Buscar en
Neurología (English Edition)
Toda la web
Inicio Neurología (English Edition) Charles Bonnet syndrome secondary to hypertensive crisis
Journal Information
Vol. 33. Issue 7.
Pages 473-474 (September 2018)
Vol. 33. Issue 7.
Pages 473-474 (September 2018)
Letter to the Editor
DOI: 10.1016/j.nrleng.2018.04.001
Open Access
Charles Bonnet syndrome secondary to hypertensive crisis
Síndrome de Charles Bonnet secundario a crisis hipertensiva
Visits
...
P. Cifuentes-Canorea
Corresponding author
pilarcifuca@gmail.com

Corresponding author.
, I. Cerván-López, I. Rodríguez-Uña, E. Santos-Bueso
Servicio de Oftalmología, Unidad de Neurooftalmología, Instituto de Investigación Sanitaria, Hospital Clínico San Carlos (IdISSC), Madrid, Spain
Article information
Full Text
Bibliography
Download PDF
Statistics
Figures (1)
Full Text
Dear Editor:

The increase in such age-related diseases as age-related macular degeneration (ARMD) is causing higher incidence of Charles Bonnet syndrome (CBS), which consists of visual hallucinations in patients with preserved cognitive status.1 CBS has been associated with systemic diseases2–4 and topical5 and systemic6,7 treatments. We present a case of CBS triggered by a hypertensive crisis, which was self-limiting with monitoring of arterial pressure at the emergency department.

Our patient is an 85-year-old man who attended a private consultation due to a first known episode of hypertensive crisis accompanied by visual alterations. His personal history included atrophic ARMD in both eyes (OU), diagnosed 5 years previously; arterial hypertension (AHT), which had been treated with losartan (50mg daily) for 10 years, although treatment was not strictly followed; and type 2 diabetes mellitus treated with diet for 3 years. During the examination, the patient presented arterial pressure (AP) values of 210/190mmHg, then reported seeing several unknown people who did not speak. Hallucinations featured colour and movement. Although the patient knew they were not real, he was alarmed by the fact that he could see them clearly despite his poor vision. He also presented holocranial headache, a sensation of palpitations, and epistaxis as the only accompanying symptoms. No seizures or any other neurological manifestations were observed during the episode. A computed tomography (CT) scan revealed no other alterations. The patient was given 2 oral doses of 50mg captocapril separated by 30min to control AP. With the progressive control of AP, the visual hallucinations started to progressively decrease also in number and frequency, disappearing completely 4hours after symptom onset; AP was 160/80mmHg at that time (Fig. 1).

Figure 1.

Chronology of the hypertensive crisis and hallucinations. AP: arterial pressure.

(0.07MB).

He was transferred to our hospital's neuro-ophthalmology department; during the ophthalmological examination, he was able to count fingers at 1metre with OU. Intraocular pressure was 16mmHg in OU. Biomicroscopy yielded normal results and eye fundus examination revealed atrophic ARMD. As other causes of hallucinations were ruled out, the patient was diagnosed with CBS secondary to hypertensive crisis.

The origin of the hallucinations in CBS is unknown, although deafferentiation is thought to be a possible trigger factor for these hallucinations.8–10 According to this theory, since the occipital cortical area receives fewer afferences from the pathological retina, or due to different eye diseases, this compensatory phenomenon would occur in those deafferentiated areas, which would become hyperexcitable before any stimulus.8–10

Development of hallucinations has been associated with such trigger factors as flash blindness or dim lighting,7 systemic7 and surgical11 eye treatments,5,6 and such systemic diseases as anaemia,2 occipital infarcts,3 or multiple sclerosis.4

In our case, the hypertensive crisis would cause a series of reversible functional changes to the deafferentiated cortical areas, which would trigger visual hallucinations. Sustained high AP would cause haemodynamic, chemical, and histological alterations, which would act as trigger factors for visual hallucinations in the occipital cortex. The mechanism would be alteration of the cortical tissue due to high AP in the blood vessel maintaining haemodynamics in these areas. Deafferentiated neurons would be stimulable in this case by hypertension in the cerebral blood vessels corresponding to these cortical areas; with administration of a hypotensive treatment and monitoring of the hypertensive crisis, stimuli and trigger factors disappeared, the episode resolved, and the deafferentiated cortex stabilised.

References
[1]
E. Santos-Bueso, F. Sáenz-Francés, M. Serrador-García, J. Porta-Etessam, J.M. Martínez-de-la-Casa, J. García-Feijoo, et al.
Prevalence and clinical characteristics of Charles Bonnet syndrome in Madrid, Spain.
Eur J Ophthalmol, 24 (2014), pp. 960-963
[2]
P.F. Kaeser, F.X. Borruat.
Acute reversible Charles Bonnet syndrome precipitated by sudden severe anemia.
Eur J Ophthalmol, 19 (2009), pp. 494-495
[3]
P.T. Ashwin, M.D. Tsaloumas.
Complex visual hallucinations (Charles Bonnet syndrome) in the hemianopic visual field following occipital infarction.
J Neurol Sci, 263 (2007), pp. 184-186
[4]
K. Komeima, T. Kameyama, Y. Miyake.
Charles Bonnet syndrome associated with first attack of multiple sclerosis.
Jpn J Ophthalmol, 49 (2005), pp. 533-534
[5]
E. Santos-Bueso, F. Sáenz-Francés, J. Porta-Etessam, J. García-Sánchez.
Charles Bonnet syndrome triggered by brimonidine in a patient with Leber's hereditary optic neuropathy.
Rev Psiquiatr Salud Ment, 7 (2014), pp. 152-153
[6]
E. Santos-Bueso, M. Serrador-García, F. Sáenz-Francés, J. García-Sánchez.
Charles Bonnet syndrome secondary to panretinal photocoagulation.
Neurologia, 30 (2015), pp. 322-323
[7]
J. Mascaro, F. Formiga, R. Pujol.
Charles Bonnet syndrome exacerbated by tramadol.
Aging Clin Exp Res, 15 (2003), pp. 518-519
[8]
E. Santos-Bueso, M. Serrador-García, F. Sáenz-Francés, C.D. Méndez-Hernández, J.M. Martínez-de-la-Casa, J. García-Feijoo, et al.
Paradoxical cessation in a case of Charles Bonnet syndrome.
Arch Soc Esp Oftalmol, 89 (2014), pp. 418-420
[9]
G.J. Menon, I. Rahman, S.J. Menon, G.N. Dutton.
Complex visual hallucinations in the visually impaired: the Charles Bonnet syndrome.
Surv Ophthalmol, 48 (2003), pp. 58-72
[10]
W. Burke.
The neural basis of Charles Bonnet hallucinations: a hypothesis.
J Neurol Neurosurg Psychiatry, 73 (2002), pp. 535-541
[11]
E.J. Choi, J.K. Lee, J.K. Kang, S.A. Lee.
Complex visual hallucinations after occipital cortical resection in a patient with epilepsy due to cortical dysplasia.
Arch Neurol, 62 (2005), pp. 481-484

Please cite this article as: Cifuentes-Canorea P, Cerván-López I, Rodríguez-Uña I, Santos-Bueso E. Síndrome de Charles Bonnet secundario a crisis hipertensiva. Neurología. 2018;33:473–474.

Copyright © 2016. Sociedad Española de Neurología
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

es en pt
Política de cookies Cookies policy Política de cookies
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.