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Vol. 88. Issue 9.
Pages 352-358 (September 2013)
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Vol. 88. Issue 9.
Pages 352-358 (September 2013)
Original article
Normal macular thickness and volume using spectral domain optical coherence tomography in a reference population
Espesor y volumen macular normal, mediante tomografía de coherencia óptica de dominio espectral, en nuestra población de referencia
L. Solé González, R. Abreu González??
Corresponding author

Corresponding author.
, M. Alonso Plasencia, P. Abreu Reyes
Servicio de Oftalmología, Hospital Universitario Nuestra Señora de La Candelaria, Tenerife, Spain
Article information
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Figures (1)
Tables (6)
Table 1. Table summary of demographic variables: age and sex; and clinical variables: arterial hypertension, dyslipidemia, diabetes mellitus and tobacco smoking; and variables on the correct execution of the test: signal strength, vertical foveal section and horizontal foveal section.
Table 2. Results of macular thickness and volume by sex.
Table 3. Results of macular thickness and volume by age groups.
Table 4. Results of macular thickness and volume by sex in each age group.
Table 5. Characteristics of included studies.
Table 6. Mean normality values for each SD-OCT device according to the studies included in the review.
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To establish normal values of macular thickness and volume obtained by the Cirrus SD-OCT (Carl ZeissMeditec, Dublin, CA, USA). Secondly, to assess the association between macular thickness and volume, sex and age.

Material and methods

A prospective study was conducted on patients who were seen in a hospital Retina Unit, and who only had retinal disease in one eye. All the Macular Cube 512×128 scan protocols were performed by the same operator. Only the healthy eye was scanned in each patient.


A total of 100 eyes of 100 patients were analysed. The mean central foveal thickness was 261.31±17.67μm, and was significantly (p<.05) higher in males (267.74±16.98μm) than in females (255.60±16.40μm). The mean obtained for the volume of the cube was 10.09±0.37mm 3, and the mean thickness of 280.33±10.34 cube um, with no statistically significant differences between gender being found (p<.05). The mean macular thickness is less at central level, increases in the inner perifoveal ring, and then decreases in the outer perifoveal ring. Furthermore, of all quadrants the greatest thickness was the nasal (328.27±12.96μm), followed by the upper (326.27±11.89μm), lower (322.53±12.37mm) sectors, with the temporal sector being the thinnest (313.35±14.20μm). The mean age of the patients was 60.86±14 years.


The mean central foveal thickness and the thickness of the inner perifoveal ring are significantly higher in men than in women. Both the mean volume and thickness of the cube, as well as nasal and inner superior sectors decrease with age, being significant only in women.

Macular thickness
Macular volume
Optical coherence tomography
Spectral domain

Establecer los valores de normalidad de espesor y volumen macular obtenidos mediante SD-OCT Cirrus (Carl ZeissMeditec, Dublín, CA, EE. UU.). Secundariamente, evaluar la asociación entre espesor y volumen macular, sexo y edad.

Material y método

Estudio prospectivo, con pacientes que fueron visitados en la unidad de retina del HUNSC y solo presentaban enfermedad retiniana en uno de los ojos. Todos los protocolos Macular Cube 512×128 fueron realizados por un mismo operador. De cada paciente, solo se analizó el ojo sano.


Se analizaron 100 ojos de 100 pacientes. El espesor foveal central medio fue 261,31±17,67μm, siendo significativamente (p<0,05) mayor en hombres (267,74±16,98μm) que en mujeres (255,60±16,40μm). La media obtenida para el volumen del cubo fue de 10.09±0.37mm3 y para el espesor medio del cubo de 280.33±10.34μm; no encontrando diferencias estadísticamente significativas entre sexos (p<0,05). El espesor macular medio es menor a nivel central, aumenta en el anillo perifoveal interno y disminuye a continuación en el anillo perifoveal externo. Asimismo, de todos los cuadrantes el de mayor espesor es el nasal (328,27±12,96μm), seguido del superior (326,27±11,89μm), inferior (322,53±12,37μm) y por último, el de menor espesor es el temporal (313,35±14,20μm). La edad media de los pacientes incluidos es de 60,86±14 años.


El espesor foveal central medio y el espesor del anillo perifoveal interno son significativamente mayores en hombres que en mujeres. Tanto el volumen como el espesor medio del cubo, así como los sectores nasales y el sector supero interno, decrecen con la edad, únicamente de forma significativa en las mujeres.

Palabras clave:
Valores normales
Espesor macular
Volumen macular
Tomografía de coherencia óptica
Dominio espectral


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