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Vol. 43. Issue 5.
Pages 477-481 (September - October 2015)
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Vol. 43. Issue 5.
Pages 477-481 (September - October 2015)
Original Article
DOI: 10.1016/j.aller.2014.06.007
Comparison of major lymphocyte subpopulations and recent thymic emigrants in patients with ataxia telangiectasia and age-matched healthy groups
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M.H. Celiksoya,
Corresponding author
drmhc@hotmail.com

Corresponding author.
, E. Topalb, A. Yıldırana
a Ondokuz Mayıs University, Medical Faculty, Department of Pediatric Allergy and Immunology, Samsun, Turkey
b Inonu University, Medical Faculty, Department of Pediatric Allergy and Immunology, Malatya, Turkey
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Tables (3)
Table 1. Demographics of patients with ataxia telangiectasia.
Table 2. Major lymphocyte subpopulations of patients with ataxia telangiectasia according to age groups.
Table 3. Comparison of major lymphocyte subpopulations and recent thymic emigrants in patients with ataxia telangiectasia and age-matched healthy groups.
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Abstract
Background

Ataxia telangiectasia (A-T) is a genetic disorder caused by the homozygous mutation of the A-T mutated gene. It is frequently associated with variable degrees of cellular and humoral immunodeficiency. However, the immune defects in A-T patients are not well characterized. To the best of our knowledge, no studies have focused on the major lymphocyte subpopulations and recent thymic emigrants of A-T patients in comparison with age-matched healthy controls.

Methods

Following the European Society for Immunodeficiencies criteria, 17 patients diagnosed with A-The, and 12 age-matched healthy children were assigned to the study. Both patients and healthy controls were grouped as 1–5, 6–10, 11–15, and 15+ years. By using a flow cytometer, major lymphocyte subpopulations and CD4+CD45RA+CD31+ recent thymic emigrants were determined as percentage and absolute cell numbers and compared.

Results

No significant differences in all lymphocyte subpopulations were observed between the age groups of A-T patients. Compared to the healthy controls, there was a decrease in T cells, effector memory T4 cells, B cells, naïve B cells, naïve T4 cells, switched B cells, and recent thymic emigrants and an increase in active T8 cells and non-switched B cells in the percentage and absolute number of some cell populations in the A-T group.

Conclusions

This study showed that effector functions in some cell lymphocyte populations were decreased in A-T patients.

Keywords:
Ataxia–telangiectasia
CD31
Immunodeficiency
Lymphocyte subpopulation
PECAM-1
Recent thymic emigrants

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