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Inicio Medicina Clínica (English Edition) Confidence interval reporting for measures of association in multivariable regre...
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Vol. 153. Issue 6.
Pages 239-242 (September 2019)
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Vol. 153. Issue 6.
Pages 239-242 (September 2019)
Original breve
Confidence interval reporting for measures of association in multivariable regression models in observational studies
Reporte de los intervalos de confianza en medidas de asociación en modelos de regresión multivariable en estudios observacionales
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Adrián González-Marróna, Jordi Realb,c,d, Carles Fornée,f, Albert Roso-Llorachg, Eva María Navarrete-Muñozh,i,j, Jose M. Martínez-Sáncheza,
Corresponding author
jmmartinez@uic.es

Corresponding author.
a Group of Evaluation of Health Determinants and Health Policies, Universitat Internacional de Catalunya, Sant Cugat del Vallès, Spain
b Research support unit Barcelona, Institut Universitari d’Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain
c Epidemiology and Public Health, Universitat Internacional de Catalunya, Sant Cugat del Vallès, Spain
d CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Spain
e Biostatistics Unit, Institut de Recerca Biomèdica de Lleida (IRBLleida), Lleida, Spain
f Department of Basic Medical Sciences, Universitat de Lleida, Lleida, Spain
g University Institute in Primary Care Research Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain
h CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain
i Unit of Nutritional Epidemiology, Department of Public Health, History of Medicine and Gynecology, Universidad Miguel Hernández, Alicante, Spain
j Institute for Health and Biomedical Research (ISABIAL - FISABIO Foundation), Alicante, Spain
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Tables (2)
Table 1. Report of measures of association and confidence intervals (CI) in the abstract and main text of the reviewed articles.
Table 2. Reporting of confidence intervals (CI) before and after the publishing of the STROBE guideline.
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Abstract
Background/Objectives

To assess the adherence to reporting confidence intervals (CI) for measures of association in multivariable regression models (MRM) in articles with observational design indexed in MEDLINE.

Material and methods

A literature search was conducted using the MEDLINE bibliographic database to obtain a representative sample of studies with observational design and applying MRM (logistic, linear, and Cox regression) (n=428). Proportions and 95% CI of articles reporting CI for measures of association in MRM were calculated. Percentage ratios (PRs) were also calculated to describe the change in CI reporting before and after the publication of the STROBE statement.

Results

188 of the 236 abstracts with measures of association (79.7%; 95% CI 74.5, 84.8) and 360 of the 428 main texts (84.1%; 80.6, 87.6) were provided with CI. A non-significant increase of 1% in the abstract, PR=1.01 (0.77, 1.29), and 7% in the main text, PR=1.07 (0.87, 1.28), occurred in the CI reporting after the publication of the STROBE guideline.

Conclusions

The STROBE guideline recommendation on reporting CI should be more thoroughly followed.

Keywords:
Confidence interval
P-value
STROBE guideline
Resumen
Antecedentes/objetivos

Evaluar la adherencia al reporte de los intervalos de confianza (IC) en medidas de asociación en modelos de regresión multivariable (MRM) en artículos con diseño observacional indexados en MEDLINE.

Material y métodos

Se realizó una búsqueda bibliográfica usando la base de datos bibliográfica MEDLINE para obtener una muestra representativa de estudios con diseño observacional y que aplicaran MRM (regresión logística, lineal y Cox) (n=428). Se calcularon las proporciones e IC 95% de los artículos que reportaban IC en las medidas de asociación en MRM. También se calcularon las razones de porcentaje (RP) para describir el cambio en el reporte de los IC antes y después de la publicación de la declaración STROBE.

Resultados

188 de los 236 resúmenes con medidas de asociación (79,7%; IC 95% 74,5-84,8) y 360 de los 428 textos principales (84,1%; 80,6-87,6) estaban provistos de IC. Un incremento no significativo del 1% en el resumen, RP=1,01 (0,77-1,29), y del 7% en el texto principal, RP=1,07 (0,87-1,28), tuvo lugar en el reporte de los IC después de la publicación de la guía STROBE.

Conclusiones

La recomendación de reportar IC dada por la guía STROBE debería ser seguida más exhaustivamente.

Palabras clave:
Intervalo de confianza
P-valor
Guía STROBE

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