ISSN: 1665-2681

Annals of Hepatology (AoH) is an international, open access journal published bi-monthly with funds from the Fundación Clínica Médica Sur. It is the official journal of the Mexican Association of Hepatology (AMH), the Latin American Association for the Study of the Liver (ALEH), the Canadian Association for the Study of the Liver (CASL) and the Czech Society of Hepatology (CSH). AoH publishes editorials, opinions, concise reviews, original articles, brief reports, letters to the editor, news from affiliated associations, clinical practice guidelines and summaries of congresses in the field of Hepatology.

Topics covered by AoH include alcoholic liver disease, autoimmune hepatitis, biliary diseases, drug-induced liver injury, genetic liver diseases, NAFLD/NASH and viral hepatitis (HAV, HBV, HCV, HDV, HEV). Our journal seeks to publish articles on basic clinical care and translational research focused on preventing rather than treating the complications of end-stage liver disease.

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Brief report

A putative hepatitis B virus sequence motif associated with hepatocellular carcinoma in South African adults

Tongai G. Mapongaa,b,†, Anna L. McNaughtonc,†, Cori Campbellc, Mariateresa de Cesarec, Jolynne Mokayad, Sheila F. Lumleyc,e, David Bonsallc,e,f, Camilla LC Ipc, Haiting Chaic, Christo Van Rensburgg, Richard H. Glashoffb,h, Elizabeth Waddilovei, Wolfgang Preisera,b, Jason T. Blackardj, M. Azim Ansaric, Anna Kramvisk, Monique I. Anderssona,c,e, Philippa C Matthewsi,l,m,

Corresponding author

philippa.matthews@crick.ac.uk

Corresponding author.

a Division of Medical Virology, Stellenbosch University, Faculty of Medicine and Health Sciences, Tygerberg, Cape Town, South Africa

b National Health Laboratory Service, Tygerberg Business Unit, Tygerberg, Cape Town, South Africa

c Nuffield Department of Medicine, University of Oxford, Oxford, UK

d Parasites and Microbes, Wellcome Sanger Institute, Hinxton, UK

e Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK

f Big Data Institute, Old Road, Oxford OX3 7FZ, UK

g Division of Gastroenterology, Stellenbosch University, Faculty of Medicine and Health Sciences, Tygerberg, Cape Town, South Africa

h Immunology Unit, Division of Medical Microbiology, Stellenbosch University, Faculty of Medicine and Health Sciences, Tygerberg, Cape Town, South Africa

i The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK

j University of Cincinnati College of Medicine, Cincinnati, OH, USA

k Hepatitis Virus Diversity Research Unit, Department of Internal Medicine, University of the Witwatersrand, 7 York Road, Parktown, 2193 Johannesburg, South Africa

l Division of Infection and Immunity, University College London, Gower Street, London WC1E 6BT, UK

m Department of Infectious Diseases, University College London Hospital, Euston Road, London NW1 2BU, UK

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