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Vol. 48. Issue 1.
Pages 84-89 (January - February 2020)
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Vol. 48. Issue 1.
Pages 84-89 (January - February 2020)
Original Article
DOI: 10.1016/j.aller.2019.06.016
Associations between serum 25-hydroxyvitamin D levels and allergic sensitization in early childhood
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Y. Guoa, L. Yua, Y.-H. Dengb, H.-J. Kea, J.-L. Wua,
Corresponding author
jieling3861@163.com

Corresponding author.
a Department of Children’s Health Care, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou 511400, China
b School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, China
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Tables (3)
Table 1. Participants’ characteristics by 25(OH)D levels in children aged 1 and 2 years.
Table 2. Prevalence of positive serum antigen-specific IgE tests by serum 25(OH)D levels in children aged 1 and 2 years.
Table 3. Associations between antigen-specific IgE levels and 25(OH)D levels in children aged 1 and 2 years.
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Abstract
Background and objectives

Vitamin D status may be related to allergen sensitizations, but the evidence is inconsistent. The objective of this study was to assess whether serum 25-hydroxyvitamin D (25(OH)D) levels were associated with allergic sensitizations in early childhood.

Methods

Data were collected from 2642 children who visited the Guangdong Women and Children’s Hospital from January 2016 to May 2017 for routine health check-ups. Serum 25(OH)D levels were tested by electrochemiluminescence immunoassay. Allergic sensitizations including food and inhalant allergens were tested for specific IgE antibodies at one year (12 months 0 days through 12 months 30 days) and two years (24 months 0 days through 24 months 30 days) of age.

Results

The mean level of serum 25(OH)D was 86.47±27.55nmol/L, with a high prevalence of vitamin D insufficiency (<75nmol/L) in children aged 0–2 years (36.8%). Lower 25(OH)D levels with serum total IgE of more than 200IU/mL (81.54±25.53nmol/L) compared with less than 100IU/mL (87.92±28.05nmol/L). The common sensitization to allergens in children aged one and two years were milk (44.2%), cat epithelium (26.4%), egg (13.1%), dog epithelium (12.7%) and Dermatophagoides farinae (6.7%). After multivariate adjustment, data in 25(OH)D treated as a continuous variable or categories, no consistent associations were found between 25(OH)D levels and allergen-specific IgEs.

Conclusions

Serum 25(OH)D level showed an inverse relationship with total IgE level in early childhood. However, there is lack of evidence to support associations between low 25(OH)D levels and allergic sensitization to various allergens.

Keywords:
Allergy
Allergic sensitization
Vitamin D

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