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Inicio Enfermedades Infecciosas y Microbiología Clínica Observations on “Native valve endocarditis caused by Kocuria kristinae”
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Vol. 36. Núm. 2.
Páginas 146 (Febrero 2018)
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Vol. 36. Núm. 2.
Páginas 146 (Febrero 2018)
Letter to the Editor
DOI: 10.1016/j.eimc.2017.08.010
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Observations on “Native valve endocarditis caused by Kocuria kristinae
Observaciones sobre “Endocarditis nativa de la válvula causada por Kocuria kristinae
Gurmeet Ram Rahima, Neha Guptaa,
Autor para correspondencia

Corresponding author.
, Puneet Maheshwarib
a Microbiology department, Shah SatnamJi Speciality Hospitals, Sirsa, Haryana, India
b Department of Anaesthesia, Shah SatnamJi Speciality Hospitals, Sirsa, Haryana, India
Contenido relaccionado
Enferm Infecc Microbiol Clin. 2018;36:14710.1016/j.eimc.2017.09.010
Angel Robles Marhuenda
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With reference to article “Native valve endocarditis caused by Kocuria kristinae” by Angel Robles et al.,1 it was claimed as theirs being the first case of Kocuria kristinae infection associated with native valve endocarditis. However, after search in article engines like Medline, Pubmed, Researchgate, it was found that the first case of Kocuria kristinae endocarditis was reported in 2011 by Lai et al.2 Thereafter, few more reports have been published in 2013(Citro et al.3 and Bastidas et al.4), another one in 2015 by Horino et al.5 All these published reports are cases of native valve endocarditis. The authors agree to the fact that Kocuria kristinae endocarditis although rarely reported is worth mentioning. The steadily rising number of reports bring forth the implications of Kocuria kristinae as a possible etiological agent of native valve endocarditis.

Although limited in number, Kocuria kristinae has increasingly been reported to be associated with systemic infections contrary to the claim made by Angel Robles et al.1 Approximately 24 cases of Kocuria kristinae bacteremia have been reported in literature so far. Kocuria kristinae although considered non-pathogenic, has the potential of causing pathogenic systemic infections.

No antibiotic sensitivity guidelines exist for Kocuria kristinae as of now. After a review of all reported cases published so far in literature, Kocuria kristinae has been found completely sensitive to gentamicin, cotrimoxazole, linezolid, ciprofloxacin and levofloxacin. However, it has been mostly sensitive to vancomycin, erythromycin, clindamycin, teicoplanin, rifampicin and oxacillin with resistance seen in a few cases. Mixed results of sensitivity have been obtained with amikacin, penicillin, ampicillin, ceftriaxone and cefazolin. The outcomes of treatment regimens used, in reported cases so far, have mostly been favorable.

To conclude, Kocuria kristinae that has been considered as a commensal in past, should be acknowledged in cases dealing with systemic infections. More accurate techniques are required to diagnose this organism and differentiate from Coagulase-negative Staphylococci in countries with limited resources. The authors also recommend the formulation of antibiotic guidelines for this organism keeping in mind the rising incidences of Kocuria kristinae infections.

Conflicts of interest

The authors declare that no conflicts of interest exist.


The authors would like to acknowledge Dr.Gurmeet Ram Rahim for His valuable guidance and inspiration in this scientific research.

A. Robles-Marhuenda, M.P. Romero-Gómez, J. García-Rodríguez, F. Arnalich-Fernández.
Native valve endocarditis caused by Kocuria kristinae.
Enferm Infecc Microbiol Clin, 34 (2016), pp. 464-465
C.C. Lai, J.Y. Wang, S.H. Lin, C.K. Tan, C.Y. Wang, C.H. Liao, et al.
Catheter-related bacteraemia and infective endocarditis caused by Kocuria species.
Clin Microbiol Infect, 17 (2011), pp. 190-192
R. Citro, C. Prota, L. Greco, M. Mirra, A. Masullo, A. Silverio, et al.
Kocuria kristinae endocarditis related to diabetic foot infection.
J Med Microbiol, 62 (2013), pp. 932-934
A.R. Bastidas, C.A. Vélez, M. Gutiérrez, N. Bahamón.
Bacterial endocarditis by Kocuria kristinae in an immunocompetent patient: case report.
Rev Colomb Cardiol, 20 (2013), pp. 316-319
T. Horino, Y. Shimamura, K. Ogata, K. Inoue, Y. Terada.
Kocuria kristinae septic arthritis associated with infectious endocarditis in a hemodialysis patient with diabetes mellitus: a case report and literature review.
Renal Replacement Ther, 2 (2016),
Copyright © 2017. Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica
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