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Inicio Medicina Clínica (English Edition) Diagnostic value of combined detection of IL-1β, IL-6, and TNF-α for sepsis-in...
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Vol. 158. Issue 9.
Pages 413-417 (May 2022)
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Vol. 158. Issue 9.
Pages 413-417 (May 2022)
Original article
Diagnostic value of combined detection of IL-1β, IL-6, and TNF-α for sepsis-induced cardiomyopathy
Valor diagnóstico de la detección combinada de IL-1, IL-6, y TNF-α para la cardiomiopatía inducida por sepsis
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Peng Deng, Nana Tang, Lin Li, Guohui Zou, Yang Xu, Zhongyong Liu
Corresponding author
lzyongmail@163.com

Corresponding author.
Department of Cardiology, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi Province, China
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Table 1. Comparison of general information [n (%)].
Table 2. Univariate analysis of factors affecting patient deaths [n (%)].
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Abstract
Introduction

This study aimed to explore the diagnostic value and the correlation of the combined detection of interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) with sepsis-induced cardiomyopathy (SIC).

Patients and methods

Admitted to our hospital from January 2017 to January 2019, 96 patients with SIC (a study group) and 90 patients with sepsis (a control group) were enrolled. The three cytokines were determined and the diagnostic value of their combined detection for SIC was analyzed.

Results

The cytokines were remarkably higher in the study group (p<.001). The combined detection of the three had a better diagnostic value for SIC (p<.001). The three cytokines were independent risk factors for the death of patients with SIC.

Conclusion

IL-1β, IL-6, and TNF-α in SIC patients rise markedly. The combined detection of the three has a better predictive value for patients with SIC and is closely related to the patients’ prognoses, so it may be crucial in diagnosing and treating the disease.

Keywords:
IL-1β
IL-6
TNF-α
Sepsis-induced cardiomyopathy
Resumen
Introducción

El objetivo de este estudio fue explorar el valor diagnóstico y la correlación de la detección combinada de interleucina-1β (IL-1β), interleucina-6 (IL-6), y factor de necrosis tumoral-α (TNF-α) con la miocardiopatía inducida por sepsis (CIS).

Pacientes y métodos

Ingresados en nuestro hospital entre enero de 2017 y enero de 2019, se incluyó en el estudio a 96 pacientes con CIS (grupo de estudio) y 90 pacientes con sepsis (grupo control). Se determinaron las tres citocinas y se analizó el valor diagnóstico de su detección combinada para CIS.

Resultados

Las citocinas fueron marcadamente superiores en el grupo de estudio (p<0,001). La detección combinada de las tres tuvo un mejor valor diagnóstico para CIS (p<0,001). Las tres citocinas fueron factores de riesgo independientes de la muerte de los pacientes con CIS.

Conclusión

IL-1β, IL-6, y TNF-α se incrementaron considerablemente en los pacientes de CIS. La detección combinada de los tres valores tiene un mejor valor predictivo para los pacientes con CIS, y está estrechamente relacionada con los pronósticos de los pacientes, lo cual puede ser esencial para diagnosticar y tratar la enfermedad.

Palabras clave:
IL-1β
IL-6
TNF-α
Cardiomiopatía inducida por sepsis

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