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Vol. 47. Issue 6.
Pages 591-597 (November - December 2019)
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Vol. 47. Issue 6.
Pages 591-597 (November - December 2019)
Original Article
DOI: 10.1016/j.aller.2019.05.002
The relation between serum vitamin D levels, viral infections and severity of attacks in children with recurrent wheezing
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Cemal Eroglua, Faruk Demirb, Duygu Ergeb,
Corresponding author
duyguolmez@hotmail.com

Corresponding author at: Adnan Menderes University Hospital, Department of Pediatric Allergy and Immunology, Hasan Efendi District, Hospital Street, 09100, Aydin, Turkey.
, Pinar Uysalb, Sevin Kirdarc, Mustafa Yilmazd, Imran Kurt Omurlue
a Adnan Menderes University, Faculty of Medicine, Department of Pediatrics, Aydin, Turkey
b Adnan Menderes University, Faculty of Medicine, Department of Pediatric Allergy and Immunology, Aydin, Turkey
c Adnan Menderes University, Faculty of Medicine, Department of Microbiology, Aydin, Turkey
d Adnan Menderes University, Faculty of Medicine, Department of Biochemistry, Aydin, Turkey
e Adnan Menderes University, Faculty of Medicine, Department of Biostatistics, Aydin, Turkey
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Tables (6)
Table 1. Sociodemographic characteristics of patient and control groups.
Table 2. Comparison of patient and control group for wheezing risk factors.
Table 3. Biochemical data of the patient and the control group.
Table 4. Results of forward stepwise logistic regression analysis for predicting risk of wheezing.
Table 5. Comparison of vitamin D levels according to the factors that may indicate the severity of wheezing attack.
Table 6. The distribution of respiratory viruses in patients.
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Abstract
Introduction and Objectives

Vitamin D deficiency is associated with increased susceptibility to infections and wheezing. We aimed to evaluate the relation between vitamin D levels, viral infections and severity of attacks in children with recurrent wheezing.

Materials and methods

A total of 52 patients who applied with wheezing, at the ages of 12–60 months with a history of three or more wheezing attacks in the last year and 54 healthy children were included. Sociodemographic data, risk factors for recurrent wheezing, and the severity of the wheezing attacks were recorded. 25(OH)D3, calcium, phosphor, alkaline phosphatase and parathormone levels of all children were measured. Nasopharyngeal samples of the patients for viruses were studied by multiplex polymerase chain reaction.

Results

For the patient group, being breastfed for six months or less, history of cesarean section, cigarette exposure, humid home environment, and family history of allergic disease were significantly higher compared with the control group. Serum vitamin D levels in the patient group were significantly lower compared to the control group. There was no significant relationship between vitamin D levels and hospitalization, oxygen or steroid therapy. Virus was detected in 38 patients (73%). Rhinovirus (63.2%) was the most frequently detected virus. Coinfection was found in 14 (36.8%) patients. There was no statistically significant difference between detection of virus and vitamin D levels.

Conclusions

Cigarette exposure, being breastfed six months or less, humid home environment, history of cesarean section, family history of allergic disease and vitamin D deficiency might be risk factors for recurrent wheezing.

Keywords:
Recurrent wheezing
Vitamin D
Virus
Polymerase chain reaction

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