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Vol. 26. Issue 6.
Pages 319-324 (January 2011)
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Vol. 26. Issue 6.
Pages 319-324 (January 2011)
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Relationship between the type and side of motor symptoms with the prevalence of non-motor symptoms in Parkinson's disease
Relación entre el tipo y lado de inicio de la sintomatología motora con la frecuencia de síntomas no motores en la enfermedad de Parkinson
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M. Rodríguez-Violantea,b,
Corresponding author
mrodriguez@innn.edu.mx

Corresponding author.
, A. Cervantes-Arriagaa,c, A. Villar-Velardea, T. Coronaa
a Laboratorio Clínico de Enfermedades Neurodegenerativas, Mexico
b Clínica de Movimientos Anormales, Mexico
c Medicina Interna, Instituto Nacional de Neurología y Neurocirugía, Mexico
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Article information
Abstract
Introduction

The relationship between laterality and asymmetry of Parkinson's disease and non-motor dysfunction has been studied mainly from the perspective of cognitive functions, and the few studies that have included other symptoms have mixed reports. The relationship between non-motor symptoms and the type of onset of the disease has not been studied in detail.

Objective

To analyse the association between the side and type of motor onset and the prevalence of non-motor symptoms.

Patients and methods

We included 232 patients diagnosed with Parkinson's disease. Type of onset and the side initially affected were documented. The presence of non-motor symptoms was determined by applying the non-motor symptom questionnaire (NMSQuest).

Results

When analysing the side of onset and presence of each non-motor symptom explored, statistically significant differences were found in the frequency of hallucinations (P=.04) and sleep behaviour disorder (P<.01) in subjects with right side onset. The motor type of onset differences were not statistically significant.

Conclusions

Subjects with right side onset seem to have a higher risk of having hallucinations and sleep behaviour disorders. These symptoms should be intentionally sought in order to provide treatment and improve the patient's quality of life.

Keywords:
Laterality
Non-motor dysfunction
Parkinson's disease
Psychosis
Rigidity
Tremor
Resumen
Introducción

La relación de la lateralidad y asimetría de la enfermedad de Parkinson con la sintomatología de disfunción no motora ha sido abordada principalmente desde el punto de vista de las funciones cognitivas, y los escasos estudios que han involucrado otros síntomas han sido contradictorios. La asociación de los síntomas no motores con el tipo de inicio de la enfermedad no ha sido estudiada profundamente.

Objetivo

Analizar la asociación entre el lado de inicio de la sintomatología motora, así como del tipo de inicio termorígeno y rígido-bradicinético y la prevalencia de síntomas no motores.

Pacientes y métodos

Se incluyeron 232 pacientes con diagnóstico de enfermedad de Parkinson. Se documentó el tipo de inicio y el hemicuerpo afectado inicialmente. La presencia de síntomas no motores se determinó mediante la aplicación del cuestionario de síntomas no motores (NMSQuest).

Resultados

Al analizar el lado de inicio y la presencia de los síntomas no motores explorados se encontraron diferencias estadísticamente significativas en la frecuencia de alucinaciones (p=0,04) y del trastorno conductual del sueño (p<0,01) en los sujetos de inicio del lado derecho. En el caso del tipo de inicio no se encontraron diferencias con significación estadística.

Conclusiones

Los sujetos con inicio en el hemicuerpo derecho parecen tener un mayor riesgo de presentar tanto alucinaciones como trastorno conductual del sueño. El médico tratante debe buscar de forma intencionada estos síntomas en estos pacientes, y de esta manera otorgar un tratamiento adecuado que impacte en la calidad de vida de los mismos.

Palabras clave:
Disfunción no motora
Enfermedad de Parkinson
Lateralidad
Psicosis
Rigidez
Temblor
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Copyright © 2011. Sociedad Española de Neurología
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