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Inicio Medicina Clínica (English Edition) Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: Report of two case...
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Vol. 152. Issue 3.
Pages 104-106 (February 2019)
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Vol. 152. Issue 3.
Pages 104-106 (February 2019)
Clinical report
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: Report of two cases
Hiperplasia neuroendocrina difusa pulmonar idiopática: estudio de dos casos
Eva García-Fontána, Montserrat Blanco Ramosa,
Corresponding author
montseblancoramos@hotmail.com

Corresponding author.
, Jose Soro Garcíaa, Rommel Carrascoa, Miguel Ángel Cañizaresa, Ana González Piñeirob
a Thoracic Surgery Department, Alvaro Cunqueiro University Clinical Hospital, EOXI, Vigo, Spain
b Pathology Department, Alvaro Cunqueiro University Clinical Hospital, EOXI, Vigo, Spain
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Abstract
Introduction

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare disorder characterized by a proliferation of neuroendocrine cells within the lung. It is classically described as a disease with persistent cough, dyspnea and wheezing in non-smoker middle aged females. CT of the chest reveals diffuse air trapping with mosaic pattern.

Patients and methods

We present two cases of DIPNECH that were sent to our department to perform a lung biopsy with the diagnostic suspicion of diffuse interstitial disease. Both cases were women with a history of chronic cough and moderate effort dyspnea.

Results and discussion

The aim of this paper is that physicians take into account this diagnostic entity before treating as an asthmatic a patient with these characteristics, not forgetting that they are prenoplastic lesions.

Keywords:
DIPNECH
Interstitial lung disease
Lung biopsy
Carcinoid tumor
Resumen
Introducción

La hiperplasia neuroendocrina difusa pulmonar idiopática (HNDPI) es una patología poco frecuente que se caracteriza por la proliferación de células neuroendocrinas en el parénquima pulmonar. Se describe clásicamente como una enfermedad que afecta a mujeres de mediana edad no fumadoras y que presentan tos persistente, disnea y sibilancias. La TC muestra una imagen de patrón en mosaico como resultado del atrapamiento aéreo.

Pacientes y métodos

Presentamos dos casos de HNDPI que fueron enviados a nuestro servicio para realizar una biopsia pulmonar con la sospecha diagnóstica de enfermedad intersticial difusa. Ambos casos fueron mujeres con antecedentes de tos crónica y disnea de esfuerzo moderado.

Resultados y discusión

El objetivo de este documento es que los facultativos tengan en cuenta este diagnóstico antes de tratar como asmática a una paciente con estas características, no olvidando además que son lesiones preneoplásicas.

Palabras clave:
Hiperplasia neuroendocrina difusa pulmonar
EPID
Biopsia pulmonar
Tumor carcinoide

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