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Inicio Medicina Clínica (English Edition) Human papilloma virus dermatosis in human immunodeficiency virus-positive patien...
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Vol. 148. Issue 9.
Pages 401-404 (May 2017)
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Vol. 148. Issue 9.
Pages 401-404 (May 2017)
Brief report
Human papilloma virus dermatosis in human immunodeficiency virus-positive patients: A 14-year retrospective study in 965 patients
Dermatosis por virus de papiloma humano (VPH) en pacientes infectados por el virus de la inmunodeficiencia humana (VIH): estudio retrospectivo de 965 pacientes durante 14 años
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Almudena Nuno-Gonzaleza,b,
Corresponding author
almudenanuno@hotmail.com

Corresponding author.
, Juan Emilio Losa Garciaa,c, José Luis López Estebaranza,d, María Dolores Martin-Riosa,e
a Universidad Rey Juan Carlos, Madrid, Spain
b Servicio de Dermatología, Hospital Universitario La Paz, Madrid, Spain
c Unidad de Infecciosas, Servicio de Medicina Interna, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, Spain
d Unidad de Dermatología, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, Spain
e Servicio de Medicina Preventiva, Hospital Universitario Rey Juan Carlos, Móstoles, Madrid, Spain
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Figures (1)
Tables (2)
Table 1. Most frequent dermatoses in patients with HIV infection in our study and percentage with regard to total dermatoses in our study (n=595).
Table 2. Comparison between condylomatas and warts: socio-demographic characteristics of HIV-infected patients who present them and CD4 count.
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Abstract
Introduction

The incidence of the human papilloma virus (HPV) has not dropped in HIV-positive patients despite the discovery of antiretroviral therapy (ART). Our goal is to assess the prevalence of HPV in HIV patients and its relationship with the epidemiological and virological characteristics of HIV patients.

Patients and methods

Retrospective cohort of 965 patients diagnosed with HIV from 1998 to 2012. We analysed patients’ demographic factors and factors related to the HPV.

Results

Of the 965 patients examined, 333 consulted a dermatologist. Of these, 52 patients had genital warts (15.6%), 43 had common warts (12.9%) and 8% had both conditions. In total, 28.5% of patients had a skin lesion caused by HPV.

Discussion and conclusion

This is the first longitudinal observational study carried out on HIV-positive patients in the era of ART in which HPV infection is the most common skin pathology. We observed a similar trend in countries with access to ART. This study spreads awareness on the importance of preventing HPV and the difficulty of treating it in HIV-positive patients.

Keywords:
HIV
HPV
Warts
Genital warts
Squamous cell carcinoma
Antiretroviral therapy
Resumen
Introducción

El virus del papiloma humano (VPH) no ha disminuido su incidencia en pacientes infectados por el VIH pese al tratamiento antirretroviral (TAR). Nuestro objetivo es evaluar la prevalencia de VPH en pacientes con VIH y su relación con las características epidemiológicas e inmunovirológicas de los pacientes con VIH.

Pacientes y métodos

Cohorte retrospectiva de 965 pacientes diagnosticados de VIH desde 1998 hasta 2012. En ella analizamos factores demográficos de los pacientes y factores relacionados con el VPH.

Resultados

De los 965 pacientes, 333 consultaron al dermatólogo. De estos, 52 pacientes presentaron condilomas (15,6%) y 43, verrugas 43 (12,9%). Un 8% tuvieron ambas afecciones. En total, un 28,5% de los pacientes tuvieron alguna lesión cutánea causada por VPH.

Discusión y conclusión

Este es el primer estudio observacional longitudinal en pacientes infectados por el VIH en la era del TAR en el que la infección por VPH es la dermatosis más frecuente. Observamos una tendencia similar en los países con acceso a TAR. Este estudio nos alerta sobre la importancia de prevenir y la dificultad de tratar el VPH en los pacientes infectados por el VIH.

Palabras clave:
VIH
VPH
Verrugas
Condilomas
Carcinoma epidermoide
Tratamiento antirretroviral

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