Correspondencia autor: Laboratorio de Biología Periodontal, Departamento de Odontología Conservadora, Facultad de Odontología, Universidad de Chile. Chile.
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Chile" "etiqueta" => "3" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Área de Patología, Departamento de Patología. Facultad de Odontología, Universidad de Chile. Chile" "etiqueta" => "4" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Laboratorio de Biología Periodontal. Facultad de Odontología, Universidad de Chile. Chile" "etiqueta" => "5" "identificador" => "aff0025" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia autor: Laboratorio de Biología Periodontal, Departamento de Odontología Conservadora, Facultad de Odontología, Universidad de Chile. Chile." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Immunodetection of matrix metalloproteinases (MMPs)-2, -9, -13 and -14 in periapical lesions associated with asymptomatic apical periodontitis" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2011-01-18" "fechaAceptado" => "2011-03-11" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec336295" "palabras" => array:3 [ 0 => "Periodontitis apical asintomática" 1 => "lesiones periapicales" 2 => "metaloproteinasas de matriz extracelular" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec336296" "palabras" => array:3 [ 0 => "Asymptomatic apical periodontitis" 1 => "periapical lesions" 2 => "extracellular matrix metalloproteinases" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La periodontitis apical asintomática (PAa) es una patología infecciosa caracterizada por destrucción ósea perirradicular asociada a un proceso inflamatorio crónico y producción de mediadores inflamatorios, entre los cuales se encuentran las metaloproteinasas de matriz extracelular (MMPs). Entre éstas, las MMPs-13, -14, -2 y -9, son producidas por el tejido óseo y degradan sinérgicamente el colágeno tipo I, principal componente de los tejidos periodontales, y gelatina, producto de la degradación y desnaturación del colágeno. El objetivo de este estudio fue determinar el patrón de expresión de las MMPs-2, -9, -13 y -14 en granulomas periapicales (GPAs), quistes radiculares inflamatorios (QRIs) y ligamento periodontal sano (LS).</p> <span class="elsevierStyleSectionTitle" id="sect0010">Materiales y Métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se seleccionaron 12 pacientes con diagnóstico clínico de PAa e indicación de exodoncia a partir de los cuales se obtuvieron biopsias de lesiones periapicales (LPAs). Como controles, se seleccionaron 7 individuos con indicación de exodoncia de premolares por ortodoncia, obteniéndose biopsias de LS. Se efectuó el diagnóstico anátomo-patológico de los especímenes y se caracterizó la expresión de las MMPs en estudio mediante inmunohistoquímica.</p> <span class="elsevierStyleSectionTitle" id="sect0015">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Las MMPs en estudio sólo se detectaron en GPAs y QRIs, y se inmunolocalizaron principalmente en el infiltrado inflamatorio de éstos. Adicionalmente, la MMP-2 se identificó en fibroblastos del tejido conectivo.</p> <span class="elsevierStyleSectionTitle" id="sect0020">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">MMPs-2, -9, -13 y -14 se expresan predominantemente en el infiltrado inflamatorio de las LPAs y no en LS, y por tanto se sugiere la participación de estos mediadores en la patogénesis de la PAa.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Asymptomatic apical periodontitis (aAP) is an infectious disease characterized by perirradicular bone destruction associated with chronic inflammation and release of inflammatory mediators, such as matrix metalloproteinases (MMPs). MMPs-13, -14 and -2, -9 are bone-expressed enzymes that can synergistically degrade collagen I, the main component of periodontal extracellular matrix, and gelatin, the product of degradation and denaturation of collagen. The aim of this study was to characterize the expression pattern of MMPs-2, -9, -13, and -14 in periapical granulomas (PGs), radicular cysts (RCs) and healthy periodontal ligament (PDL).</p> <span class="elsevierStyleSectionTitle" id="sect0030">Materials and Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Individuals with clinical diagnosis of aAP and indication of extraction were selected (N=12), and biopsies of periapical lesions (PLs) were obtained. For controls, 7 subjects with indication of premolar extraction for orthodontic reasons were selected, and PDL biopsies were obtained. Samples were diagnosed by anatomopathological examination and immunohistochemical staining was carried out to characterize MMPs expression.