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Inicio Medicina Clínica (English Edition) Botulinum toxin in trigeminal neuralgia
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Vol. 148. Issue 1.
Pages 28-32 (January 2017)
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Vol. 148. Issue 1.
Pages 28-32 (January 2017)
Review
DOI: 10.1016/j.medcle.2017.01.005
Botulinum toxin in trigeminal neuralgia
Toxina botulínica en la neuralgia del trigémino
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Federico Castillo-Álvarez
Corresponding author
fcastilloa@riojasalud.es

Corresponding author.
, Ignacio Hernando de la Bárcena, María Eugenia Marzo-Sola
Servicio de Neurología, Hospital San Pedro, Logroño, La Rioja, Spain
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Tables (3)
Table 1. Summary of cases published in the medical literature.
Table 2. Summary of open studies published in the medical literature.
Table 3. Summary of placebo-controlled trials published in the medical literature.
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Abstract
Introduction

Trigeminal neuralgia is one of the most disabling facial pain syndromes, with a significant impact on patients’ quality of life. Pharmacotherapy is the first choice for treatment but cases of drug resistance often require new strategies, among which various interventional treatments have been used. In recent years a new therapeutic strategy consisting of botulinum toxin has emerged, with promising results.

Development

We reviewed clinical cases and case series, open-label studies and randomized clinical trials examining the use of botulinum toxin for drug-refractory trigeminal neuralgia published in the literature.

Conclusions

The administration of botulinum toxin has proven to be a safe and effective therapeutic strategy in patients with drug-refractory idiopathic trigeminal neuralgia, but many questions remain unanswered as to the precise role of botulinum toxin in the treatment of this disease.

Keywords:
Trigeminal neuralgia
Botulinum toxin
Onabotulinumtoxin A
Neuropathic pain
Treatment
Drug-refractory
Resumen
Introducción

La neuralgia del trigémino es uno de los síndromes de dolor facial más incapacitantes, con un importante impacto sobre la calidad de vida. Su tratamiento inicialmente es farmacológico, pero a menudo se presentan casos de farmacorresistencia que obligan a buscar nuevas estrategias, entre las que se han utilizado diversos tratamientos intervencionistas. En los últimos años ha surgido una nueva estrategia terapéutica consistente en el uso de toxina botulínica, con resultados prometedores.

Desarrollo

Se han revisado los casos clínicos y las series de casos, los estudios abiertos y los ensayos clínicos aleatorizados publicados sobre el uso de la toxina botulínica en el tratamiento de la neuralgia del trigémino farmacorresistente.

Conclusiones

La administración de toxina botulínica ha mostrado ser una estrategia terapéutica segura y efectiva en pacientes con neuralgia del trigémino farmacorresistente idiopática, pero quedan por responder numerosas cuestiones que terminen de situar su papel dentro de la terapéutica de esta enfermedad.

Palabras clave:
Neuralgia del trigémino
Toxina botulínica
Onabotulinumtoxin A
Dolor neuropático
Tratamiento
Farmacorresistente

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