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Inicio Allergologia et Immunopathologia Contact urticaria on eczematous skin by kiwifruit allergy. In vivo component-res...
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Vol. 43. Issue 5.
Pages 474-476 (September - October 2015)
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Vol. 43. Issue 5.
Pages 474-476 (September - October 2015)
Original Article
DOI: 10.1016/j.aller.2014.07.006
Contact urticaria on eczematous skin by kiwifruit allergy. In vivo component-resolved diagnosis
Stefano Miceli Sopo
Corresponding author

Corresponding author.
, Claudia Fantacci, Ilaria Sani
Department of Pediatrics, Agostino Gemelli Hospital, Catholic University of Sacred Heart, Rome, Italy
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Tables (1)
Table 1. In vivo allergy tests.

Kiwifruit allergy has been responsible for a variety of clinical manifestations, ranging from mild reactions, such as localised oral symptoms, to severe systemic symptoms, such as anaphylaxis. No cases of isolated contact urticaria (ICU) due to IgE-mediated allergy to kiwifruit have been reported in the literature so far. Here we describe the first three cases of ICU due to kiwi and we hypothesise about a kiwifruit allergen not described yet.


Using the available in vivo allergy tests, we performed a component-resolved diagnosis to detect the allergen involved. All the patients underwent prick-by-prick with raw and boiled kiwi pulp and latex glove, skin prick test with commercial extracts of kiwifruit, birch, latex, palm profilin and peach lipid transfer protein, rub test with raw and boiled kiwi and oral food challenges with the raw fruit.


We found that, in our patients, the kiwifruit allergen responsible for ICU is thermolabile, gastrosensitive, and it does not show any of the most common kiwi-attributed cross-reactivity (latex, birch, profiling and lipid transfer protein). None of the 13 kiwifruit allergens already known shows all these features.


Kiwifruit allergy can also occur with ICU, probably due to a native protein that is not yet identified. In this case the elimination diet is not required.

Contact urticaria
Food allergy
Kiwi fruit


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