Buscar en
Medicina Clínica (English Edition)
Toda la web
Inicio Medicina Clínica (English Edition) Progression over time of changes in anticoagulant treatment in a tertiary hospit...
Journal Information
Vol. 156. Issue 3.
Pages 135-138 (February 2021)
Download PDF
More article options
Vol. 156. Issue 3.
Pages 135-138 (February 2021)
Clinical report
Progression over time of changes in anticoagulant treatment in a tertiary hospital
Evolución temporal de los cambios en el tratamiento anticoagulante en un hospital terciario
Paula Hernández, Lucia Polanco, Ignacio Santiago, Marina Fayos, Carmen Valero
Corresponding author

Corresponding author.
Departamento de Medicina Interna, Hospital Universitario Marqués de Valdecilla, IDIVAL, Universidad de Cantabria, Santander, Spain
This item has received
Article information
Full Text
Download PDF
Figures (2)
Tables (2)
Table 1. Profile of anticoagulated patients in both periods.
Table 2. Characteristics of anticoagulated patients in 2018.
Show moreShow less

The use of direct oral anticoagulants (DOACs) has modified anticoagulant therapy guidelines.


To determine changes and trends in the anticoagulant therapy of inpatients at an Internal medicine department.

Material and methods

1584 inpatients of the internal medicine department (Hospital Marqués de Valdecilla. Santander) were studied in 2008 and 2018. The use of anticoagulant treatment, type of treatment, atrial fibrillation, comorbidity index, thrombotic and haemorrhagic complications were collected from the discharge reports.


The prevalence of anticoagulants increased by 5.7% (13.1% to 18.8%; p=0.002). The mean age increased by 7 years (76.2±11.1 yrs. vs. 83.6±8.9 yrs; p<0.001). The percentage of anticoagulated patients older than 75 yrs doubled. In 2018, 52% of anticoagulated in patients took an DOAC. The prevalence of atrial fibrillation increased by 4% (30% vs. 34%; p=0.04) and by 24% that of anticoagulated atrial fibrillation by 24% (32.3% vs. 56%; p=7.2×10-8). The mean age is 6 years older (78.4±8.2 vs. 84.2±8.0; p<0.001).


The percentage of anticoagulated patients in internal medicine has increased, especially in those with atrial fibrillation.

Atrial fibrillation
Direct oral anticoagulants

Los anticoagulantes orales de acción directa (ACOD) han modificado el tratamiento anticoagulante.


Conocer los cambios y tendencias producidos en la anticoagulación en medicina interna.

Material y métodos

Se estudiaron 1.584 ingresos en medicina interna (Hospital Marqués de Valdecilla. Santander) en 2008 y 2018. Se recogió el tratamiento anticoagulante, indicación y tipo, fibrilación auricular, complicaciones a 6 meses y mortalidad a 2 años.


La prevalencia de anticoagulados aumentó un 5,7% (13,1% vs. 18,8%; p=0,002), la media de edad fue 7 años mayor (76,2±11,1 vs. 83,6±8,9; p<0,001). Se duplicaron los anticoagulados mayores de 75 años. En el 2018 el 52% de los anticoagulados tomaban un ACOD. En 10 años aumentó la prevalencia de fibrilación auricular un 4% (30% vs. 34%; p=0,04) y la de fibrilación auricular anticoagulada un 24% (32,3% vs. 56%; p<0,001). La media de edad fue 6 años mayor (78,4±8,2 vs. 84,2±8,0; p<0,001).


Ha aumentado el porcentaje de pacientes anticoagulados en medicina interna, sobre todo en aquellos con fibrilación auricular.

Palabras clave:
Fibrilación auricular
Anticoagulantes orales de acción directa


These are the options to access the full texts of the publication Medicina Clínica (English Edition)

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe to

Medicina Clínica (English Edition)

Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
Article options
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos