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Vol. 46. Núm. 6.
Páginas 245-249 (Enero 2003)
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Vol. 46. Núm. 6.
Páginas 245-249 (Enero 2003)
Acceso a texto completo
Estudio de la inestabilidad microsatélite en tumores borderline y carcinoma de ovario
Microsatellite instability in borderline tumors and ovarian carcinoma
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4147
M. Vidaurretaa, I. Almansaa, M.T. Sanza, F. Tresserrab, L. Lópezb, M.L. Maestroa,
Autor para correspondencia
mmaestro@hcsc.es

Correspondencia: Servicio Análisis Clínicos. Hospital Clínico San Carlos. Martín Lagos, s/n. 28040 Madrid. España
, S. Dexeusa
a Sección de Biología Tumoral. Servicio de Análisis Clínicos. Hospital Clínico San Carlos. Madrid. España
b Servicio de Ginecología y Obstetricia. Fundación Santiago Dexeus Font. Barcelona. España
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Resumen

El objetivo de nuestro estudio es determinar la inestabilidad de tres microsatélites (BAT25, BAT26 y NME1) y observar si está implicada en el desarrollo de los tumores esporádicos de ovario. El trabajo se ha llevado a cabo en 40 pacientes intervenidas quirúrgicamente por tumor de ovario esporádico. La comprobación de la inestabilidad se realizó por comparación del tejido sano y tumoral de cada una de las pacientes. Sólo se encontró inestabilidad en 3 casos: en BAT26 en tumor borderline; en BAT25 en cistoadenocarcinoma de células claras, y en NME1 en cistoadenocarcinoma papilar seroso en diferentes pacientes. La inestabilidad microsatélite no parece estar implicada en la aparición o el desarrollo de los tumores esporádicos de ovario

Palabras clave:
Inestabilidad
Microsatélite
Ovario
Borderline
Carcinoma
Summary

The aim of our study is instability's determination of three microsatellite (BAT25, BAT26 and NME1) and see if they are implicating in development of sporadic ovarian tumours. This study have been carrying out in 40 patients operated for sporadic ovarian tumour. The instability comprobation was realized for comparation between healthy tissue and tumour tissue of each patient. Was only found instability in 3 cases: in BAT26 in borderline tumour, in BAT25 in clear cells cystadenoma and instability in NME1 in papilar serous cystadenoma in diferents patients. The conclusion of this study is that microsatellite instability does not seem be implicated in apparition or development of sporadic ovarian tumours

