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Vol. 49. Núm. 10.
Páginas 325-331 (Diciembre 2002)
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Vol. 49. Núm. 10.
Páginas 325-331 (Diciembre 2002)
Acceso a texto completo
Utilidad de la ultrasonografía endoscópica (USE) en la evaluación prequirúrgica de los tumores neuroendocrinos
Utility Of Endoscopic Ultrasonography (Eus) In The Presurgical Evaluation Of Neuroendocrine Tumors
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5017
L. Argüelloa,
Autor para correspondencia
larguellov@meditex.ex

Correspondencia: Dra. L. Argüello. Unidad de Endoscopias. Servicio de Medicina Digestiva. Hospital La Fe. Avda. Campanar, 21. 46009 Valencia. España.
, A. Ginèsb, M. Pelliséb, V. Ponsa, J.M. Bordasb
a Servicio de Gastroenterología. Hospital Universitario La Fe. Valencia. España
b Unidad de Endoscopia Digestiva. Institut de Malalties Digestives. Hospital Clínic. IDIBAPS. Barcelona. España
Este artículo ha recibido
Información del artículo

Los tumores neuroendocrinos son un proceso patológico infrecuente y de difícil diagnóstico. Su pequeño tamaño y su localización, principalmente en el páncreas o en la pared gastroduodenal, hacen que habitualmente no sean visibles con las técnicas de imagen convencional (ecografía percutánea y tomografía computarizada [TC]). Se han utilizado diversas técnicas de imagen en la localización de estos tumores: resonancia magnética nuclear (RMN), arteriografía, escintigrafía. En este artículo revisamos el papel de la ultrasonografía endoscópica (USE) o ecoendoscopia en la localización de estos tumores. La USE es capaz de visualizar detalladamente todo el páncreas y la pared gastroduodenal, lo que permite la localización y la determinación de la extensión locorregional del tumor. Además la posibilidad de realizar punción aspirativa con aguja fina (PAAF) mediante USE permite obtener el diagnóstico histológico e inmunohistoquímico de confirmación.

Palabras clave:
Ultrasonografía endoscópica
Tumores neuroendocrinos

Neuroendocrine tumors are rare lesions that are frequently difficult to diagnose. Because of their small size and their localization, mainly in the pancreas or the gastric and duodenal wall, they are often not visible with conventional imaging procedures (percutaneous ultrasonography and computed tomography). Several imaging modalities such as magnetic resonance, angiography and scintigraphy have been used to identify these tumors. We review the role of endoscopic ultrasonography (EUS) in the localization of these tumors. EUS allows detailed visualization of the entire pancreas and gastric and duodenal wall, providing localization and determination of local tumour invasion. Furthermore, EUS allows fine needle aspiration to be performed for cytologic and immunohistochemical diagnosis.

