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Inicio Revista Iberoamericana de Micología Burden of onychomycosis in rural India: Clinical and mycological assessment of t...
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Vol. 27. Núm. 3.
Páginas 152-153 (Julio - Septiembre 2010)
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Vol. 27. Núm. 3.
Páginas 152-153 (Julio - Septiembre 2010)
Letter to the Editor
DOI: 10.1016/j.riam.2010.05.002
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Burden of onychomycosis in rural India: Clinical and mycological assessment of the disease severity using Naildex score
Onicomicosis en la India rural: evaluación clínica y micológica de la enfermedad mediante el sistema de puntuación Naildex
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Peralam Yegneswaran Prakasha,
Autor para correspondencia
prakashpy123@yahoo.co.in

Corresponding author.
, Gurung Shrijanab, Bairy Indirab
a Kasturba Medical College, Manipal University, Manipal, Karnataka, India
b Microbiology, Manipal University, Manipal, Karnataka, India
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Tablas (3)
Table 1. Summary of onychomycosis cases screened by microscopy and culture
Table 2. Etiological agents involved with confirmed cases of onychomycosis
Table 3. Comparison between finger and toenail with duration of onychomycosis
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Sr. Director:

Onychomycosis denotes fungal infection of the nail characterized by thickening, splitting, roughening and discoloration of nail and accessory structures due to dermatophytes, non-dermatophyte moulds and few yeast genera.2 Onychomycosis can have a lasting adverse impact on patient's daily life, social functioning, physical and mental health; items collectively termed as “Quality of Life”.5 The predisposing factors range from advancing age, trauma, geo-climatic conditions, occupation, social class, immune status of the host and associated superficial mycoses like tinea pedis.1,3 Naildex score first applied by Warshaw et al.6 was used in this study to understand the burden of onychomycosis in agricultural workers in a rural community setting, and to assess the disease severity.

The study was conducted during October 2007 to October 2008 including three coastal villages in Karnataka, Southern India. 42 patients with clinical features of onychomycosis were screened for the disease. The nail and adjacent area was cleaned with 70% alcohol before collection with a nail clipper and tweezers onto pre-sterilized black kraft paper and portioned for KOH-calcofluor microscopy and fungal culture. The nail segments were briskly dipped in methanol to remove any bacterial contaminant and inoculated on Sabouraud dextrose agar with chloramphenicol and cycloheximide and Sabouraud dextrose agar with chloramphenicol and incubated at 28°C for 3 weeks. Identification of the filamentous/yeast fungi was done based on the macroscopic and microscopic features as per the standard mycological methods. A repeat sample was procured from all those patients who were both microscopy and culture positive case for confirmation of onychomycosis and Naildex score was recorded.

Among the 42 patients screened, 17 were positive by microscopy and culture, and 20 positive by microscopy alone. This included 13 females and 4 males. The results of microscopy and culture positive cases are shown in Table 1. The mean age of the females was 52 years and of the males was 49 years. Distal lateral subungual onychomycosis was seen in 9 patients, and 8 patients presented with total dystrophic onychomycosis. Toenails alone were affected in 10 patients, and fingernails only in 6 patients. Toenails and fingernails both were affected in 1 patient. The commonest isolate from the toenails was Fusarium solani, and that from the fingernails was Candida parapsilosis (Table 2). Naildex score was calculated for patients who yielded a positive microscopy and culture result. Mean of the scores – toenail and fingernail – was compared with the duration of the disease by the Independent Sample t-test, as depicted in Table 3.

Table 1.

Summary of onychomycosis cases screened by microscopy and culture

  MicroscopyTotal 
  Positive  Negative   
Culture
Positive  17  17 
Negative  22  25 
Total  20  22  42 
Table 2.

Etiological agents involved with confirmed cases of onychomycosis

Etiological agent involved  Site affected
  Toenail  Fingernail 
Trichophyton rubrum 
Trichophyton mentagrophytes 
Fusarium solani 
Acremonium spp. 
Paecilomyces 
Alternaria spp. 
Curvularia lunata 
Candida parapsilosis 
Table 3.

Comparison between finger and toenail with duration of onychomycosis

  Score mean±S.D.
  Toenail*  Fingernail** 
Duration years
≤5  0.221±0.098  0.164±0.010 
≥6  0.6043±0.272  0.660±0.085 
*

p-value=0.010.

**

p-value=0.002.

Various scoring methods have been devised to study the disease severity like the Planimetry method and the Global evaluation method.4 The Planimetry method is tedious and time consuming and it cannot distinguish minimal residual disease from cure. Both methods are imprecise.6 An increase in the score with an increase in duration of the disease was also seen in study done by Warshaw et al.6

This study highlights the burden of onychomycosis among agricultural workers in a rural setting. The Naildex scoring method is rapid and inexpensive and may have a significant role for testing new drugs in clinical trials and also may be used to assess the response to treatment of onychomycosis.

References
[1]
B.E. Elewski.
Onychomycosis: pathogenesis, diagnosis and management.
Clin Microbiol Rev, 11 (1998), pp. 415-429
[2]
D.H. Ellis, A.B. Watson, J.E. Marley, T.G. Williams.
Non-dermatophytes in onychomycosis of the toenails.
Br J Dermatol, 136 (1997), pp. 490-493
[3]
J. Faergemann, R. Baran.
Epidemiology, clinical presentation and diagnosis of onychomycosis.
Br J Dermatol, 149 (2003), pp. 1-4
[4]
A.K. Gupta, P. Fleckman, R. Baran.
Ciclopirox nail lacquer topical solution 8% in the treatment of toenail onychomycosis.
J Am Acad Dermatol, 43 (2000), pp. S70-S80
[5]
E.M. Warshaw, J.K. Foster, M.H. Cham, J.P. Grill, S.C. Chen.
NailQOL: a quality-of-life instrument for onychomycosis.
Int J Dermatol, 46 (2007), pp. 1279-1286
[6]
E.M. Warshaw, C.A. Traywick, A.A. Hoffman, K.K. Lilly, R.L. Koshnick, J.W. Robinson, et al.
Naildex: pilot evaluation of an onychodystrophy severity instrument.
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