Buscar en
Cirugía Española (English Edition)
Toda la web
Inicio Cirugía Española (English Edition) Incidence and risk factors for de novo cholelithiasis after bariatric surgery
Journal Information
Vol. 99. Issue 9.
Pages 648-654 (November 2021)
Share
Share
Download PDF
More article options
ePub
Visits
0
Vol. 99. Issue 9.
Pages 648-654 (November 2021)
Original article
Incidence and risk factors for de novo cholelithiasis after bariatric surgery
Incidencia y factores de riesgo para el desarrollo de colelitiasis tras cirugía bariátrica
Visits
...
Ainhoa Andrés-Imaz
Corresponding author
, Laura Martí-Gelonch, Emma Eizaguirre-Letamendia, José Ignacio Asensio-Gallego, José María Enríquez-Navascués
Servicio de Cirugía General y Digestiva, Hospital Universitario Donostia, Donostia, Gipuzkoa, Spain
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (4)
Show moreShow less
Tables (2)
Table 1. Comparison of clinical characteristics between the two groups.
Table 2. Kaplan–Meier analysis of the sample studied (n = 280) showing the incidence of de novo symptomatic cholelithiasis and its confidence intervals over time.
Show moreShow less
Abstract
Introduction

Obesity and rapid weight loss after bariatric surgery (BS) are risk factors for the development of cholelitiasis. The aim of this study is to know the incidence of the de novo symptomatic cholelitiasis (DNSC) after BS and to analyze the risk factors for its development.

Methods

Single-centre retrospective observational study of patients undergoing BS between January 2010 and December 2017. The incidence of DNSC has been studied and sex, age, comorbilities, surgical tecnique, initial BMI and percentage of excess BMI lost (%EBMIL) at 6th, 12th and 24th postoperative months have been analyzed.

Results

Among the 415 patients who underwent BS, 280 have been studied since they were not previously cholecystectomized and had a preoperative negative abdominal ultrasound. Twenty-nine developed DNSC (10,35%), with a remarkably higher increase in cumulative incidence during the first postoperative year (CI 5%, IC 95% 2,4–7,6). A higher percentage of excess BMI lost at the 6, 12 and 24 postoperative months was statistically significantly correlated with an increased risk of DNSC.

Conclusions

Incidence of DNSC and cholecystectomy after BS are relatively high, mainly during rapid weight loss period and even more the higher the percentage of excess BMI lost is. Concomitant cholecystectomy during BS in case of preoperative cholelithiasis regardless of symptoms and the use of ursodeoxycholic acid during the period of greater risk for DNSC development are two therapeutic options to consider.

Keywords:
Obesity
Bariatric surgery
Cholelithiasis
Ursodeoxycholic acid
Resumen
Introducción

La obesidad y la rápida pérdida de peso tras cirugía bariátrica (CB) son factores de riesgo para la formación de colelitiasis. El objetivo de este trabajo es conocer la incidencia de colelitiasis de novo sintomática (CLNS) tras CB y analizar los factores de riesgo para su desarrollo.

Métodos

Estudio observacional retrospectivo unicéntrico de los pacientes sometidos a CB entre Enero de 2010 y Diciembre de 2017. Se ha estudiado la incidencia de CLNS y se han analizado el género, la edad, las comorbilidades, la técnica quirúrgica, el IMC inicial y el % exceso de IMC perdido (%EIMCP) al 6°, 12° y 24° mes postoperatorio.

Resultados

De los 415 pacientes intervenidos de CB, 280 han sido estudiados ya que no estaban colecistectomizados previamente y tenían una ecografía preoperatoria negativa para colelitiasis. Veintinueve desarrollaron CLNS (10,35%), con un aumento en la incidencia acumulada notablemente más alto durante el primer año postoperatorio (IA 5%, IC 95% 2,4–7,6). Un mayor %EIMCP al 6°, 12°, 24° mes postoperatorio se correlacionó de forma estadísticamente significativa con un mayor riesgo de CLNS.

Conclusiones

La incidencia de CLNS y colecistectomía tras CB es relativamente alta, principalmente durante el periodo de pérdida de peso rápida y más cuanto mayor sea el %EIMCP. La colecistectomía concomitante en caso de colelitiasis preoperatoria independientemente de la sintomatología y el uso de ácido ursodesoxicólico durante el periodo de mayor riesgo para el desarrollo de CLNS son dos opciones terapéuticas a tener en cuenta.

Palabras clave:
Obesidad
Cirugía bariátrica
Colelitiasis
Ácido ursodesoxicólico

Article

These are the options to access the full texts of the publication Cirugía Española (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Cirugía Española (English Edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos