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Vol. 157. Issue 11.
Pages 530-534 (December 2021)
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Vol. 157. Issue 11.
Pages 530-534 (December 2021)
Brief report
Effectiveness of the EQ-5D and CRES-4 questionnaire for assessing the impact on the quality of life of patients and the level of satisfaction after exchanging dicumarinics for edoxabán: Real-life experience based on a multicentre study
Utilidad del cuestionario EQ-5D y CRES-4 para la valoración de la calidad de vida y grado de satisfacción tras el cambio de dicumarínicos por edoxabán: experiencia vida real de un estudio multicéntrico
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Francisco J. Guerrero-Márqueza,
Corresponding author
guerreromar24@gmail.com

Corresponding author.
, Ignacio Sainz-Hidalgob, Pablo Cristobo Sainzb, Inmaculada Sigler Vilchesb, Alberto Avilés Toscanoa, Basilio Soto-Espinosa de los Monterosc
a Departamento de Cardiología, Servicio de Medicina Interna, Hospital de la Serranía, Ronda, Málaga, Spain
b Área del Corazón, Servicio de Cardiología, Hospital Virgen del Rocío, Sevilla, Spain
c Unidad de Cuidados Críticos y Medicina Intensiva, Hospital Virgen del Rocío, Sevilla, Spain
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Table 1. Demographic characteristics in relation to the anticoagulation aspects of the patients, and thromboembolic and hemorrhagic events before the switch to edoxaban and during the follow-up of 3 to 6 months.
Abstract
Background and objective

Atrial fibrillation and anticoagulation decrease the quality of life of patients. The aim of this study is to assess the quality of life and the degree of satisfaction after changing from VKA to edoxaban anticoagulants.

Material and methods

Prospective, multicentre study, including 105 patients in dicumarinic anticoagulant treatment replaced by edoxaban. Their quality of life was evaluated before and after using the EQ-5D questionnaire, and the degree of satisfaction with CRES-4 scale.

Results

Average 75 years, CHA2DS2VASC 3.5 and HASBLED 2.1; thromboembolic events and clinically relevant bleeding during follow-up <1%. EQ-5D showed a significant overall improvement in the mobility and anxiety parameters (P = 0.023, 95% CI: 0.0175–0.23; P = 0.019, 95% CI: = 0.028–0.31). The CRES-4 questionnaire showed satisfaction with the therapist of 95%, a positive impact on life of 73% and a negative impact of 3.8%. The emotional state attributed to the change in treatment improved (41% vs 69.5%, P = 0.0001). The final score of the CRES-4 weakly correlated with the emotional situation of the EQ-5D questionnaire.

Conclusions

The change of anticoagulant for edoxaban improves the quality of life and the degree of patient satisfaction, and the EQ-5D and CRES-4 quality of life questionnaires can be used complementarily.

Keywords:
Quality of life
Direct anticoagulants
Therapeutic satisfaction
Resumen
Antecedentes y objetivo

La fibrilación auricular y la anticoagulación merman la calidad de vida de los pacientes. El objetivo del estudio es valorar la calidad de vida y el grado de satisfacción tras el cambio de anticoagulante de AVK a edoxabán.

Material y métodos

Estudio prospectivo, multicéntrico, que incluye a 105 pacientes en tratamiento con dicumarínicos que se sustituye por edoxabán. Se valoró la calidad de vida antes y después a través del cuestionario EQ-5D y el grado de satisfacción con la escala CRES-4.

Resultados

Edad media 75 años, CHA2DS2VASC 3.5 puntos, HASBLED 2.1 puntos; eventos tromboembólicos y hemorragias clínicamente relevantes durante el seguimiento <1%. El EQ5D mostró una mejoría global significativa en los parámetros de movilidad y ansiedad (p = 0.023, IC 95%: 0.0175–0.23; p = 0.019, IC 95%: 0.028–0.31). El CRES-4 recoge una satisfacción con el terapeuta del 95%, una repercusión positiva en la vida del 73% y negativa del 3.8%. La situacional emocional atribuida al cambio de tratamiento mejoró (41% vs 69.5%, p = 0.0001). Se correlacionó débilmente la puntuación final del CRES-4 con la situacional emocional del EQ-5D.

Conclusiones

El cambio de anticoagulante por edoxabán mejora la calidad de vida y el grado de satisfacción del paciente, pudiendo emplearse conjuntamente los cuestionarios de calidad de vida EQ-5D y el CRES-4.

Palabras clave:
Calidad de vida
Anticoagulantes directos
Satisfacción terapéutica

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