Buscar en
Neurología (English Edition)
Toda la web
Inicio Neurología (English Edition) Paralysis of VI cranial pair after epidural anaesthesia. Reply
Journal Information
Vol. 27. Issue 9.
Pages 585-586 (November - December 2012)
Vol. 27. Issue 9.
Pages 585-586 (November - December 2012)
Letter to the Editor
Full text access
Paralysis of VI cranial pair after epidural anaesthesia. Reply
Paresia del VI par tras anestesia epidural. Réplica
A. Labiano-Fontcubertaa,b, J. Benito-Leóna,b,c,d,��
Corresponding author

Corresponding author.
a Servicio de Neurología, Hospital Universitario 12 de Octubre, Madrid, Spain
b Departamento de Medicina, Facultad de Medicina, Universidad Complutense, Madrid, Spain
c Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Madrid, Spain
Article information
Full Text
Download PDF
Full Text
Dear Editor:

It was with great interest that we read the study recently published by Durán-Ferreras1 describing VI cranial nerve dysfunction secondary to intracranial hypotension (IH) syndrome. While the author clearly explains the physiopathological mechanism underlying VI cranial nerve dysfunction and other clinical manifestations typical of intracranial hypotension syndrome, he barely mentions the syndrome's characteristic radiological signs even though the clinical-radiological correlation is evident.2

Intracranial hypotension syndrome is a clinical-radiological entity resulting from cerebrospinal fluid volume depletion secondary to dural laceration.3 It is easy to assign a suspected diagnosis in the presence of clear clinical symptoms (especially orthostatic headache) and an obvious cause. However, cases exist in which doctors cannot identify the precipitating factor (idiopathic or essential intracranial hypotension syndrome).3

The case in question illustrates one of the radiological signs associated with intracranial hypotension: the presence of subdural collections.2 Nevertheless, we should note that the key radiological finding in intracranial hypotension syndrome is diffuse dural thickening with enhanced gadolinium uptake.3 This may be the earliest sign of onset, and its persistence is directly related to headache duration.4–6 Other radiological signs associated with intracranial hypotension syndrome and already mentioned by the author1 are rostrocaudal gradient and decreased size of subarachnoid cisterns.2

However, the author does not mention pituitary enlargement, which is another radiological finding consistently associated with intracranial hypotension syndrome.7–9 This less familiar radiological finding appears alongside dural thickening, and both processes share a common pathogenic mechanism.8 Our group analysed pituitary enlargement in 11 consecutive patients with intracranial hypotension syndrome. We observed pituitary enlargement in all patients; following clinical improvement, the pituitary returned to its normal size.8 We should highlight that pituitary reverted to its normal size before dural thickening had resolved.8 The physiopathological cause underlying both radiological signs is alteration of cerebrospinal fluid secondary to intracranial hypotension. According to the Monro-Kellie doctrine, cerebrospinal fluid hypovolaemia would result in a compensatory increase in blood volume, that of venous blood. Vasodilation in epidural venous sinuses increases pressure in the cavernous sinus and, in turn, the size of the pituitary. The same venous hyperaemia also causes diffuse dural thickening with gadolinium-contrast enhancement. Lastly, it is important to distinguish this sign from other pituitary anomalies such as adenomas or even physiological changes (such as pituitary enlargement occurring during puberty).7–9

E. Durán-Ferreras.
Paresia del VI par tras anestesia epidural.
Neurologia, 26 (2011), pp. 252-254
M.A. Reina, J. Alvarez-Linera, A. López, J. Benito-León, J.A. De Andrés, R.G. Sola.
Aportaciones de la resonancia magnética en la cefalea pospunción dural y en pacientes que cursan con hipotensión de líquido cefaloraquídeo.
Revista Espanola de Anestesiologia y Reanimacion, 49 (2002), pp. 89-100
J. Benito-León, M.A. Reina, J. Álvarez-Linera.
El síndrome de hipotensión intracraneal.
Neurologia, 16 (2001), pp. 418-426
A.S. Pakiam, C. Lee, A.E. Lang.
Intracraneal hypotension with parkinsonism, ataxia and bulbar weakness.
Archives of Neurology, 56 (1999), pp. 869-872
B. Mokri, S.F. Hunter, J.L.D. Atkinson, D.J. Piepgras.
Orthostatic headache caused by CSF leak but with normal CSF pressure.
Neurology, 51 (1998), pp. 786-790
M. Benamor, C. Tainturier, P. Graveleau, L. Pierot.
Radionuclide cisternography in spontaneus intracraneal hypotension.
Clinical Nuclear Medicine, 23 (1998), pp. 150-151
N. Shimazu, H. Oba, S. Aoki, S. Monzawa, K. Makita, T. Araki.
Pituitary enlargement in spontaneus intracraneal hypotension on MRI.
Nippon Igaku Hoshasen Gakkai Zasshi – Nippon Acta Radiologica, 58 (1998), pp. 349-352
J. Alvarez-Linera, J. Escribano, J. Benito-León, J. Porta-Etessam, A. Rovira.
Pituitary enlargement in patients with intracranial hypotension syndrome.
Neurology, 55 (2000), pp. 1895-1897
B. Mokri, J.L.D. Atkinson.
False pituitary tumor in CSF leaks.
Neurology, 55 (2000), pp. 573-575

Dr. Benito-León is funded by the National Institutes of Health, Bethesda, MD, USA (NIH R01 NS039422).

Please cite this article as: Labiano-Fontcuberta A, Benito-León J. Paresia del VI par tras anestesia epidural. Réplica. Neurología. 2012;27:285–6.

Copyright © 2011. Sociedad Española de Neurología
Article options
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos