Buscar en
Gastroenterología y Hepatología
Toda la web
Inicio Gastroenterología y Hepatología Fallo hepático agudo en un paciente con tricoleucemia
Información de la revista
Vol. 30. Núm. 6.
Páginas 338-339 (Junio 2007)
Descargar PDF
Más opciones de artículo
Vol. 30. Núm. 6.
Páginas 338-339 (Junio 2007)
DOI: 10.1157/13107568
Acceso a texto completo
Fallo hepático agudo en un paciente con tricoleucemia
Acute liver failure in a patient with hairy cell leukemia
Beatriz Valeroa, M Dolores Picó Salab, José María Palazónb, Artemio Payác
a Servicio de Medicina Interna. Hospital General Universitario de Alicante. Servicio de Aparato Digestivo. Alicante. Espa??a.
b Servicio de Hepatolog??a. Hospital General Universitario de Alicante. Servicio de Aparato Digestivo. Alicante. Espa??a.
c Servicio de Anatom??a Patol??gica. Hospital General Universitario de Alicante. Servicio de Aparato Digestivo. Alicante. Espa??a.
Información del artículo
Texto completo
Descargar PDF
Tablas (1)
Figuras (1)
La infiltración hepática en las neoplasias hematológicas es frecuente, pero el desarrollo de insuficiencia hepática aguda secundaria es una manifestación poco común, con un pronóstico grave. La leucemia de células peludas (tricoleucemia) es un tipo de trastorno linfoproliferativo de células B poco frecuente, que representa alrededor del 2% de todas las leucemias. Vamos a describir el caso de un varón de 78 años de edad, diagnosticado de tricoleucemia, de 10 años de evolución, que presentó una insuficiencia hepática aguda secundaria a la infiltración hepática masiva por su enfermedad hematológica. Hemos realizado una búsqueda bibliográfica en MEDLINE desde 1980 hasta 2006 sobre casos de infiltración hepática por enfermedades hematológicas, y tan sólo hemos encontrado un caso de hepatitis fulminante en el contexto de un paciente con leucemia de células peludas.
Acute liver failure as a manifestation of primary non-Hodkin's lymphoma is a rare phenomenon with a fatal prognosis. Hairy cell leukemia (HCL) is an uncommon chronic B-cell lymphoproliferative disorder, representing about 2 percent of all leukemies. We report a 78-year-old patient with a history of hairy cell leukemia since 10 years, presenting whith fulminant liver failure due to massive liver infiltration. He have reviewed several cases of infiltration of the liver by haematological malignancies, but we only have found after a review in MEDLINE between 1980 and 2006, one case of acute liver failure in a patient with hepatic invasion by hairy cell leukaemia.
Texto completo


A 78-year-old man with a ten-year history of HCL, a silent clinic, without treatment required. He was in treatment with digoxin, acenicumarol, diltiazem and flutamide for a prostatic cancer.

The day of admission the patient was found to be lethargic and weak. Few days after the patient developed asthenia. In his physical exam he was found to be orientated, bradipsiquie, scleral ictericus, blood presure of 124/96 mmHg, and a temperature of 38.2 ºC. The abdomen was painful, overcoat in right side, with splenomegaly.

Admisión laboratory tests showed creatinine 1.7 mg/dl, blood urea nitrogen 49.2 mg/dl, sodium 129 mmol/l, potassium 4.4 mmol/l, calcium 7.4 mg/dl, total bilirubin 3.6 mg/dl, direct bilirubin 1.7 mg/dl, aspartate aminotransferase 1151 U/l, alanine aminotransferase 799 U/l, PCR 7.5 mg/dl, white blood cells 8530/µl, hemoglobin 8.3 g/dl, platelets 67,000/µl, partial thromboplastin time 96.6 sec, INR 4.69, IQ 18%. Previously he had normal liver enzymes. Hemocultures at the day of admission, as well as serologic tests for hepatitis A, B, C, cytomegalovirus, Epstein-Barr virus, VIH, herpes simplex, measles, Coxiella burnetti, rubella, toxoplasma and varicela were negative. Ultrasonographic and TC scan showed a normal liver size with an increased echogenicity of parenchyma and a splenomegaly of 22-24 cm.

Since the first day of admission we observed an acute clinic and analytic deterioration (table I), despite red blood cells and plasma transfussion, vitamin K, antibiotics, and vasoactive drugs. Coma and death followed three days after the initial of symptoms and liver failure. A postmortem hepatic biopsy was obtained (fig. 1).

