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Vol. 52. Núm. 10.
Páginas 556-563 (Diciembre 2005)
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Vol. 52. Núm. 10.
Páginas 556-563 (Diciembre 2005)
Revisión
DOI: 10.1016/S1575-0922(05)71064-0
Acceso a texto completo
Consumo de café y diabetes mellitus
Coffee consumption and diabetes mellitus
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G. Rojo-Martínez??
Autor para correspondencia
gemma.rojo.exts@juntadeandalucia.es

Correspondencia: Dra. G. Rojo-Martínez. Laboratorio de Investigación. Servicio de Endocrinología y Nutrición. Pabellón 5. Sótano. Hospital Civil. Hospital Universitario Carlos Haya. Pl. Hospital Civil, s/n. 29009 Málaga. España.
, S. Morcillo, M.C. Almaraz, F. Soriguer
Servicio de Endocrinología y Nutrición. Hospital Civil. Hospital Universitario Carlos Haya. Málaga. España.
Información del artículo
Resumen
Bibliografía
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Desde hace muchos años se ha estudiado la relación entre el consumo de café y diversas enfermedades, principalmente cardiovasculares y cáncer, pero también enfermedades psiquiátricas y, más recientemente, relación con la diabetes mellitus.

En este trabajo revisaremos los datos disponibles sobre la relación entre el café y el riesgo de presentar diabetes, con una breve referencia a la relación del café con las enfermedades cardiovasculares.

Los trabajos sobre la relación entre la ingesta de café y la presencia de diabetes son divergentes, ya que, mientras algunos grandes estudios de cohortes parecen indicar un efecto protector sobre la aparición de diabetes mellitus, los estudios de intervención (todos a corto plazo) suelen demostrar un efecto deletéreo sobre el metabolismo glucídico. Las relaciones entre el consumo de café y el riesgo de presentar diabetes mellitus están lejos de establecerse definitivamente. Posiblemente, la relación entre el consumo de café y la salud esté condicionada no solo por la presencia de sustancias bioactivas en el café –que además poseen efectos opuestos sobre el metabolismo glucídico, por ejemplo–, sino también por la forma de preparar la bebida (filtrado, hervido, expreso, instantáneo, natural o torrefacto…) que altera su composición final, y por otro lado por la asociación entre el consumo de café y otros hábitos dietéticos o no (ingesta de alcohol, tabaquismo, actividad física, incluso costumbre de dormir la siesta) que pueden influir de manera directa en los aspectos de la salud en los que también parecen influir los componentes del café.

Palabras clave:
Café
Cafeína
Diabetes mellitus
Ácido clorogénico
Antioxidantes

The association between coffee consumption and various diseases, mainly cardiovascular diseases and cancer but also psychiatric disorders and, more recently, diabetes mellitus, has been investigated for many years.

In the present article, we review the evidence available on the association between coffee intake and the risk of diabetes and briefly review the association between coffee intake and cardiovascular disease.

Studies on the association between coffee intake and diabetes report contradictory results; while some large cohort studies seem to indicate a protective effect against the development of diabetes mellitus, intervention studies (all short-term) usually demonstrate a harmful effect on glucose metabolism.

The association between coffee consumption and the risk of diabetes mellitus is far from being definitively established. The relationship between coffee intake and health may be influenced not only by the presence of bioactive substances in coffee (which, moreover, have opposite effects on glucose metabolism, for example) but also by the way the beverage is prepared (filtered, boiled, express, instant, natural or darkroasted…),which affects its final composition. The relationship between coffee consumption and other dietary and health-related factors (alcohol intake, smoking, physical activity, even the habit of taking an afternoon nap) may also be of influence. These factors may have a direct effect on the aspects of health influenced by the components of coffee.

Key words:
Coffee
Caffeine
Diabetes mellitus
Chlorogenic acid
Antioxidants
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Bibliografía
[1.]
A. Gutierrez.
Café, antioxidantes y protección de la salud.
Medisan, 6 (2002), pp. 72-81
[2.]
K.J. Mukamal, M. Maclure, J.E. Muller, J.B. Sherwood, M.A. Mittleman.
Caffeinated coffee consumption and mortality after acute myocardial infarction.
Am Heart J, 147 (2004), pp. 999-1004
[3.]
C. La Vecchia, B. D’Avanzo, E. Negri, S. Franceschi, A. Gentile, A. Tavani.
Decaffeinated coffee and acute myocardial infarction. A case-control study in Italian women.
Ann Epidemiol, 3 (1993), pp. 601-604
[4.]
D.B. Panagiotakos, C. Pitsavos, C. Chrysohoou, P. Kokkinos, P. Toutouzas, C. Stefanadis.
The J-shaped effect of coffee consumption on the risk of developing acute coronary syndromes: the CARDIO2000 case-control study.
J Nutr, 133 (2003), pp. 3228-3232
[5.]
L. El-Khairy, P.M. Ueland, O. Nygard, H. Refsum, S.E. Vollset.
Lifestyle and cardiovascular disease risk factors as determinants of total cysteine in plasma: the Hordaland Homocysteine Study.
Am J Clin Nutr, 70 (1999), pp. 1016-1024
[6.]
O. Nygard, H. Refsum, P.M. Ueland, I. Stensvold, J.E. Nordrehaug, G. Kvale, et al.
Coffee consumption and plasma total homocysteine: The Hordaland Homocysteine Study.
Am J Clin Nutr, 65 (1997), pp. 136-143
[7.]
R. Urgert, A.G. Schulz, M.B. Katan.
Effects of cafestol and kahweol from coffee grounds on serum lipids and serum liver enzymes in humans.
Am J Clin Nutr, 61 (1995), pp. 149-154
[8.]
P. Happonen, S. Voutilainen, J.T. Salonen.
Coffee drinking is dose-dependently related to the risk of acute coronary events in middle-aged men.
J Nutr, 134 (2004), pp. 2381-2386
[9.]
A. Tavani, M. Bertuzzi, S. Gallus, E. Negri, C. La Vecchia.
Risk factors for non-fatal acute myocardial infarction in Italian women.
Prev Med, 39 (2004), pp. 128-134
[10.]
K.J. Mukamal, M. Maclure, J.E. Muller, J.B. Sherwood, M.A. Mittleman.
Caffeinated coffee consumption and mortality after acute myocardial infarction.
Am Heart J, 147 (2004), pp. 999-1004
[11.]
H.D. Sesso, J.M. Gaziano, J.E. Buring, C.H. Hennekens.
Coffee and tea intake and the risk of myocardial infarction.
Am J Epidemiol, 149 (1999), pp. 162-167
[12.]
E. Casiglia, P. Mormino, P. Spolaore, O. Maschio, C. Cernetti, F. Costa, et al.
Cardiovascular effects of coffee consumption in the aged: the CASTEL epidemiologic study.
Cardiologia, 35 (1990), pp. 827-832
[13.]
R.M. Van Dam, E.J. Feskens.
Coffee consumption and risk of type 2 diabetes mellitus.
Lancet, 360 (2002), pp. 1477-1478
[14.]
A. Reunanen, M. Heliovaara, K. Aho.
Coffee consumption and risk of type 2 diabetes mellitus.
[15.]
A. Saremi, M. Tulloch-Reid, W.C. Knowler.
Coffee consumption and the incidence of type 2 diabetes.
Diabetes Care, 26 (2003), pp. 2211-2212
[16.]
E. Salazar-Martínez, W.C. Willett, A. Ascherio, J.E. Manson, M.F. Leitzmann, M.J. Stampfer, et al.
Coffee consumption and risk for type 2 diabetes mellitus.
Ann Intern Med, 140 (2004), pp. 1-8
[17.]
