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Available online 11 February 2024
Achromobacter xylosoxidans keratitis in a LASIK flap treated with intrastromal antibiotics: a case report
Queratitis por Achromobacter xylosoxidans en flap de LASIK tratada con antibióticos intraestromales: a propósito de un caso
N. Castro Casal
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nerea.castro.casal@sergas.es

Corresponding author.
, S. Viña Vázquez, S. Romeo Villadóniga
Servicio de Oftalmología, Complexo Hospitalario Universitario de Ferrol, A Coruña, Spain
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Abstract

Intrastromal antibiotic injections are a type of treatment that can be very useful in bacterial keratitis refractory to topical antibiotics. We present the case of a 44-year-old woman with an infiltrate in a laser in situ keratomiuleusis (LASIK) flap and growth of Achromobacter xylosoxidans, who was treated with topical ceftazidime for 1 month. However, after discontinuation of the antibiotic, there was a worsening with growth of the same germ. Topical treatment was reintroduced and, due to suspicion of germ reservoir, it was decided to give three cycles of intrastromal ceftazidime injections, the last one also with moxifloxacin, with good results. After 4 months asymptomatic and without treatment at the moment, no signs of recurrence have been observed. This case supports the usefulness of intraestromal injections in refractory cases to the topical medication.

Keywords:
Keratitis
Achromobacter xylosoxidans
LASIK
Intraestromal antibiotics
Resumen

Las inyecciones intraestromales de antibióticos son un tipo de tratamiento que puede ser de gran utilidad en queratitis bacterianas refractarias a antibióticos tópicos. Presentamos el caso de una mujer de 44 años con un infiltrado en un flap de queratomileusis in situ asistida con láser (LASIK) y crecimiento de Achromobacter xylosoxidans, que se trató con ceftazidima tópica durante 1 mes. Sin embargo, tras la suspensión del antibiótico, se produjo un empeoramiento con crecimiento del mismo germen. Se reintrodujo el tratamiento tópico y, ante la sospecha de acantonamiento del germen, se decidió poner tres ciclos de inyecciones de ceftazidima intraestromal, el último también con moxifloxacino, con buen resultado. Tras 4 meses asintomática y sin tratamiento actualmente, no se han observado signos de recidiva. Este caso respalda la utilidad de las inyecciones intraestromales en casos refractarios a la vía tópica.

Palabras clave:
Queratitis
Achromobacter xylosoxidans
LASIK
Antibióticos intraestromales

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