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Inicio Revista Colombiana de Cancerología Polimorfismos genéticos de interleucinas IL-1B-511, IL-1RN, IL-10, factor de ne...
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Vol. 15. Núm. 2.
Páginas 85-97 (Enero 2011)
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Vol. 15. Núm. 2.
Páginas 85-97 (Enero 2011)
DOI: 10.1016/S0123-9015(11)70071-3
Acceso a texto completo
Polimorfismos genéticos de interleucinas IL-1B-511, IL-1RN, IL-10, factor de necrosis tumoral α-308 e infección por Helicobacter pylori CagA positivo en cáncer gástrico y úlcera duodenal en diferentes poblaciones en Colombia
Genetic Polymorphisms of IL-1B-511, IL-1RN, IL-10 Interleukins, Tumor Necrosis α-308 and Positive Helicobacter pylori CagA Infection in Gastric Cancer and Duodenal Ulcer in Different Populations in Colombia
Visitas
...
Teresa Martínez1,
Autor para correspondencia
tmartinez@cancer.gov.co

Correspondencia: Teresa Martínez P. Grupo de Investigación Epidemiológica, Instituto Nacional de Cancerología. Av. 1a No. 9-85 Bogotá, Colombia. Teléfono: 5930310, ext. 4206.
, Gustavo Hernández1, María M. Bravo2, Esperanza Trujillo2, Andrés Quiroga2, Juan C. Robayo3, Jesús Pérez4, Juan C. Bravo5, Margarita Camorlinga6
1 Grupo de Investigación Epidemiológica del Cáncer, Instituto Nacional de Cancerología, Bogotá D.C., Colombia
2 Grupo de Biología del Cáncer, Instituto Nacional de Cancerología, Bogotá D.C., Colombia
3 Departamento de Gastroenterología, Fundación Santa Fe, Bogotá D. C., Colombia
4 Grupo de investigación, Clínica General del Norte, Barranquilla, Colombia
5 Departamento de Patología, Fundación Valle del Lili, Cali, Valle, Colombia
6 Hospital de Pediatría CMN Siglo XXI, Instituto Mexicano de Seguros Sociales, Ciudad de México, México
Información del artículo
Resumen
Objetivo

Determinar la asociación entre los polimorfismos IL-1B-511, IL-1RN, TNF-α-308, IL-10-819 e IL-101082 y la infección por Helicobacter pylori CagA positivo en un grupo de pacientes con cáncer gástrico y úlcera duodenal en diferentes poblaciones en Colombia.

Métodos

Estudio de casos y controles con 341 pacientes: con gastritis no atrófica, 194; con cáncer gástrico, 58; úlcera duodenal con lesiones preneoplásicas, 54; y con úlcera duodenal, 35. La genotipificación de los polimorfismos se hizo por discriminación alélica usando PCR en tiempo real, y la del IL-1RN, por PCR convencional y electroforesis en agarosa. La infección por Helicobacter pylori CagA se determinó mediante ELISA. Se utilizó la regresión logística en el análisis estadístico.

Resultados

Ser portador del genotipo IL-1B-511TT (OR=4,69; IC 95% 1,22-18,09) y tener una infección por Helicobacter pylori CagA positivo (OR=4,43; IC 95% 1,72–11,4) se asociaron a cáncer gástrico. Tener una infección por Helicobacter pylori CagA positivo (OR=4,39; IC95% 1,82–10,59) se asoció a la presencia de úlcera duodenal con lesiones preneoplásicas, y ser portador del genotipo IL-1B-511CT se asoció a úlcera duodenal (OR=0,30; IC 95% 0,10–0,91).

Conclusión

Los resultados sugieren que la respuesta pro-inflamatoria y la genética virulenta de la bacteria son factores relacionados con los diferentes desenlaces ocasionados por la infección por Helicobacter pylori en la población estudiada; así, el polimorfismo IL-1B-511 es un factor relacionado con cáncer gástrico y úlcera duodenal, y la infección por Helicobacter pylori CagA positivo es un factor asociado a cáncer gástrico y úlcera duodenal con lesiones preneoplásicas.

Palabras clave:
Interleucinas 1B
10
factor de necrosis tumoral alpha
Helicobacter pylori
proteína cagA
neoplasias de estomago
ulcera duodenal
Abstract
Objective

To determine the association between the IL-1B-511, IL-1RN, TNF-α-308, IL-10-819 and IL-101082 polymorphisms and positive Heliocobacter pylori CagA infection in a group of patients with gastric cancer and duodenal ulcer in different populations in Colombia.

Methods

A case-control study was performed on 341 patients: those with non-atrophic gastritis, 194; with gastric cancer, 58; duodenal ulcer with preneoplastic lesion, 54; and with duodenal ulcer, 35. The genotyping of polymorphisms was done with allelic discrimination using PCR in real time, and that for IL-1RN with conventional PCR and agarose electrophoresis. Helicobacter pylori CagA infection was ascertained with ELISA. Logistic regression was used in statistical analysis.

Results

Being a carrier of genotype IL-1B-511TT (OR=4.69; CI 95% 1.22–18.09) and being positive for Helicobacter pylori CagA infection (OR=4.43; CI 95% 1.72–11.4) are associated with gastric cancer. Positive Helicobacter pylori CagA infection (OR=4.39; CI 95% 1.82–10.59) is associated with the presence of duodenal ulcer with preneoplastic lesions, being a carrier of genotype IL-1B-511CT is associated with duodenal ulcer (OR=0.30; CI 95% 0.10–0.91).

Conclusion

The results suggest that pro-inflammatory response and virulent bacterial genetics are factors related to the different outcomes brought about by Helicobacter pylori infection in the population studied; that is, the IL-1B-511 polymorphism is a factor related to gastric cancer and duodenal ulcer, and positive Helicobacter pylori CagA infection is a factor associated with gastric cancer and duodenal ulcer with preneoplastic lesions.

Key words:
Interleukins 1B
10
tumor necrosis factor-alpha
Helicobacter pylori
cagA protein
stomach neoplasm
duodenal ulcer
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