Fig. 1. Liver infliltration by hairy cell leukemia.


Fulminant hepatic failure carries a high mortality. It can result from a wide variety of causes, among which viral or toxin-induced hepatitis are the most common. Other less frequent etiologies are vascular causes, metabolic disorders, malignant infiltration of the liver, sepsis, heat stroke and autoimmune hepatitis1. We rejected a viral hepatitis by serologic tests. He was in treatment with flutamide since two years and diltiazem2,3. There are several cases of hepatotoxity due to these drugs. There are a few reports of acute hepatic injury including granulomatous hepatitis with the use of diltiazem. In the review made by Wysowski et al4 the post-mortem examination of the liver showed massive hepatocellular necrosis, collapse of lobules, ductal proliferation, and cholestasis without inflammatory cells. The findings in the liver biopsy in our patient were not compatible with these alterations.

Hepatic invasion by malignant lymphoma frequently affect the liver, but it is a rare cause of liver failure and usually has a fatal prognosis5-8. We only have found after a review one case of acute liver failure in a patient with hepatic invasion by HCL9. As in this case, acute advanced liver failure and death shortly after the onset of symptom. Liver biopsy of both demonstrated extensive portal and intralobular hairy cell infiltration with loss of normal architecture. Shehab et al10 have made a review of 23 cases of acute liver failure due to infiltration of the liver by hemotologic malignancies. All presented a clinic and biochemistry presentation compatible, without previous hepatic pathology and confirmation of microscopic infiltration of the hepatic sinusoids. The median survival is about 11 days. In another review of 25 similar patients, the average time of survival was about 7.8 days10.

Furthermore ischemia and injury due to cytokines released have been proposed as the mechanism responsible. TNF-*, interleukin (IL-1, IL-2, IL-6) and several eicosanoids active neutrophiles, endothelial cells of the sinusoids hepatic and kupffer cells induced necrosis of the hepatocytes11-13.

In conclusion, the association between HCL and acute liver failure is unusual, otherwise there are several mechanims, as ischemia and release of cytokines, that can explain something more than a coincidence.

Ostapowicz G, Fontana RJ, Schiodt FV, et al..
Acute Liver Failure Study Group. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States..
Ann Intern Med, 137 (2002), pp. 947-54
Shallcross H, Padley SP, Glynn MJ, et al..
Fatal renal and hepatic toxicity after treatment with diltiazem..
Br Med J (Clin Res Ed), 295 (1987), pp. 1236-7
Traverse JH, Swenson LJ, McBride JW..
Acute hepatic injury after treatment with diltiazem..
Am Heart J, 127 (1994), pp. 1636-9
Wysowski DK, Freiman JP, Tourtelot JB, et al..
Fatal and nonfatal hepatotoxicity associated with flutamide..
Ann Intern Med, 118 (1993), pp. 860-4
Offermann MK, Golomb HM..
Hairy cell leukemia..
Curr Probl Cancer, 8 (1984), pp. 1-39
Wysowski DK, Freiman JP, Tourtelot JB, et al..
Fatal and nonfatal hepatotoxicity associated with flutamide..
Ann Intern Med, 118 (1993), pp. 860-4
Yam LT, Janckila AJ, Chan CH, et al..
Hepatic involvement in hairy cell leukemia..
Cancer, 51 (1983), pp. 1497-504
Vardiman JW, Golomb HM..
Autopsy findingsin hairy cell leukemia..
Semin Oncol, 11 (1984), pp. 370-80
Evans MA, Gastineau DA, Ludwig J..
Relapsing hairy cell leukemia presenting as fulminant hepatitis..
Am J Med, 92 (1992), pp. 209-12
Shehab TM, Kaminski MS, Lok AS..
Acute liver failure due to hepatic involvement by hematologic malignancy..
Dig Dis Sci, 42 (1997), pp. 1400-5
Myszor MF, Record CO..
Primary and secondary malignant disease of the liver and fulminant hepatic failure..
J Clin Gastroenterol, 12 (1990), pp. 441-6
Wolf GM, Petrovic LM, Rojter SE, et al..
Acute liver failure due lymphoma..
Dig Dis Sci, 39 (1994), pp. 1351-8
Ortega J, López J..
Acute liver failure due to T cell lymphoma without hepatic infiltration..
An Esp Pediatr, 58 (2003), pp. 59-62
Opciones de artículo
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

es en pt
Política de cookies Cookies policy Política de cookies
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.