Key words:
Endoscopic ultrasonography
Neuroendocrine tumors
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Biblografía
[1.]
D. Al-Musawi, C.N. Williamson.
Endocrine tumours of the pancreas.
Pancreatic disease. Towards the year 2000, pp. 253-263
[2.]
I.M. Modlin, L.H. Tang.
Approaches to the diagnosis of gut neuroendocrine tumors: the last word (today).
Gastroenterol, 112 (1997), pp. 583-590
[3.]
I.M. Modlin, A. Sandor.
An analysis of 8305 cases of carcinoid tumors.
Cancer, 75 (1997), pp. 813-829
[4.]
C.J. Guilligan, G.P. Lawton, L.H. Tang, A.B. West, I.M. Modlin.
Gastric carcinoids tumors: the biology and therapy of an enigmatic and controversial lesion.
Am J Gastroenterol, 90 (1995), pp. 338-352
[5.]
M. Rothmund, L. Angelini, M. Brunt, J.R. Farndon, G. Geelhoed, D. Grama.
Surgery for bening insulinoma: an international review.
World J Surg, 14 (1990), pp. 393-399
[6.]
R.T. Jensen.
Overview of chronic diarrhea caused by functional neuroendocrine neoplasms.
Semin Gastrointest Dis, 10 (1999), pp. 156-172
[7.]
A.R. Moosa, B.E. Stabile.
Vipoma.
Essential surgical practice 3rd ed, pp. 1274-1275
[8.]
Y. Haga, H. Yanagi, J. Urata, M. Inada, S. Shimada, N. Nitahata, et al.
Early detection of pancreatic glucagonoma.
Am J Gastroenterol, 90 (1995), pp. 2216-2223
[9.]
C. Mao, J.M. Howard.
Pancreatitis associated with neuroendocrine (islet cell) tumours of the pancreas.
Am J Surg, 171 (1996), pp. 562-564
[10.]
T. Zimmer, U. Stölzel, M. Bäder, K. Koppenhagen, B. Hamm, H. Buhr, et al.
Endoscopic ultrasonography and somatostatin receptor scintigraphy in the preoperative localisation of insulinomas and gastrinomas.
Gut, 39 (1996), pp. 562-568
[11.]
S.R. Wise, J. Johnson, J. Sparks, L.C. Carey, E.C. Ellison.
Gastrinoma: the predictive value of pre-operative localisation.
Surgery, 106 (1989), pp. 1087-1093
[12.]
T. Zimmer, K. Ziegler, M. Bäder, U. Fett, B. Hamm, E-O Riecken, et al.
Localisation of neuroendocrine tumours of the upper gastrointestinal tract.
Gut, 35 (1994), pp. 471-475
[13.]
H. Scherübl, M. Bäder, U. Fett, B. Hamm, H. Schmidt-Gayk, K. Koppenhagen, et al.
Somatostatin-receptor imaging of neuroendocrine gastroenteropancreatic tumors.
Gastroenterol, 105 (1993), pp. 1705-1709
[14.]
J.R. Pisegna, J.L. Doppman, J.A. Norton, D.C. Metz, R.T. Jensen.
Prospective comparative study of ability of MR imaging modalities to localize tumors in patients with Zollinger-Ellison syndrome.
Dig Dis Sci, 38 (1993), pp. 1318-1328
[15.]
G.M. Doherty, J.L. Doppman, T.H. Shawker, D.L. Miller, R.C. Eastman, P. Gorden, et al.
Results of a prospective strategy to diagnose, localize and resect insulinomas.
Surgery, 110 (1991), pp. 989-997
[16.]
A.K. Thom, J.A. Norton, J.L. Doppman, D.L. Miller, R. Chang, R.T. Jensen.
Prospective study of the use of intraarterial secretin injection and portal venous sampling to localize duodenal gastrinomas.
Surgery, 112 (1992), pp. 1002-1009
[17.]
J.L. Doppman, R. Chang, D.L. Fraker, J.A. Norton, H.R. Alexander, D.L. Miller, et al.
Localization of insulinomas to regions of the pancreas by intra-arterial stimulation with calcium.
Ann Intern Med, 123 (1995), pp. 269-273
[18.]
J.L. Doppman, D.L. Miller, R. Chang, T.H. Shawker, P. Gorden, J.A. Norton.
Insulinomas: localization with selective intraarterial injection of calcium.
Radiology, 178 (1991), pp. 237-241
[19.]
D.L. Miller, J.L. Doppman, D.C. Metz, P.N. Maton, J.A. Norton, R.T. Jensen.
Zollinger-Ellison syndrome: technique, results and complications of portal venous sampling.
Radiology, 182 (1992), pp. 235-241
[20.]
F. Gibril, J.C. Reynolds, J.L. Doppman, C.C. Chen, D.J. Venzon, B. Termanini, et al.
Somatostatin receptor scintigraphy: its sensitivity compared with that of other imaging methods in detecting primary and metastatic gastrinomas.
Ann Intern Med, 125 (1996), pp. 26-34
[21.]
E.P. Krenning, D.J. Kwekkeboom, H.Y. Oei, R.J.B. De Jong, F.J. Dop, W.W. De Herder, et al.
Somatostatin receptor scintigraphy in carcinoids, gastrinomas and Cushing's syndrome.
Digestion, 55 (1994), pp. 54-59
[22.]
G. Cadiot, R. Lebtahi, L. Sarda, G. Bonnaud, J.P. Marmuse.
Vissuzaine C, et al and Groupe d'etude du syndrome de Zollinger-Ellison. Preoperative detection of duodenal gastrinomas and peripancreatic lymph nodes by somatostatin receptor scintigraphy.
Gastroenterol, 111 (1996), pp. 845-854
[23.]
R.J. Weinel, C. Neuhaus, J. Stapp, H.J. Klotter, M.E. Trautmann, K. Joseph, et al.
Preoperative localization of gastrointestinal endocrine tumors using somatostatin-receptor scintigraphy.
Ann Surg, 218 (1993), pp. 640-645
[24.]
M. Raderer, A. Kurtaran, M. Leimer, P. Angelberger, B. Niederle, H. Vierhapper, et al.
Value of peptide receptor scintigraphy using123 I-vasoactive intestinal peptide and 111In-DTPA-D-Phe1-octeotride in 194 carcinoid patients: Vienna University experience, 1993 to 1998.
J Clin Oncol, 18 (2000), pp. 1331-1336
[25.]
E.P. Krenning, D.J. Kwekkeboom, W.H. Bakker, W.A. Breeman, P.P. Kooij, H.Y. Oei, et al.
Somatostatin receptor scintigraphy with (111In-DTPA-D-Phe1) and (123I-Tyr3) octeotride: the Rotterdam experience with more than 1000 patients.
Eur J Nucl Med, 20 (1993), pp. 716-731
[26.]
P. Ruszniewski, P. Amouyal, G. Amouyal, J-D Grangè, M. Mignon, O. Bouché, et al.
Localization of gastrinomas by endoscopic ultrasonography in patients with Zollinger-Ellison syndrome.
Surgery, 117 (1995), pp. 629-635
[27.]
J.R. Glover, P.J. Shorvon, W.R. Lees.
Endoscopic ultrasound for localisation of islet cell tumours.
Gut, 33 (1992), pp. 108-110
[28.]
R. Bansal, W. Tierney, S. Carpenter, N. Thompson, M. Scheiman.
Cost effectiveness of EUS for preoperative localization of pancreatic endocrine tumors.
Gastrointest Endosc, 49 (1999), pp. 19-25
[29.]
T. Rösch, R. Lorenz, C. Braig, S. Feuerbach, J.R. Siewert, V. Schusdziarra, et al.
Endoscopic ultrasound in pancreatic tumor diagnosis.
Gastrointest Endosc, 37 (1991), pp. 347-352
[30.]
O. Keriven-Souquet, J.C. Souquet, T. Ponchon, B. Napoléon, B. Pujol.
Endoscopic ultrasound for the diagnosis of pancreatic cancer: prospective study in 52 patients with non informative abdominal ultrasound.
Gastrointest Endosc, 41 (1995), pp. A519
[31.]
L. Palazzo, G. Rouseau, M. Salermon.
Endoscopic ultrasonography in the preoperative localisation of pancreatic endocrine tumours.
Endoscopy, 24 (1992), pp. 350-353
[32.]
L. Palazzo, E. Borrotto, B. Napoleon, B. Pujol, G. Roseau, R. Gimbaud, et al.
Is endoscopic ultrasonography accurate for the localization of pancreatic and duodenal tumors in patients with multiple endocrine neoplasia type I?.
Gastroenterology, 106 (1994), pp. A313
[33.]
J. Pitre, O. Soubrane, L. Palazzo, Y. Chapuis.
Endoscopic ultrasound for the preoperative localization of insulinomas.
Pancreas, 13 (1996), pp. 55-60
[34.]
T. Rösch, C.J. Lightdale, J.F. Botet, G.A. Boyce, M.V. Sivak Jr, K. Yasuda, et al.
Localization of pancreatic endocrine tumors by endoscopic ultrasonography.
N Engl J Med, 326 (1992), pp. 1721-1726
[35.]
R. Oncins, B. De Escalante, J. Villalta, J. Candeal, Y. Harb, F. Riu.
Tumor carcinoide gástrico. Estudio clínico-patológico e inmunohistoquímico de cuatro casos.
Rev Esp Enf Dig, 89 (1997), pp. 611-615
[36.]
N.W. Thompson, P.F. Czako, L.L. Fritts, R. Bude, R. Bansal, T.T. Nostrant, et al.
Role of endoscopic ultrasonography in the localization of insulinomas and gastrinomas.
Surgery, 116 (1994), pp. 1131-1138
[37.]
M.J. Wiersema, P. Vilmann, M. Giovannini, K. Chang.
Endosonographic-guided fine needle aspiration biopsy: diagnostic accuracy and complication assesmant.
Gastroenterol, 112 (1997), pp. 1087-1095
[38.]
M. Voss, P. Hammel, G. Molas, L. Palazzo, A. Dancour, D. O'Toole, et al.
Value of endoscopic ultrasound guided fine needle aspiration biopsy in the diagnosis of solid pancreatic masses.
Gut, 46 (2000), pp. 244-249
[39.]
D.B. Williams, A.V. Sahai, L. Aabakken, I.D. Penman, A. Van Velse, J. Webb, et al.
Endoscopic ultrasound guided fine needle aspiration biopsy: a large single centre experience.
Gut, 44 (1999), pp. 720-726
[40.]
K.J. Chang, P. Nguyen, R.A. Erickson, T.E. Durbin, K.D. Katz.
The clinical utility of endoscopic ultrasound-guided fine-needle aspiration in the diagnosis and staging of pancreatic carcinoma.
Gastrointest Endosc, 45 (1997), pp. 387-393
[41.]
M.S. Bhutani, R.H. Hawes, P.L. Baron, A. Sanders-Cliette, A. Van Velse, J.F. Osborne, et al.
Endoscopic ultrasound guided fine aspiration of malignant pancreatic lesions.
Endosc, 29 (1997), pp. 854-858
[42.]
A. Ginès, E. Vázquez-Sequeiros, M.T. Soria, J.E. Clain, M.J. Wiersema.
Usefulness of endoscopic ultrasound guided fine-aspiration biopsy (EUS-FNA) in the diagnosis of neuroendocrine tumors not visualized by other imaging modalities.
Gastrointest Endosc, 56 (2002), pp. 291-296
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