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Inicio Medicina Clínica (English Edition) Incidence of non-melanoma skin cancer in patients treated with psoralen and ultr...
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Vol. 152. Issue 12.
Pages 488-492 (June 2019)
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Vol. 152. Issue 12.
Pages 488-492 (June 2019)
Original article
Incidence of non-melanoma skin cancer in patients treated with psoralen and ultraviolet A therapy
Incidencia de cáncer cutáneo distinto del melanoma en pacientes tratados con PUVA oral
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José María Ortiz Salvadora,
Corresponding author
josema.ortiz.salvador@gmail.com

Corresponding author.
, Amparo Pérez-Ferriolsa,b, Víctor Alegre de Miquela,b, Martina Saneleuterio Temporalc, Juan José Vilata Corella,b
a Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, Spain
b Facultad de Medicina, Universitat de València, Valencia, Spain
c Hospital Universitario y Politécnico La Fe, Valencia, Spain
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Table 1. Crude incidence rate and adjusted age density of NMSC in the population treated with PUVA therapy.
Abstract
Introduction

Studies reporting incidences of non-melanoma skin cancer (NMSC) are heterogeneous, depend on the geographic area of the studied population and are often short-term. The aim of this study is to determine the incidence of NMSC in patients treated with oral PUVA therapy in the Mediterranean area.

Material and methods

A retrospective, observational study was carried out with a sample of 234 patients treated with systemic PUVA between 1982 and 1996, carrying out a historical follow-up until May 2017. The incidence density rate of CCNM (crude and adjusted) was calculated by direct standardisation. The incidence of CCNM was compared with that reported in the general population in a similar geographical area.

Results

50 neoplasms were diagnosed in 22 patients. The prevalence of CCNM in patients treated with phototherapy was 10.3%. The mean follow-up time was 21 years. The crude-adjusted incidence density rate of CCNM was 554.4–183.9 cases/100,000 treated patients per year. The crude-adjusted incidence density rate of basal cell carcinoma was 352.3–111.2 cases/100.000 patients and of squamous cell carcinoma was 229–77.7 cases/100,000 patients.

Conclusion

PUVA therapy is associated with an increased risk of CCNM in the Mediterranean population.

Keywords:
PUVA therapy
Phototherapy
Skin cancer
Basal cell carcinoma
Squamous cell carcinoma
Carcinoma
Resumen
Introducción

Los trabajos que determinan la incidencia de cáncer cutáneo no melanoma (CCNM) en la población tratada con psoralenos orales+UVA son heterogéneos, dependen de la localización geográfica de la población estudiada y tienen períodos de seguimiento cortos. El objetivo del trabajo es determinar la seguridad a largo plazo de la PUVAterapia y en concreto determinar la incidencia de CCNM en los pacientes tratados con PUVAterapia oral en el área mediterránea.

Material y método

Se ha realizado un estudio longitudinal de seguimiento retrospectivo, recogiendo 234 pacientes tratados con PUVA sistémico entre 1982 y 1996 con un seguimiento hasta mayo de 2017. Se ha calculado la densidad de incidencia de CCNM bruta y ajustada por edad mediante estandarización directa.

Resultados

En 22 pacientes se diagnosticaron 50 neoplasias. La prevalencia de CCNM en pacientes tratados con fototerapia fue del 10,3%. El tiempo medio de seguimiento fue de 21 años. la densidad de incidencia bruta-ajustada de CCNM fue de 554,4-183,9 casos/100.000 pacientes tratados-año. La densidad de incidencia bruta-ajustada de carcinoma basocelular fue de 352,3-111,2 casos/100.000 pacientes y la de carcinoma epidermoide de 229-77,7 casos/100.000 pacientes.

Conclusión

La incidencia de cáncer cutáneo en los pacientes tratados con PUVAterapia es superior a la descrita en la población mediterránea.

Palabras clave:
PUVAterapia
Fototerapia
Cáncer de piel
Carcinoma basocelular
Carcinoma epidermoide
Carcinoma

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