Keywords:
Instability
Microsatellite
Ovarian
Borderline
Carcinoma
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Bibliografía
[1.]
A. Phyllis, T. Tony, B. Sherry.
Cancer statistics. CA.
Cancer J Clin, 45 (1995), pp. 8-30
[2.]
M.S. Piver, T.R. Baker, M. Peidmonte, A.M. Sandecki.
Epidemiology and etiology of ovarian cancer.
Semin Oncol, 18 (1991), pp. 177-185
[3.]
R.E. Scully.
Ovarian tumors. A review.
Am J Pathol, 87 (1997), pp. 686
[4.]
R.E. Scully, S.F. Seon, L.H. Sobin.
Histologycal typing of ovarian tumors, World Health Organization, (1973),
[5.]
X. Matias-Guin, J. Prat.
Molecular pathology of ovarian carcinomas.
Virchows Arch, 433 (1998), pp. 103-111
[6.]
J. Prat, M. De Nictolis.
Serous borderline tumors of the ovary: a long-term follow-up study of 137 cases including 18 with a micropapillary pattern and 20 with microinvasion.
Am J Surg Pathol, 26 (2002), pp. 1111-1128
[7.]
P. Rusell.
Borderline tumors of the ovary: a conceptual dilema.
Clin Obstet Gynaecol, 11 (1984), pp. 254
[8.]
H.S. Gallager.
Pronostic importance of histologyc type in ovarian carcinoma.
Natl Cancer Inst Monogr, 42 (1975), pp. 13-14
[9.]
T.G. Day, H.S. Gallager, F.N. Rutledge.
Epithelial carcinoma of the ovary: pronostic importance of histologic grade.
Cancer Inst Monogr, 42 (1975), pp. 15-18
[10.]
J. Redman, G. Petroni, P.E. Scrigo, N.L. Geller, T.B. Hakes.
Pronostic factors in advanced ovarian carcinoma.
J Clin Oncol, 4 (1986), pp. 515-523
[11.]
C. Moss, S. Kaye.
Ovarian Cancer progress and continuing controversies in management.
Eur J Cancer, 38 (2002), pp. 1205-1211
[12.]
J. Van Houwelingen, W. Ten Bokkel Huinink, M. Van der Burg, A.T. Van Oosterom, J.P. Neijt.
Predictability of the survival of patient with advanced ovarian cancer.
J Clin Oncol, 7 (1989), pp. 769-773
[13.]
M.L. Friedlander, A.J. Dembo.
Prognostic factors in ovarian cancer.
Semin Oncol, 18 (1991), pp. 205-212
[14.]
M. Montella, M.R. De Marco, F. Romeo, R. Ventura.
Survival in ovarian cancers treated at National Cancer Institute in Naples Italy 1985-1990.
Eur J Gynaecol Oncol, 14 (1993), pp. 249-254
[15.]
J. Mendelsohn, P.M. Howlei, M.A. Israel, L.A. Liotta.
The molecular basis of cancer, WB Saunders, (1995),
[16.]
C.R. Boland, S.N. Thibodeau, S.R. Hamilton, D. Sidransky, J.R. Eshleman, R.W. Burt, et al.
A national cancer institute workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer.
Cancer Res, 58 (1998), pp. 248-257
[17.]
A.K. Sood, R. Holmes, M.J.C. Hendrix, R.E. Buller.
Application of the National Cancer Institute Criteria for Determination of Microsatellite Instability in Ovarian Cancer.
Cancer Res, 61 (2001), pp. 4371-4374
[18.]
R.E. Scully, R.H. Young, P.B. Clement.
Atlas of tumor pathology. Tumors of the ovary, maldeveloped gonads, fallopian tube and broad ligament, Armed Forces Institute of Pathology, (1998),
[19.]
L.H. Sobin, C.H. Wittekind.
TNM classification of malignant tumors, Wiley-Liss, (2002),
[20.]
B.L. King, M.L. Carcangiu, D. Carter, M. Kiechel, J. Pfisterer, A. Pfleiderer, et al.
Microsatellite instability in ovarian neoplasms.
Br J Cancer, 72 (1995), pp. 376-382
[21.]
Y.C. Shih, J. Kerr, T.G. Hurst, S.K. Khoo, B.G. Ward, G. Chenevix-Trench.
No evidence for microsatellite instability from allelotype analysis of benign and low malignant potential ovarian neoplasms.
Gynecol Oncol, 69 (1998), pp. 210-213
[22.]
A.M. Codegoni, F. Bertoni, G. Colella, G. Caspani, L. Grassi, M. D'Incalci, et al.
Microsatellite instability and frameshift mutations in genes involved in cell cycle progression or apoptosis in ovarian cancer.
Oncol Res, 11 (1999), pp. 297-301
[23.]
H. Iwabuchi, M. Sakamoto, H. Sakunaga, Y.Y. Ma, M.L. Carcangiu, D. Pinkel, et al.
Genetic analysis of benign, low-grade, and high-grade ovarian tumors.
Cancer Res, 15 (1995), pp. 6172-6180
[24.]
J. Tangir, N.S. Loughredge, R.S. Berkowitz, M.G. Muto, D.A. Bell, W.R. Welch, et al.
Frequent microsatellite instability in epithelial borderline ovarian tumors.
Cancer Res, 56 (1996), pp. 2501-2505
Copyright © 2003. Sociedad Española de Ginecología y Obstetricia
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