Testosterona y antígeno prostático específico en pacientes con disfunción eréctil

Introduction: Prostatic Specific Antigen (PSA) levels are modify by the age. Testosterona (T) levels change with aging. No regional reports are available regarding the T levels, PSA and age in patients with Erectile Dysfunction (ED). Objective: To find the correlation between PSA, T serum levels and Age in patients with complains of ED in Chihuahua (Mexico). Patients and method: 192 files were reviewed, only 85 patients with ED complains had the information required, and were classified in two groups: hypogonadic Group (GH): nineteen patients with T level ≤ 300 ng/dl. Eugonadal Group (GN): sixty six patients with t level > 300 ng/dl. The data collected were age, total T and total PSA, using an Excel data base and analyzed using SPSS 10.0 statistic software with 95% CI. Results: The mean age of patients was: GH 49.2 years SD 13.2 (range 21-69); GN 45.6 years SD 13.2 (range, 19-80). The mean T level was: GH 226.6 ng/dl SD 64.2 (range, 38-300); GN 521.3 ng/dl SD 185.9 (range, 301-1270). The mean PSA was: GH 4.7 ng/ml SD 10.11 (range, 0.40-34.6); GN 1.3 ng/ml SD 1.13 (range, 0.2-7.9). Conclusions: The difference of T levels between 2 groups was statistically significant (p = 0.000 by Wilcoxon test). In this series no statistically significant difference was find in the mean age of patients between both groups (p = 0.14 by ANOVA). It is relevant to see highest PSA levels (4.7 ng/ml) in the GH than PSA levels of GN (1.3 ng/ml) p = 0.032 by χ² test. Strong statistically significant difference was find in PSA between two groups, after adjusting the Age (p = 0.027 by Spearman's rho Test). We are confirming the previous reports connecting hypogonadism with the probability of prostate cancer, also suggesting stronger efforts for discover this disease before hormonal replacement therapy.