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Inicio Medicina Clínica (English Edition) Fibrous dysplasia. Clinical review and therapeutic management
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Vol. 147. Issue 12.
Pages 547-553 (December 2016)
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Vol. 147. Issue 12.
Pages 547-553 (December 2016)
Review
Fibrous dysplasia. Clinical review and therapeutic management
Displasia fibrosa. Revisión clínica y abordaje terapéutico
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3
Helena Florez, Pilar Peris
Corresponding author
pperis@clinic.ub.es

Corresponding author.
, Núria Guañabens
Servicio de Reumatología, Hospital Clínic, Universidad de Barcelona, Barcelona, Spain
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Table 1. Treatments and characteristics of previous studies conducted in patients with fibrous dysplasia.
Abstract

Fibrous dysplasia is a skeletal disorder that is associated with a wide spectrum of clinical manifestations, including localized asymptomatic forms and extensive severe forms with severe bone deformities and endocrinological alterations, depending on age, location, extent and associated processes. Although the treatment of choice is based on bisphosphonates, the therapeutic efficacy of these agents in the control of disease activity remains uncertain. This article reviews the current data available on the treatment of this disease as well as the preliminary data on new therapeutic approaches.

Keywords:
Fibrous dysplasia
McCune–Albright syndrome
Bisphosphonates
Denosumab
FGF-23
Resumen

La displasia fibrosa es un trastorno esquelético que dependiendo de la edad, la localización, la extensión y los procesos asociados puede presentarse con un amplio espectro de manifestaciones clínicas, desde formas localizadas asintomáticas a formas extensas graves con deformidades óseas importantes o incluso alteraciones endocrinológicas. Si bien el tratamiento de elección lo constituyen los bisfosfonato, la eficacia en el control de la actividad de la enfermedad continúa siendo incierta. En este artículo se revisan los datos sobre el tratamiento de esta entidad, así como los resultados preliminares de nuevas dianas terapéuticas.

Palabras clave:
Displasia fibrosa
Síndrome de McCune-Albright
Bisfosfonatos
Denosumab
FGF-23

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