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Vol. 149. Issue 5.
Pages 203-208 (September 2017)
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Vol. 149. Issue 5.
Pages 203-208 (September 2017)
Original article
Association between current smoking and cognitive impairment depends on age: A cross-sectional study in Xi’an, China
Asociación entre el tabaquismo actual y el deterioro cognitivo y su relación con la edad: estudio transversal realizado en Xi’an (China)
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Jie Liu, Suhang Shang, Pei Li, Meiying Deng, Chen Chen, Yu Jiang, Liangjun Dang, Qiumin Qu
Corresponding author
quqiumin@medmail.com.cn

Corresponding author.
Department of Neurology, First Affiliated Hospital of Xi’an, Jiao Tong University, Xi’an, China
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Table 1. Demographic data and clinical characteristics of the study population.
Table 2. Differences in covariates between the cognitive impairment group and the normal cognition group.
Table 3. Relationship between current smoking and cognitive impairment.
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Abstract
Background

Cigarette smoking is a modifiable risk factor for cognitive impairment, while the relationship between current smoking and cognitive impairment is not fully understood. The objectives were to identify a possible association between current smoking and cognitive impairment depending on age in the Chinese rural population.

Methods

Data for the study consisted of 1782 participants (40 years and older) who lived in a rural village in the vicinity of Xi’an, China. Data about smoking history and cognitive function were collected. Cognitive function was scored by the Mini-Mental State Examination. The effect of age on the relationship between current smoking and cognitive impairment was analyzed with interaction and stratified analysis by logistic regression models.

Results

Interaction analysis showed that current smoking is positively related with cognitive impairment (odds ratio [OR]=9.067; 95% confidence interval [95% CI] 1.305–62.979; P=0.026). However, the interaction term, age by current smoking, is negatively related with cognitive impairment (OR=0.969; 95%CI 0.939–0.999; P=0.045). Stratified logistic regression showed that in the 40–65 years of age sublayer, OR of current smoking is 1.966 (P=0.044), whereas in the >65 years of age sublayer, the OR is 0.470 (P=0.130). This means that the association between current smoking and cognitive impairment with age might be positive (OR>1) in lower age sublayers, but no significant difference in higher age sublayers.

Conclusions

In conclusion, current smoking might be positively associated with cognitive impairment in the middle-aged but the relationship declines with increasing age.

Keywords:
Current smoking
Cognitive impairment
Age
Cross-sectional study
Resumen
Antecedentes

El consumo de tabaco es un factor de riesgo modificable para el deterioro cognitivo, no entendiéndose plenamente la relación entre dichas situaciones. El objetivo de este trabajo fue identificar la posible asociación entre el consumo actual de tabaco y el deterioro cognitivo, dependiendo de la edad, en la población rural de China.

Métodos

El estudio incluyó a 1.782 participantes (de 40 años de edad o más) que vivían en un pueblo rural de las cercanías de Xi’an (China). Se recogieron datos acerca del historial de consumo de tabaco y la función cognitiva. La función cognitiva se puntuó mediante la escala Mini-Mental State Examination. El efecto de la edad en la relación entre el consumo de tabaco actual y el deterioro cognitivo se analizó mediante análisis de interacción y estratificación, utilizando modelos de regresión logística.

Resultados

El análisis de interacción reflejó que el consumo de tabaco actual guarda una relación positiva con el deterioro cognitivo (odds ratio [OR]=9,067; intervalo de confianza del 95% [IC 95%] 1,3056-2,979; p=0,026). Sin embargo, el plazo de interacción y la edad del tabaquismo actual guardan una relación negativa con el deterioro cognitivo (OR=0,969; IC 95% 0,939-0,999; p=0,045). La regresión logística estratificada reflejó que en el subestrato de 40 a 65 años, la OR del tabaquismo actual es de 1,966 (p=0,044), mientras que en el subestrato >65 años, la OR es de 0,470 (p=0,130). Esto significa que la asociación entre el tabaquismo actual y el deterioro cognitivo con la edad podría ser positiva (OR>1) en los subestratos de menor edad, aunque no existe una diferencia significativa en subestratos de mayor edad.

Conclusiones

En conclusión, el tabaquismo actual podría estar positivamente asociado al deterioro cognitivo en la edad mediana, aunque dicha relación disminuye con el incremento de la edad.

Palabras clave:
Tabaquismo actual
Deterioro cognitivo
Edad
Estudio transversal

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