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Inicio Allergologia et Immunopathologia Impaired in-vitro responses to IL-12 and IFN-γ in Iranian patients with Mendeli...
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Vol. 43. Issue 5.
Pages 456-460 (September - October 2015)
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Vol. 43. Issue 5.
Pages 456-460 (September - October 2015)
Original article
DOI: 10.1016/j.aller.2014.05.008
Impaired in-vitro responses to IL-12 and IFN-γ in Iranian patients with Mendelian susceptibility to mycobacterial disease
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N. Parvaneha,b, B. Pourakbarib, N. Rezaeic,d, A. Omidvarb, F. Sabounia, S. Mahmoudib, G. Khotaeia, S. Mamishia,b,
Corresponding author
smamishi@sina.tums.ac.ir

Corresponding author.
a Department of Infectious Disease, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
b Pediatric Infectious Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran
c Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
d Molecular Immunology Research Center; and Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
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Table 1. Characteristics of enrolled patients who were suspected of having MSMD.
Table 2. In vitro production of IFN-γ and IL-12p40 levels after different stimuli in patients with MSMD and control subjects.
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Abstract
Introduction

Diagnosis of specific molecular defects of Mendelian susceptibility to mycobacterial diseases (MSMD) patients is important with respect to their clinical outcomes and their response to therapy. The aim of this study was to perform functional tests on blood samples of a group of patients who were suspected of having MSMD.

Methods

This study was performed on 11 cases who had mycobacterial infections and suspected MSMD. Whole blood cell culture was performed in presence of different stimulators. The supernatants were assayed for IFN-γ, IL-12p40 by ELISA method.

Results

All patients presented with complications of BCG vaccine in the form of localised lymphadenitis or disseminated BCG infection and chronic mycobacterial osteomyelitis. Infections with Salmonella species occurred in two patients. In-vitro studies showed that 10 cases had impaired response to IL-12. However, the baseline levels of IL-12p40 were normal, while one of our patients may have a potential IFN-γ signalling defect or an IL-12p40 defect.

Conclusions

Early detection of MSMD and commencing of appropriate combination therapy could prevent severe or even fatal complications of uncontrolled mycobacterial infections.

Keywords:
Immunodeficiency
Mendelian susceptibility to mycobacterial diseases
Mycobacterial diseases

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