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Inicio Medicina Clínica (English Edition) Modulating the survival and maturation system of B lymphocytes: Current and futu...
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Vol. 145. Issue 5.
Pages 206-210 (September 2015)
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Vol. 145. Issue 5.
Pages 206-210 (September 2015)
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Modulating the survival and maturation system of B lymphocytes: Current and future new therapeutic strategies in systemic lupus erythematosus
Modulación del sistema de supervivencia y maduración del linfocito B: presente y futuro de una nueva estrategia terapéutica en el lupus eritematoso sistémico
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Lara Valor
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lvalor.hgugm@salud.madrid.org

Corresponding author.
, Francisco Javier López-Longo
Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain
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Table 1. Drugs in clinical development having B lymphocyte or its receptors as a direct therapeutic target.
Abstract

Systemic lupus erythematosus is an autoimmune disease associated with an aberrant production of autoantibodies by self-reactive B lymphocytes. The study of the phenotypic characteristics of B lymphocytes and the identification of their surface receptors such as BAFF-R, TACI and BCMA, which are responsible of their survival and maturation, have contributed to the development of new therapeutic strategies in recent years.

Keywords:
Systemic lupus erythematosus
B-cell activation factor
B lymphocyte
Biologic therapies
Resumen

El lupus eritematoso sistémico es una enfermedad autoinmune que está asociada con la producción anormal de autoanticuerpos por parte de linfocitos B autorreactivos. El estudio de las características fenotípicas del linfocito B y la identificación de receptores en su superficie, como BAFF-R, TACI y BCMA, como responsables de su supervivencia y maduración han contribuido en los últimos años al desarrollo de nuevas estrategias terapéuticas.

Palabras clave:
Lupus eritematoso sistémico
B-cell activation factor
Linfocito B
Tratamientos biológicos

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