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Inicio Medicina Clínica (English Edition) Role of vitamin D in risk factors of patients with type 2 diabetes mellitus
Journal Information
Vol. 154. Issue 5.
Pages 151-156 (March 2020)
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Vol. 154. Issue 5.
Pages 151-156 (March 2020)
Original article
Role of vitamin D in risk factors of patients with type 2 diabetes mellitus
Papel de la vitamina D en los factores de riesgo de los pacientes con diabetes mellitus tipo 2
Qingqing Zhanga,
Corresponding author

Corresponding author.
, Yucheng Wub, Yu Lua, Xiaoqiang Feia
a Department of Endocrinology, The Affiliated Taizhou People's Hospital of Nantong University, Taizhou 225300, Jiangsu, China
b Department of Cardiology, The Affiliated Taizhou People's Hospital of Nantong University, Taizhou 225300, Jiangsu, China
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Figures (2)
Tables (2)
Table 1. Clinical and laboratory characteristics in vitamin D sufficiency and vitamin D insufficiency group.
Table 2. Correlation coefficients of Lp-PLA2 with 25-(OH)D levels in vitamin D insufficiency and Vitamin D sufficiency group.
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Additional material (1)
Introduction and objectives

Previous observational studies have suggested that low vitamin D status is associated with high circulating C-reactive protein levels, as well as other plasma inflammatory cytokines. However, there is no study to explore the relationship between vitamin D status and Lp-PLA2, a new biomarker of vascular-specific inflammation. The aim of this study was to examine the association between vitamin D status and circulating Lp-PLA2 levels in subjects with type 2 diabetes mellitus.

Material and methods

This descriptive cross-sectional study enrolled diabetic subjects who underwent physical examination at Taizhou People's Hospital between August 2016 and January 2017. Blood pressure, anthropometry, metabolic profiles, serum 25(OH)D levels and Lp-PLA2 mass levels were measured in all participants.


A total of 196 participants were recruited into this study. The vitamin D insufficiency group had higher serum LP-PLA2 levels than the vitamin D sufficiency group (t=−2.765, p=.005). A significant negative correlation was noted between Lp-PLA2 and 25(OH)D in the vitamin D insufficiency group (r=−0.364, p=0.009). However, no significant relationship between serum Lp-PLA2 concentration and 25(OH)D levels was observed in subjects with vitamin D sufficiency.


From this cohort of patients with type 2 diabetes, regardless of traditional cardiovascular risk factors, we observed a statistically significant inverse relation between Lp-PLA2 and 25(OH)D at levels <30ng/mL.

Vitamin D
Cardiovascular risk
Lipoprotein-associated phospholipase A2
Type 2 diabetes
Introducción y objetivos

Los estudios observacionales previos han sugerido que la situación de los bajos niveles de la vitamina D está asociada a los altos niveles de la proteína C reactiva circulantes, así como a otras citoquinas inflamatorias en plasma. Sin embargo, no existe ningún estudio que explore la relación entre la situación de la vitamina D y la lipoproteína asociada a la fosfolipasa A2 (Lp-PLA2), un nuevo biomarcador de la inflamación específico vascular. El objetivo de este estudio fue examinar la asociación entre la situación de la vitamina D y los niveles circulantes de Lp-PLA2 en sujetos con diabetes mellitus tipo 2.

Material y métodos

Estudio transversal descriptivo que incluyó sujetos diabéticos que fueron sometidos a un examen físico en el Hospital popular de Taizhou entre agosto de 2016 y enero de 2017. Se midieron en todos los participantes la presión arterial, la antropometría, los perfiles metabólicos, el suero de 25 (OH) niveles séricos de vitamina D y los niveles de masa de Lp-PLA2.


Un total de 196 participantes fueron reclutados para este estudio. El grupo de insuficiencia de la vitamina D reflejó unos niveles superiores de Lp-PLA2 que el grupo con suficiencia de vitamina D (T=−2,765; p=0,005). Se observó una correlación negativa significativa entre Lp-PLA2 y 25(OH)D en el grupo con insuficiencia de vitamina D (R=−0,364; p=0,009). Sin embargo, no se observó ninguna relación significativa entre la concentración sérica de Lp-PLA2 y 25(OH)D en sujetos con niveles de suficiencia de vitamina D.


A partir de esta cohorte de pacientes con diabetes tipo 2, independientemente de los factores de riesgo cardiovascular, se observó una relación inversa entre Lp-PLA2, estadísticamente significativa, en los niveles de 25(OH)D<30ng/ml.

Palabras clave:
Vitamina D
Riesgo cardiovascular
Fosfolipasa A2 lipoproteína asociada
Diabetes tipo 2


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