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Vol. 150. Issue 9.
Pages 341-344 (May 2018)
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Vol. 150. Issue 9.
Pages 341-344 (May 2018)
Brief report
DOI: 10.1016/j.medcle.2017.10.036
Relationship between leptin concentrations and disease activity in patients with rheumatoid arthritis
Relación entre las concentraciones de la leptina y la actividad de la enfermedad en pacientes con artritis reumatoide
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José Antonio de Jesús Batún-Garridoa,
Corresponding author
antonio_bg1986@hotmail.com

Corresponding author.
, Marisol Salas-Magañab, Isela Esther Juárez-Rojopb, Eúfrates Hernández-Núñezc, Francisco Olánc
a Unidad de Medicina Interna, Centro Médico ISSET, Tabasco, Mexico
b Unidad de Ciencias Biomédicas, Universidad Juárez Autónoma de Tabasco, Tabasco, Mexico
c Unidad de Medicina Interna, Hospital Dr. Gustavo A. Rovirosa Pérez, Tabasco, Mexico
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Tables (3)
Table 1. General characteristics of the population.
Table 2. Relationship between serum levels of leptin and cardiovascular risk factors in patients with rheumatoid arthritis.
Table 3. Multivariate analysis between significant variables and the presence of hyperleptinemia.
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Abstract
Background and objective

Multiple studies have found a direct relationship between leptin concentrations and disease activity in rheumatoid arthritis.

Patients and methods

We studied 77 patients with the diagnosis of rheumatoid arthritis; the leptin determination was through an enzyme immunoassay. Disease activity was assessed by the DAS-28 CRP. A multivariate logistic regression model was used to determine the association between significant variables and leptin concentrations.

Results

40.3% of the patients were in remission, 41.6% were mildly active, 11.7% were moderately active and 6.5% were severely active. The results show an independent association between higher concentrations of leptin and disease activity (OR 1.7; 95% CI 1.4–3.2; p 0.03), the number of swollen joints (OR 4.6; 95% CI 1.7–8.3; p 0.000), the number of painful joints (OR 3.4; 95% CI 1.6–4.6; p 0.000), and the presence of metabolic syndrome (OR 1.3; 95% IC 1.2–1.9; p 0.045).

Conclusion

The data suggest that serum leptin is elevated in patients with active RA.

Keywords:
Disease activity
Leptin
Rheumatoid arthritis
Resumen
Introducción y objetivo

Múltiples estudios han encontrado una relación directa entre las concentraciones de leptina y la actividad de la enfermedad en artritis reumatoide.

Pacientes y métodos

Se estudiaron 77 pacientes con artritis reumatoide, la determinación de la leptina fue a través de inmunoanálisis enzimático. Se evaluó la actividad de la enfermedad mediante el DAS-28 PCR. Se realizó un modelo de regresión logística multivariante para determinar la asociación entre las variables significativas y las concentraciones de leptina.

Resultados

El 40,3% de los pacientes estaban en remisión, el 41,6% actividad leve, el 11,7% actividad moderada y el 6,5% actividad grave. Se encontró una relación independiente entre mayores concentraciones de leptina y la actividad de la enfermedad (RR 1,7; IC al 95%: 1,4-3,2; p=0,03), el número de articulación tumefactas (RR 4,6; IC al 95%: 1,7-8,3; p=0,000), el número de articulaciones dolorosas (RR 3,4; IC al 95%: 1,6-4,6; p=0,000) y a presencia de síndrome metabólico (RR 1,3; IC al 95%: 1,2-1,9; p=0,045).

Conclusiones

Los datos obtenidos sugieren que la leptina sérica está elevada en pacientes con AR activa.

Palabras clave:
Artritis reumatoide
Leptina
Actividad de la enfermedad

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