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Inicio Revista Colombiana de Reumatología Enfermedad de Behcet: experiencia en una cohorte de pacientes colombianos
Información de la revista
Vol. 16. Núm. 1.
Páginas 33-45 (Marzo 2009)
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Vol. 16. Núm. 1.
Páginas 33-45 (Marzo 2009)
DOI: 10.1016/S0121-8123(09)70117-3
Acceso a texto completo
Enfermedad de Behcet: experiencia en una cohorte de pacientes colombianos
Behcet's disease: Experience in a Colombian cohort
Visitas
1489
Ana Milena Toro Giraldo1, Luis Fernando Pinto Peñaranda2, Carlos Jaime Velásquez Franco2, José Luis Torres Grajales3, Dora Liliana Candia Zúñiga4, Javier Darío Márquez Hernández2
1 Dermatóloga – Docente de dermatología, Universidad Pontificia Bolivariana, Medellín, Colombia
2 Reumatólogo del Hospital Pablo Tobón Uribe y Profesor Asociado de la Universidad Pontificia Bolivariana, Medellín, Colombia
3 Médico Internista del Hospital Pablo Tobón Uribe, Medellín, Colombia
4 Reumatóloga Clínica Universitaria Bolivariana, Medellín, Colombia
Información del artículo
Resumen
Introducción

la enfermedad de Behcet (EB) es una vasculitis multisistémica de causa desconocida, caracterizada por exacerbaciones y remisiones de duración impredecible. Los hallazgos clínicos incluyen: aftas orales y genitales, artritis, lesiones cutáneas, manifestaciones oculares, gastrointestinales y neurológicas. No se conoce adecuadamente, en nuestro medio, el curso clínico, la actividad y la gravedad de esta enfermedad.

Objetivos

el propósito de este estudio es describir el espectro clínico, la actividad y la gravedad de la enfermedad en un grupo de pacientes colombianos con EB.

Métodos

se realizó un estudio longitudinal, observacional, descriptivo y prospectivo, en una serie de pacientes con EB diagnosticados y seguidos por el servicio de reumatología en el Hospital Pablo Tobón Uribe en Medellín, Colombia.

Resultados

se identificaron 20 pacientes consecutivos (15 mujeres y cinco hombres) con una edad promedio de 42,1±11,2 años al diagnóstico. Las manifestaciones clínicas más frecuentes fueron las úlceras orales (95%) y genitales (75%), seguidas por el compromiso cutáneo (60%), ocular (55%), articular (45%), gastrointestinal (40%), vascular (15%) y neurológico (15%). La manifestación clínica inicial más frecuente fue la presencia de úlceras orales.

El tiempo promedio entre la primera manifestación y el cumplimiento de los criterios diagnósticos fue 4,45±4,19 años. El 50% de los pacientes se clasificaron como enfermedad moderada y el 35% como grave.

Conclusiones

la EB está subdiagnosticada en nuestro medio. Las úlceras mucocutáneas representan el principal hallazgo clínico y pueden preceder por mucho tiempo a otras manifestaciones, causando retraso en el diagnóstico y favoreciendo un comportamiento agresivo.

Palabras clave:
enfermedad de Behcet
vasculitis
manifestaciones cutáneas
manifestaciones orales
Summary
Background

Behcet's disease (BD) is a multisystemic vasculitis of unknown cause. It is characterized by exacerbations and remissions of unpredictable duration. The clinical findings include oral and genital aphtaes, arthritis, cutaneous lesions, ocular, gastrointestinal and neurological manifestations. In our environment, the natural course, activity and severity of BD is not fully known.

Objectives

the purpose of this research is to describe the clinical spectrum, activity and severity of BD in a group of Colombian patients.

Methods

a longitudinal, observational, descriptive and prospective study was realized in a group of patients with BD, who were evaluated and followed for the rheumatology department at the Hospital Pablo Tobón Uribe, Medellín, Colombia.

Results

20 patients (15 women and 5 men) were found, with an average of 42.1±11.2 years old at diagnosis. The most common clinical manifestations were the oral (95%) and genital (75%) ulcers, followed by cutaneous (60%), ocular (55%), articular (45%), gastrointestinal (40%), vascular (15%) and neurological (15%) involvement. The recurrent oral ulcers were the most common onset manifestation. The mean duration between the onset symptom and the fulfillment of diagnostic criteria was 4.45±4.19 years. 50% patients were classified as having moderate disease and 35% as having severe disease.

Conclusions

BD is an underdiagnosed disease in our environment. The mucocutaneous ulcers represent the main clinical finding and can precede other manifestations for a long time, causing a delay in diagnosis and allowing an aggressive behavior.

Key words:
Behcet's disease
vasculitis
skin manifestations
oral manifestation
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Copyright © 2009. Asociación Colombiana de Reumatología
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