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Vol. 147. Issue 1.
Pages 7-12 (July 2016)
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Vol. 147. Issue 1.
Pages 7-12 (July 2016)
Original article
Role of serum leptin in the severity of coronary artery disease in patients with stable angina
Papel de la leptina sérica en la gravedad de la enfermedad coronaria en pacientes con angina estable
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Miguel Jerez-Valeroa,1, Ana Meliveo-Garcíaa,1, Laura Jordán-Martíneza, Fernando Carrasco-Chinchillaa, Inmaculada Moreno-Santosa, Antonio Ordóñezb, Pedro L. Sánchez-Fernándezc, Rafael Vázquezd, José M. Hernández-Garcíaa, Juan J. Gómez-Doblasa, Luis M. Pérez-Belmontea,
Corresponding author
luismiguelpb1984@gmail.com

Corresponding author.
, Eduardo de Teresa-Galvána, Manuel Jiménez-Navarroa
a Unidad de Gestión Clínica del Corazón, Hospital Clínico Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga (UMA), Red de Investigación Cardiovascular (RIC), Málaga, Spain
b Unidad de Gestión Clínica del Corazón, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS), Universidad de Sevilla (US), Red de Investigación Cardiovascular (RIC), Sevilla, Spain
c Servicio de Cardiología, Hospital Universitario de Salamanca, Instituto de Investigación Biomédica de Salamanca (IBISAL), Universidad de Salamanca (USAL), Red de Investigación Cardiovascular (RIC), Salamanca, Spain
d Unidad de Gestión Clínica del Corazón, Hospital Universitario Puerta del Mar, Cádiz, Universidad de Cádiz (UCA), Red de Investigación Cardiovascular (RIC), Cádiz, Spain
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Table 1. Baseline characteristics of the study sample according to coronary disease severity.
Table 2. Association between leptin levels and severity of coronary disease.
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Abstract
Background and objectives

Leptin is a plasmatic peptide hormone that has been related to cardiovascular homeostasis and atherosclerosis but much is still unknown about its relationship with coronary artery disease. The aim of this study was to evaluate the value of serum leptin in patients with stable angina and its relationship with the severity of coronary disease.

Patients and methods

204 patients, 152 with stable angina (coronary artery disease group) and 52 without coronary disease excluded by cardiac computerized tomography (control group) were included. The coronary artery disease group was divided into 2 subgroups according to severity of coronary disease (single or multivessel disease, 46 and 106 patients, respectively). Serum leptin levels were determined by Enzyme-Linked InmunoSorbent Assay.

Results

Leptin levels were significantly higher in patients with multivessel disease and were independently associated with a greater severity of coronary artery disease when compared with controls (OR 1.14; 95%CI: 1.03–1.27; p=0.014) and with patients with single vessel disease (OR 1.12; 95%CI: 1.01–1.25; p=0.036). Serum leptin was tested as a diagnostic marker of multivessel disease with an area under the curve obtained from Receiver Operating Characteristics of 0.6764 (95%CI 0.5765–0.7657).

Conclusions

Serum leptin levels were associated in patients with stable angina with the severity of coronary artery disease, suggesting its value in the development of coronary disease and as a future therapeutic target.

Keywords:
Coronary artery disease
Leptin
Stable angina
Resumen
Fundamentos y objetivo

La leptina es una hormona plasmática que ha sido relacionada con la homeostasis cardiovascular y la aterosclerosis, pero no existen datos concluyentes sobre su asociación con la patogénesis de la enfermedad coronaria. El objetivo de este estudio fue evaluar el valor de la leptina sérica en pacientes con angina estable y su relación con la gravedad de la enfermedad coronaria.

Pacientes y método

Se incluyeron 204 pacientes, 152 con angina estable (grupo con enfermedad coronaria) y 52 sin enfermedad coronaria, excluida por tomografía computarizada cardíaca (grupo control). El grupo con enfermedad coronaria fue dividido en 2 subgrupos atendiendo a la gravedad de la afectación (enfermedad monovaso o multivaso, 46 y 106 pacientes respectivamente). Los niveles de leptina sérica fueron determinados mediante Enzyme-Linked Inmunosorbent Assay.

Resultados

Los niveles de leptina fueron significativamente superiores en los pacientes con enfermedad multivaso y se asociaron de forma independiente con una mayor gravedad de la enfermedad coronaria en comparación con los controles (OR 1,14; IC95% 1,03-1,27; p=0,014) y con pacientes con enfermedad monovaso (OR 1,12; IC95% 1,01-1,25; p=0,036). Se testó el valor diagnóstico de la leptina sérica para el diagnóstico enfermedad multivaso, obteniendo un área bajo la curva en la curva Receiver Operating Characteristic de 0,6764 (IC95% 0,5765-0,7657).

Conclusiones

La leptina sérica se asoció en pacientes con angina estable con la mayor gravedad de la enfermedad coronaria, mostrando su implicación en el desarrollo de la enfermedad coronaria y como futuro objetivo terapéutico.

Palabras clave:
Enfermedad arterial coronaria
Leptina
Angina estable

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