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Journal Information
Vol. 90. Issue 3.
Pages 112-118 (March 2015)
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Vol. 90. Issue 3.
Pages 112-118 (March 2015)
Original article
DOI: 10.1016/j.oftale.2015.03.010
Comparative study of the efficacy of different treatment options in patients with chronic blepharitis
Estudio comparativo de la eficacia de diversas modalidades terapéuticas en pacientes con blefaritis crónica
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M. Arrúaa, M. Samudioa,
Corresponding author
microbiologia@iics.una.py

Corresponding author.
, N. Fariñaa, D. Cibilsa, F. Laspinaa, R. Sanabriaa, L. Carpinellia, H. Mino de Kasparb
a National University of Asunción, Asunción, Paraguay
b Ludwig-Maximilians University, Munich, Germany
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Figures (2)
Tables (5)
Table 1. General characteristics of patients with chronic blepharitis.
Table 2. Signs and symptoms of patients with chronic blepharitis.
Table 3. Inter-group comparison of the baseline average scores on symptoms and signs of patients with chronic blepharitis.
Table 4. Inter-group comparison of the average scores on symptoms and signs of patients with chronic blepharitis before and after treatment.
Table 5. Inter-group comparison of the average scores on symptoms and signs of patients with chronic blepharitis 2 months after treatment.
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Abstract
Objective

To compare the efficacy of 3 treatment options in patients with chronic blepharitis.

Methodology

An experimental, randomized, controlled study was conducted on 45 patients (female 67%; mean age: 40.5 years) diagnosed with chronic blepharitis, in order to compare the effectiveness of three treatment options. Group 1: eyelid hygiene with neutral shampoo three times/day; group 2: neutral shampoo eyelid hygiene plus topical metronidazole gel 0.75% twice/day; group 3: neutral eyelid hygiene with shampoo plus neomycin 3.5% and polymyxin 10% antibiotic ointment with 0.5% dexamethasone 3 times/day. The symptoms and signs were assessed by assigning scores from 0: no symptoms and/or signs; 1: mild symptoms and/or signs, 2: moderate symptoms and/or signs; and 3: severe symptoms and/or signs.

Results

A significant improvement was observed in the signs and symptoms in all 3 treatment groups. While groups 1 and 2 had more improvement in all variables studied (P<.05), Group 3 showed no clinical improvement for itching (P=.16), dry eye (P=.29), eyelashes falling (P=.16), and erythema at the eyelid margin (P=.29).

Conclusions

Shampoo eyelid hygiene neutral and neutral shampoo combined with the use of metronidazole gel reported better hygiene results than neutral shampoo lid with antibiotic ointment and neomycin and polymyxin dexamethasone.

Keywords:
Chronic blepharitis
Demodex folliculorum
Metronidazole gel
Eyelid hygiene
Neutral shampoo
Resumen
Objetivo

Comparar la eficacia de 3 modalidades de tratamiento en pacientes con blefaritis crónica.

Metodología

Se realizó un estudio experimental, aleatorizado y controlado en 45 pacientes (sexo femenino: 67%; edad media: 40.5 años) con diagnóstico de blefaritis crónica para comparar la eficacia de 3 modalidades de tratamiento. Grupo 1: higiene palpebral con champú neutro 3 veces/día; grupo 2: higiene palpebral con champú neutro y gel tópico de metronidazol al 0,75% 2 veces/día; grupo 3: higiene palpebral con champú neutro y pomada antibiótica de neomicina al 3,5% y polimixina al 10% con dexametasona al 0,5% 3 veces/día. Los síntomas y signos fueron valorados asignándoles puntuaciones entre 0: sin síntomas ni signos; 1: síntomas o signos leves; 2: síntomas o signos moderados y 3: síntomas o signos severos.

Resultados

En los 3 grupos de tratamiento se observó mejora significativa de los signos y síntomas. Mientras que los grupos 1 y 2 presentaron una mayor mejoría en todas las variables estudiadas (p<0,05), el grupo 3 no presentó mejoría clínica para comezón (p=0,16), ojo seco (p=0,29), caída de pestañas (p=0,16) ni eritema en el borde palpebral (p=0,29).

Conclusión

La higiene palpebral con champú neutro y el uso combinado de champú neutro con gel de metronidazol reportaron mejores resultados que la higiene palpebral con champú neutro y pomada antibiótica de neomicina y polimixina con dexametasona.

Palabras clave:
Blefaritis crónica
Demodex folliculorum
Gel de metronidazol
Higiene palpebral
Champú neutro

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