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Inicio Revista Española de Geriatría y Gerontología El péptido β-amiloide: mecanismos de neurotoxicidad. neuroprotección por anti...
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Vol. 36. Núm. 2.
Páginas 109-116 (Enero 2001)
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Vol. 36. Núm. 2.
Páginas 109-116 (Enero 2001)
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El péptido β-amiloide: mecanismos de neurotoxicidad. neuroprotección por antioxidantes y estrógenos
Amyloid β-peptide: Mechanisms of Neurotoxicity. Neuroprotection by Antioxidants and Estrogens
F.J. Muñoz López**
Autor para correspondencia

Correspondencia: F. J. Muñoz López. Universitat Pompeu Fabra. Dr. Aiguader, 80. 08003 Barcelona. E-mail:
Departament de Cienciès Experimentals i de la Salut. Facultat de Cienciès de la Salut i de la Vida. Universitat Pompeu Fabra. Barcelona
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La enfermedad de Alzheimer (EA) se caracteriza por la muerte neuronal asociada a la presencia de placas seniles y ovillos neurofibrilares. El componente principal de las placas seniles es el péptido β- amiloide (Aβ) el cual es considerado como un inductor de la neurodegeneración observada en el cerebro de individuos con EA. El objetivo del presente trabajo es revisar el estado actual de la investigación básica sobre los mecanismos de acción neurotóxicos del Aβ, así como el efecto neuroprotector de los estrógenos y de distintos antioxidantes como la vitamina E y la melatonina.

Palabras clave:
Estrés oxidativo

The hallmarks of Alzheimer’s disease (AD) are neuronal death, senile plaques and neurofibrillary tangles. Senile plaques are mainly composed of amyloid β-peptide (Aβ) which is considered to trigger the neurodegeneration found in the brains of AD patients. The main goal of the present work is to review the proposed mechanisms which are involved in the Aβ-mediated cytotoxicity and the neuroprotective role of estrogens and antioxidants such as vitamin E and melatonin.

Key words:
Oxidative stress
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