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Transthyretin amyloidosis

Editado por Dr. Juan González Moreno - Hospital Universitario, Spain. Dra. Inés Losada López - Hospital Universitario, Spain

The Special Issue on ATTR amyloidosis aims to provide an updated vision of a disease with two main forms, a hereditary one (ATTRv) and acquired one (ATTRwt). Even if the first one is considered a rare disease, in Spain there are two endemic foci (Valverde del Camino, in Huelva, and Mallorca in the Balearic Islands), that currently represent the 5th major worldwide focus in patient density for this illness. The mutation with the highest prevalence is the Val50Met, which is also the mutation present in the Spanish foci. Despite this being a multisystemic disease, it will usually appear as a very aggressive polyneuropathy. The prevalence of the acquired form ATTRwt, is rising and it is estimated that up to the 13% of the patients with heart failure with preserved ejection fraction admitted in Spanish hospitals might have this cardiac storage disease. This pathology-focused special issue is relevant due to the recent advances in the diagnosis and treatment of this disease.
Incidence and causes of hospitalization in patients with transthyretin (ATTR-CA) and light chain (AL-CA) cardiac amyloidosis
Daniel Enríquez-Vázquez, Carlos Gómez-Martín, Gonzalo Barge-Caballero, Eduardo Barge-Caballero, Manuel López-Pérez, Raquel Bilbao-Quesada, Eva González-Babarro, Inés Gómez-Otero, ... María G. Crespo-Leiro
Med Clin. 2024;162:e1-e7
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