Buscar en
Archivos de la Sociedad Española de Oftalmología (English Edition)
Toda la web
Inicio Archivos de la Sociedad Española de Oftalmología (English Edition) The association between intestinal microbiome and autoimmune uveitis
Journal Information
Vol. 97. Issue 5.
Pages 264-275 (May 2022)
Share
Share
Download PDF
More article options
ePub
Visits
0
Vol. 97. Issue 5.
Pages 264-275 (May 2022)
Review
The association between intestinal microbiome and autoimmune uveitis
La asociación entre microbioma intestinal y uveítis autoinmune
Visits
...
D. Kalogeropoulosa,
Corresponding author
dkalog1990@gmail.com

Corresponding author.
, R. Barryb,c, C. Kalogeropoulosa
a Department of Ophthalmology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece
b Institute of Clinical Sciences, University of Birmingham, College of Medical and Dental Sciences, Birmingham, United Kingdom
c Department of Ophthalmology, Birmingham & Midland Eye Centre, Sandwell & West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Abstract
Introduction and objectives

The microbiome is strongly implicated in a wide spectrum of immune-mediated diseases, whereas gut commensal microbiota plays a pivotal role in immune and intestinal homeostasis.

Materials and methods

A thorough literature search was performed in PubMed database. An additional search was made in Google Scholar to complete the collected items.

Results

Due to complex interactions with the host genetics and other factors, intestinal dysbiosis has been linked to various immune-mediated disorders. In particular, the role of intestinal microbiota in the pathogenesis of uveitis has been demonstrated by several studies, indicating that changes in the microbiome can trigger autoimmune ocular inflammatory processes or affect their severity.

Conclusions

This review summarizes how alterations in the intestinal microbiota can conduce to immune-mediated ocular pathologies and how microbiome can be targeted in order to form novel therapeutic approaches to treat these severe and potentially blinding conditions.

Keywords:
Microbiome
Uveitis
Autoimmune diseases
Homeostasis
Antibiotics
Resumen
Introducción y objetivos

El microbioma está fuertemente implicado en un amplio espectro de enfermedades inmunomediadas, mientras que la microbiota comensal intestinal juega un papel fundamental en la homeostasis inmunológica e intestinal.

Materiales y métodos

Se realizó una búsqueda exhaustiva de la literatura en la base de datos PubMed. Se realizó una búsqueda adicional en Google Scholar para completar los elementos recopilados.

Resultados

Debido a las complejas interacciones con la genética del huésped y otros factores, la disbiosis intestinal se ha relacionado con varios trastornos inmunomediados. En particular, el papel de la microbiota intestinal en la patogenia de la uveítis ha sido demostrado por varios estudios, lo que indica que los cambios en el microbioma pueden desencadenar procesos inflamatorios oculares autoinmunes o afectar su gravedad.

Conclusiones

Esta revisión resume cómo las alteraciones en la microbiota intestinal pueden conducir a patologías oculares inmunomediadas y cómo el microbioma puede ser dirigido para formar nuevos enfoques terapéuticos para tratar estas condiciones severas y potencialmente cegadoras.

Palabras clave:
Microbioma
Uveítis
Enfermedades autoinmunes
Homeostasis
Antibióticos

Article

These are the options to access the full texts of the publication Archivos de la Sociedad Española de Oftalmología (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Archivos de la Sociedad Española de Oftalmología (English Edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos