS171
Open Access
Neuroimaging analysis of rare brain metastases from prostate cancer
Visits
3423
Juliana Macedo1,
Corresponding author
ju.p.macedo18@gmail.com

Corresponding author.
, Eduarda Carneiro4, Diana Ferreira4, António Verdelho5, Luís Pedro Afonso6, Joaquina Maurício7, Susana Maria Silva2,3, Mavilde Arantes2,3,4
1 Faculty of Medicine of the University of Porto, 4200-319 Porto, Portugal
2 Unit of Anatomy, Department of Biomedicine, Faculty of Medicine of the University of Porto, 4200-319 Porto, Portugal
3 Center for Health Technology and Services Research (CINTESIS), 4200-450, Portugal
4 Division of Neuroradiology, Radiology Service, Portuguese Institute of Oncology, Porto, Portugal
5 Neurosurgery Service, Portuguese Institute of Oncology, Porto, Portugal
6 Pathological Anatomy Service, Portuguese Institute of Oncology, Porto, Portugal
7 Medical Oncology Service, Portuguese Institute of Oncology, Porto, Portugal
This item has received

Under a Creative Commons license
Article information
Full Text
Bibliography
Download PDF
Statistics
Full Text

Aim: Our main study focus was to evaluate the incidence, imaging characteristics, and prognosis of parenchymal brain metastases originating from prostatic tumors.

Introduction: Prostate cancer is considered the second most commonly diagnosed cancer.1 In addition, it is considered the fifth leading cause of cancer death amongst males.2 A small percentage (2%) of patients with prostate cancer are found to be castrate-resistant and to develop brain metastasis, a rare complication which is associated to an advanced systemic state of the disease when the tumor has already spread to other sites.3 Although, there is not much evidence on optimal management of these patients.4

Methods: A review of case records of prostate cancer patients within the IPO Porto data base from 2013 to 2015 was conducted in order to identify the patients with prostate cancer and evidence of brain metastases. As criteria of exclusion, cases transferred to other hospitals without follow up and cases that were incorrectly categorized were excluded.

Results: We screened 2194 patients with prostate cancer, with only one having evidence of brain metastasis. Additionally, one case was identified with bilateral orbital metastatic lesions. The patient with evidence of brain metastasis aged 48 years old. Magnetic resonance imaging showed six metastatic lesions, three infratentorial and three supratentorial. The largest lesion was found in the parieto-occipital region. These brain metastasis were detected 42 months after the initial diagnosis of prostate adenocarcinoma. In addition, by the time of brain metastasis detection, the patient already had bone metastatic lesion.

Conclusion: Brain metastases from prostate cancer are rare, with only a few cases described in the literature. Variable magnetic resonance imaging characteristics are described. Brain metastases are also associated with a poor prognosis, with a mean survival of 1–7.6 months.

References
[1]
T. Barakat, A. Agarwal, R. McDonald, V. Ganesh, S. Vuong, M. Borean, et al.
Solitary brain metastasis from prostate cancer: a case report.
Ann Palliat Med, 5 (2016), pp. 227-232
[2]
J. Craig, J. Woulfe, J. Sinclair, S. Malone.
Isolated brain metastases as first site of recurrence in prostate cancer: case report and review of the literature.
Curr Oncol, 22 (2015), pp. e493-e497
[3]
G. Taddei, S. Marzi, G. Coletti, D. De Paulis, A. Ricci, R.J. Galzio.
Brain metastasis from prostate adenocarcinoma: case report and review of literature.
World J Oncol, 3 (2012), pp. 83-86
[4]
A. Gizewska, E. Witkowska-Patena, Z. Stembrowicz-Nowakoska, A. Buraczewska, M. Dziuk.
Brain metastases in patient with prostate cancer found in 18F-choline PET/CT.
Nuclear Med Rev, 18 (2015), pp. 39-41
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos