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Inicio Revista Colombiana de Psiquiatría Neutropenia aguda en un paciente con delírium tratado con quetiapina
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Vol. 39. Núm. 2.
Páginas 433-439 (Junio 2010)
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Vol. 39. Núm. 2.
Páginas 433-439 (Junio 2010)
Reporte de caso
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Neutropenia aguda en un paciente con delírium tratado con quetiapina
Acute Neutropenia in a Patient with Delirium Treated with Quetiapine
Visitas
1698
Juan David Velásquez Tirado1,
Autor para correspondencia
jdvelasqueztirado@gmail.com

Correspondencia: Juan David Velásquez Tirado, Facultad de Medicina, Universidad Pontificia Bolivariana, Calle 78B No.72A-109, Medellín, Colombia
, Lina María Escobar Gómez2
1 Médico psiquiatra. Especialista en psiquiatra de enlace. Profesor asociado de la Universidad Pontificia Bolivariana. Grupo de Investigación en Psiquiatría de Enlace (GIPE). Psiquiatra de enlace, Clínica Universitaria Bolivariana. Medellín, Colombia
2 Médica psiquiatra. Hospital Universitario San Vicente de Paúl. Medellín, Colombia
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Resumen
Introducción

La neutropenia es reconocida como un efecto adverso observado con los medicamentos antipsicóticos, principalmente la clozapina. Aunque rara, la administración de quetiapina puede llevar a la aparición de este efecto adverso con altas tasas de morbimortalidad.

Objetivo

Describir un caso de neutropenia asociada con el uso de quetiapina en un paciente con delírium, quien posteriormente con la suspensión del medicamento presenta la resolución del cuadro.

Método

Reporte de caso de un hombre de 38 años de edad.

Resultado y conclusiones

Aun cuando el riesgo de neutropenia asociado con quetiapina es relativamente bajo, es importante la implementación rutinaria de un cuadro hemático tanto al inicio de la administración de quetiapina como de manera periódica. Siempre que sea posible se debe evitar combinar quetiapina con medicamentos con reconocida asociación con neutropenia.

Palabras clave:
quetiapina
neutropenia
efectos adversos
Abstract
Introduction

Neutropenia is a side effect of the use of antipsychotic drugs, mainly clozapine. Although rare, the administration of quetiapine may lead to the development of this adverse effect with high rates of morbidity and mortality.

Objective

To describe a case of neutropenia associated with the use of quetiapine in a patient with delirium and its subsequent resolution when the medication was withdrawn.

Method

Case report.

Results and conclusions

Although the risk of neutropenia associated with the use of quetiapine is relatively low, it is important to implement routine hemograms at the beginning of the treatment with quetiapine, and on a regular basis. Whenever possible, combinations of quetiapine and other drugs with netropenia as a recognized side effect must be avoided.

Key words:
Quetiapine
neutropenia
adverse effects
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Referencias
[1]
Y Skrobik.
Delirium prevention and treatment.
Crit Care Clin, 25 (2009), pp. 585-591
[2]
E Iacobone, J Bailly-Salin, A Polito, D Friedman, RD Stevens, T Sharshar.
Sepsis-associated encephalopathy and its differential diagnosis.
Crit Care Med, 37 (2009), pp. S331-S336
[3]
S Vaishnavi, V Rao, JR Fann.
Neuropsychiatric problems after traumatic brain injury: unraveling the silent epidemic.
Psychosomatics, 50 (2009), pp. 198-205
[4]
R Nakase-Thompson, M Sherer, SA Yablon, TG Nick, PT Trzepacz.
Acute confusion following traumatic brain injury.
Brain Inj, 18 (2004), pp. 131-142
[5]
J Markowitz, M Narasimhan.
Delírium and antipsychotics: a systematic review of epidemiology and somatic treatment options.
Psychiatry (Edgmont), 5 (2008), pp. 29-36
[6]
TL Schwartz, PS Masand.
The role of atypical antipsychotics in the treatment of delírium.
Psychosomatics, 43 (2002), pp. 171-174
[7]
Y Sasaki, T Matsuyama, S Inoue, T Sunami, T Inoue, K Denda, et al.
A prospective, open-label, flexibledose study of quetiapine in the treatment of delírium.
J Clin Psychiatry, 64 (2003), pp. 1316-1321
[8]
KU Lee, WY Won, HK Lee, YS Kweon, CT Lee, CU Pae, et al.
Amisulpride versus quetiapine for the treatment of delírium: a randomized, open prospective study.
Int Clin Psychopharmacol, 20 (2005), pp. 311-314
[9]
CU Pae, SJ Lee, CU Lee, C Lee, IH Paik.
A pilot trial of quetiapine for the treatment of patients with delírium.
Hum Psychopharmacol, 19 (2004), pp. 125-127
[10]
Adverse effects of the atypical antipsychotics.
Collaborative Working Group on Clinical Trial Evaluations.
J Clin Psychiatry, 59 Suppl 12 (1998), pp. 17-22
[11]
R Watts.
Neutropenia.
Wintrobe's Clinical Hematology, 12th Ed., pp. 1527-1547
[12]
Electronic Medicines Compendium [Internet].
Leatherhead: Datapharm Communications SPC. [Internet] 2009 Mar 27 [2009 Oct 28].
[13]
HS Duggal, I Singh.
Psychotropic druginduced neutropenia.
Drugs Today (Barc), 41 (2005), pp. 517-526
[14]
P Croarkin, T Rayner.
Acute neutropenia in a patient treated with quetiapine.
Psychosomatics, 42 (2001), pp. 368
[15]
RS Jackson.
Continuing treatment with novel antipsychotic drugs despite leukopenia or thrombocytopenia.
Arch Gen Psychiatry, 58 (2001), pp. 706-707
[16]
C Cowan, C Oakley.
Leukopenia and neutropenia induced by quetiapine.
Prog Neuropsychopharmacol Biol Psychiatry, 31 (2007), pp. 292-294
[17]
HG Ruhé, HE Becker, P Jessurun, CH Marees, M Heeringa, HD Vermeulen.
Agranulocytosis and granulocytopenia associated with quetiapine.
Acta Psychiatr Scand, 104 (2001), pp. 311-313
[18]
N Clark, E Weissberg, J Noel.
Quetiapine and leukopenia.
Am J Psychiatry, 158 (2001), pp. 817-818
[19]
BR Shankar.
Quetiapine-induced leucopenia and thrombocytopenia.
Psychosomatics, 48 (2007), pp. 530-531
[20]
A Iraqi.
A case report of pancytopenia with quetiapine use.
Am J Geriatr Psychiatry, 11 (2003), pp. 694
[21]
O Oluboka, D Haslam, T Lam, D Bown-De marco.
Quetiapine-induced leucopenia: possible dosage-related ph en omen on.
Can J Psychiatry, 48 (2003), pp. 65-66
[22]
P Nair, S Lippmann.
Is leukopenia associated with divalproex and/or quetiapine?.
Psychosomatics, 46 (2005), pp. 188-189
[23]
A Rahman, LM Mican, C Fischer, AH Campbell.
Evaluating the incidence of leukopenia and neutropenia with valproate, quetiapine, or the combination in children and adolescents.
Ann Pharmacother, 43 (2009), pp. 822-830
[24]
W Aichhorn, J Marksteiner, T Walch, G Zernig, A Saria, G Kemmler.
Influence of age, gender, body weight, and valproate comedication on quetiapine plasma concentrations.
Int Clin Psychopharmacol, 21 (2006), pp. 81-85
[25]
DJ King, CG Link, B Kowalcyk.
A comparison of bd and tid dose regimens of quetiapine (Seroquel) in the treatment of schizophrenia.
Psychopharmacology (Berl), 137 (1998), pp. 139-146

Conflicto de interés: los autores manifiestan que no tienen ningún conflicto de interés en este artículo.

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