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Inmunodetección de metaloproteinasas de matriz extracelular (MMPs)-2, -9, -13 y -14 en lesiones apicales asociadas con periodontitis apical asintomática
Immunodetection of matrix metalloproteinases (MMPs)-2, -9, -13 and -14 in periapical lesions associated with asymptomatic apical periodontitis
V. Mundi Burgos1,5, A. Dezerega Piwonka2,5, C. Osorio Alfaro1,5, N. Dutzan Muñoz3,5, M.E. Franco Martínez4, A.V. Ortega Pinto4, M. Hernández Ríos4,5,
Autor para correspondencia
mhernandezrios@gmail.com

Correspondencia autor: Laboratorio de Biología Periodontal, Departamento de Odontología Conservadora, Facultad de Odontología, Universidad de Chile. Chile.
1 Programa de Magíster en Ciencias Odontológicas. Facultad de Odontología, Universidad de Chile. Chile
2 Área de Endodoncia, Departamento de Odontología Conservadora. Facultad de Odontología, Universidad de Chile. Chile
3 Área de Periodoncia, Departamento de Odontología Conservadora. Facultad de Odontología, Universidad de Chile. Chile
4 Área de Patología, Departamento de Patología. Facultad de Odontología, Universidad de Chile. Chile
5 Laboratorio de Biología Periodontal. Facultad de Odontología, Universidad de Chile. Chile
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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La periodontitis apical asintom&#225;tica &#40;PAa&#41; es una patolog&#237;a infecciosa caracterizada por destrucci&#243;n &#243;sea perirradicular asociada a un proceso inflamatorio cr&#243;nico y producci&#243;n de mediadores inflamatorios&#44; entre los cuales se encuentran las metaloproteinasas de matriz extracelular &#40;MMPs&#41;&#46; Entre &#233;stas&#44; las MMPs-13&#44; -14&#44; -2 y -9&#44; son producidas por el tejido &#243;seo y degradan sin&#233;rgicamente el col&#225;geno tipo I&#44; principal componente de los tejidos periodontales&#44; y gelatina&#44; producto de la degradaci&#243;n y desnaturaci&#243;n del col&#225;geno&#46; El objetivo de este estudio fue determinar el patr&#243;n de expresi&#243;n de las MMPs-2&#44; -9&#44; -13 y -14 en granulomas periapicales &#40;GPAs&#41;&#44; quistes radiculares inflamatorios &#40;QRIs&#41; y ligamento periodontal sano &#40;LS&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0010">Materiales y M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se seleccionaron 12 pacientes con diagn&#243;stico cl&#237;nico de PAa e indicaci&#243;n de exodoncia a partir de los cuales se obtuvieron biopsias de lesiones periapicales &#40;LPAs&#41;&#46; Como controles&#44; se seleccionaron 7 individuos con indicaci&#243;n de exodoncia de premolares por ortodoncia&#44; obteni&#233;ndose biopsias de LS&#46; Se efectu&#243; el diagn&#243;stico an&#225;tomo-patol&#243;gico de los espec&#237;menes y se caracteriz&#243; la expresi&#243;n de las MMPs en estudio mediante inmunohistoqu&#237;mica&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Las MMPs en estudio s&#243;lo se detectaron en GPAs y QRIs&#44; y se inmunolocalizaron principalmente en el infiltrado inflamatorio de &#233;stos&#46; Adicionalmente&#44; la MMP-2 se identific&#243; en fibroblastos del tejido conectivo&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">MMPs-2&#44; -9&#44; -13 y -14 se expresan predominantemente en el infiltrado inflamatorio de las LPAs y no en LS&#44; y por tanto se sugiere la participaci&#243;n de estos mediadores en la patog&#233;nesis de la PAa&#46;</p>"
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        "resumen" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Asymptomatic apical periodontitis &#40;aAP&#41; is an infectious disease characterized by perirradicular bone destruction associated with chronic inflammation and release of inflammatory mediators&#44; such as matrix metalloproteinases &#40;MMPs&#41;&#46; MMPs-13&#44; -14 and -2&#44; -9 are bone-expressed enzymes that can synergistically degrade collagen I&#44; the main component of periodontal extracellular matrix&#44; and gelatin&#44; the product of degradation and denaturation of collagen&#46; The aim of this study was to characterize the expression pattern of MMPs-2&#44; -9&#44; -13&#44; and -14 in periapical granulomas &#40;PGs&#41;&#44; radicular cysts &#40;RCs&#41; and healthy periodontal ligament &#40;PDL&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0030">Materials and Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Individuals with clinical diagnosis of aAP and indication of extraction were selected &#40;N&#61;12&#41;&#44; and biopsies of periapical lesions &#40;PLs&#41; were obtained&#46; For controls&#44; 7 subjects with indication of premolar extraction for orthodontic reasons were selected&#44; and PDL biopsies were obtained&#46; Samples were diagnosed by anatomopathological examination and immunohistochemical staining was carried out to characterize MMPs expression&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0035">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">MMPs-2&#44; -9&#44; -13 and -14 detection was limited to PLs and were localized mainly to inflammatory infiltrate on both&#44; PGs and RCs&#46; Additionally&#44; MMP-2 was immunolocalized to fibroblasts from the connective tissue&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0040">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Whereas MMPs-2&#44; -9&#44; -13 and -14 were not detected in healthy periodontal ligament&#44; they were highly expressed on inflammatory infiltrate from PGs and RCs&#44; suggesting a role of these mediators in aAP pathogenesis&#46;</p>"
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