</p> <span class="elsevierStyleSectionTitle" id="sect0035">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">MMPs-2, -9, -13 and -14 detection was limited to PLs and were localized mainly to inflammatory infiltrate on both, PGs and RCs. Additionally, MMP-2 was immunolocalized to fibroblasts from the connective tissue.</p> <span class="elsevierStyleSectionTitle" id="sect0040">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Whereas MMPs-2, -9, -13 and -14 were not detected in healthy periodontal ligament, they were highly expressed on inflammatory infiltrate from PGs and RCs, suggesting a role of these mediators in aAP pathogenesis.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:50 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "AAE Consensus Conference on Diagnostic Terminology: background and perspectives" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G.N. 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año/Mes | Html | Total | |
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2024 Octubre | 4 | 13 | 17 |
2024 Septiembre | 23 | 29 | 52 |
2024 Agosto | 9 | 21 | 30 |
2024 Julio | 7 | 10 | 17 |
2024 Junio | 3 | 6 | 9 |
2024 Mayo | 5 | 6 | 11 |
2024 Abril | 9 | 6 | 15 |
2024 Marzo | 5 | 17 | 22 |
2024 Febrero | 5 | 10 | 15 |
2024 Enero | 16 | 11 | 27 |
2023 Diciembre | 10 | 13 | 23 |
2023 Noviembre | 17 | 11 | 28 |
2023 Octubre | 8 | 16 | 24 |
2023 Septiembre | 6 | 6 | 12 |
2023 Agosto | 6 | 18 | 24 |
2023 Julio | 8 | 19 | 27 |
2023 Junio | 13 | 25 | 38 |
2023 Mayo | 36 | 7 | 43 |
2023 Abril | 41 | 3 | 44 |
2023 Marzo | 26 | 4 | 30 |
2023 Febrero | 20 | 3 | 23 |
2023 Enero | 5 | 6 | 11 |
2022 Diciembre | 6 | 8 | 14 |
2022 Noviembre | 19 | 9 | 28 |
2022 Octubre | 101 | 8 | 109 |
2022 Septiembre | 33 | 11 | 44 |
2022 Agosto | 43 | 8 | 51 |
2022 Julio | 8 | 5 | 13 |
2022 Junio | 7 | 6 | 13 |
2022 Mayo | 8 | 6 | 14 |
2022 Abril | 16 | 13 | 29 |
2022 Marzo | 14 | 13 | 27 |
2022 Febrero | 4 | 7 | 11 |
2022 Enero | 8 | 7 | 15 |
2021 Diciembre | 9 | 8 | 17 |
2021 Noviembre | 4 | 4 | 8 |
2021 Octubre | 7 | 8 | 15 |
2021 Septiembre | 7 | 12 | 19 |
2021 Agosto | 6 | 3 | 9 |
2021 Julio | 4 | 5 | 9 |
2021 Junio | 5 | 7 | 12 |
2021 Mayo | 8 | 7 | 15 |
2021 Abril | 40 | 29 | 69 |
2021 Marzo | 17 | 3 | 20 |
2021 Febrero | 10 | 8 | 18 |
2021 Enero | 6 | 9 | 15 |
2020 Diciembre | 5 | 8 | 13 |
2020 Noviembre | 5 | 6 | 11 |
2020 Octubre | 6 | 1 | 7 |
2020 Septiembre | 3 | 1 | 4 |
2020 Agosto | 5 | 2 | 7 |
2020 Julio | 4 | 3 | 7 |
2020 Junio | 3 | 9 | 12 |
2020 Mayo | 4 | 3 | 7 |
2020 Abril | 3 | 4 | 7 |
2020 Marzo | 3 | 0 | 3 |
2020 Febrero | 4 | 2 | 6 |
2020 Enero | 2 | 5 | 7 |
2019 Diciembre | 8 | 7 | 15 |
2019 Noviembre | 2 | 1 | 3 |
2019 Octubre | 2 | 2 | 4 |
2019 Septiembre | 3 | 0 | 3 |
2019 Agosto | 1 | 2 | 3 |
2019 Julio | 7 | 6 | 13 |
2019 Junio | 16 | 11 | 27 |
2019 Mayo | 50 | 7 | 57 |
2019 Abril | 24 | 8 | 32 |
2019 Marzo | 3 | 5 | 8 |
2019 Febrero | 1 | 3 | 4 |
2019 Enero | 2 | 1 | 3 |
2018 Diciembre | 4 | 7 | 11 |
2018 Noviembre | 4 | 6 | 10 |
2018 Octubre | 6 | 20 | 26 |
2018 Septiembre | 2 | 9 | 11 |
2018 Agosto | 3 | 6 | 9 |
2018 Julio | 1 | 5 | 6 |
2018 Junio | 2 | 7 | 9 |
2018 Mayo | 4 | 10 | 14 |
2018 Abril | 0 | 3 | 3 |
2018 Marzo | 1 | 2 | 3 |
2018 Febrero | 5 | 3 | 8 |
2018 Enero | 1 | 0 | 1 |
2017 Diciembre | 2 | 0 | 2 |
2017 Noviembre | 2 | 1 | 3 |
2017 Octubre | 3 | 2 | 5 |
2017 Septiembre | 7 | 4 | 11 |
2017 Agosto | 4 | 2 | 6 |
2017 Julio | 9 | 5 | 14 |
2017 Junio | 10 | 12 | 22 |
2017 Mayo | 3 | 5 | 8 |
2017 Abril | 6 | 8 | 14 |
2017 Marzo | 3 | 37 | 40 |
2017 Febrero | 6 | 7 | 13 |
2017 Enero | 4 | 0 | 4 |
2016 Diciembre | 9 | 3 | 12 |
2016 Noviembre | 17 | 4 | 21 |
2016 Octubre | 17 | 8 | 25 |
2016 Septiembre | 14 | 2 | 16 |
2016 Agosto | 10 | 0 | 10 |
2016 Julio | 7 | 2 | 9 |
2016 Junio | 6 | 2 | 8 |
2016 Mayo | 12 | 11 | 23 |
2016 Abril | 24 | 6 | 30 |
2016 Marzo | 12 | 13 | 25 |
2016 Febrero | 5 | 9 | 14 |
2016 Enero | 5 | 8 | 13 |
2015 Diciembre | 5 | 13 | 18 |
2015 Noviembre | 6 | 7 | 13 |
2015 Octubre | 10 | 13 | 23 |
2015 Septiembre | 3 | 6 | 9 |
2015 Agosto | 5 | 1 | 6 |
2015 Julio | 6 | 3 | 9 |
2015 Junio | 2 | 0 | 2 |
2015 Mayo | 0 | 1 | 1 |
2015 Abril | 4 | 6 | 10 |
2015 Marzo | 2 | 1 | 3 |
2015 Febrero | 4 | 1 | 5 |
2015 Enero | 6 | 2 | 8 |
2014 Diciembre | 3 | 2 | 5 |
2014 Noviembre | 2 | 1 | 3 |
2014 Octubre | 1 | 0 | 1 |