J. Tuomilehto, G. Hu, S. Bidel, J. Lindstrom, P. Jousilahti.
Coffee consumption and risk of type 2 diabetes mellitus among middle-aged Finnish men and women.
JAMA, 291 (2004), pp. 1213-1219
[18.]
S.M. Virtanen, L. Rasanen, A. Aro, K. Ylonen, R. Lounamaa, H.K. Akerblom, et al.
Is children's or parents’ coffee or tea consumption associated with the risk for type 1 diabetes mellitus in children? Childhood Diabetes in Finland Study Group.
Eur J Clin Nutr, 48 (1994), pp. 279-285
[19.]
S.H. Jee, J. He, L.J. Appel, P.K. Whelton, I. Suh, M.J. Klag.
Coffee consumption and serum lipids: a meta-analysis of randomized controlled clinical trials.
Am J Epidemiol, 153 (2001), pp. 353-362
[20.]
F. Soriguer, G. Rojo-Martínez, I. Esteva.
Coffee consumption and type 2 diabetes mellitus.
Ann Intern Med, 141 (2004), pp. 321-323
[21.]
A. Isogawa, M. Noda, Y. Takahashi, T. Kadowaki, S. Tsugane.
Coffee consumption and risk of type 2 diabetes mellitus.
[22.]
E.E. Agardh, S. Carlsson, A. Ahlbom, S. Efendic, V. Grill, N. Hammar, et al.
Coffee consumption, type 2 diabetes and impaired glucose tolerance in Swedish men and women.
J Intern Med, 255 (2004), pp. 645-652
[23.]
J. Arnlov, B. Vessby, U. Riserus.
Coffee consumption and insulin sensitivity.
JAMA, 291 (2004), pp. 1199-1201
[24.]
A. Rosengren, A. Dotevall, L. Wilhelmsen, D. Thelle, S. Johansson.
Coffee and incidence of diabetes in Swedish women: a prospective 18-year follow-up study.
J Intern Med, 255 (2004), pp. 89-95
[25.]
D.J. Naismith, P.A. Akinyanju, S. Szanto, J. Yudkin.
The effect, in volunteers, of coffee and decaffeinated coffee on blood glucose, insulin, plasma lipids and some factors involved in blood clotting.
Nutr Metab, 12 (1970), pp. 144-151
[26.]
R.M. Van Dam, W.J. Pasman, P. Verhoef.
Effects of coffee consumption on fasting blood glucose and insulin concentrations: randomized controlled trials in healthy volunteers.
Diabetes Care, 27 (2004), pp. 2990-2992
[27.]
O.M. Jankelson, S.B. Beaser, F.M. Howard, J. Mayer.
Effect of coffee on glucose tolerance and circulating insulin in men with maturity-onset diabetes.
Lancet, 1 (1967), pp. 527-529
[28.]
L.J. Feinberg, H. Sandberg, O. De Castro, S. Bellet.
Effects of coffee ingestion on oral glucose tolerance curves in normal human subjects.
Metabolism, 17 (1968), pp. 916-922
[29.]
K.L. Johnston, M.N. Clifford, L.M. Morgan.
Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine.
Am J Clin Nutr, 78 (2003), pp. 728-733
[30.]
D.V. Rodríguez de Sotillo, M. Hadley.
Chlorogenic acid modifies plasma and liver concentrations of: cholesterol, triacylglycerol, and minerals in (fa/fa) Zucker rats.
J Nutr Biochem, 13 (2002), pp. 717-726
[31.]
H. Hemmerle, H.J. Burger, P. Below, G. Schubert, R. Rippel, P.W. Schindler, et al.
Chlorogenic acid and synthetic chlorogenic acid derivatives: novel inhibitors of hepatic glucose-6-phosphate translocase.
J Med Chem, 40 (1997), pp. 137-145
[32.]
T. Matsui, S. Ebuchi, K. Fukui, K. Matsugano, N. Terahara, K. Matsumoto.
Caffeoylsophorose, a new natural alpha-gluco-si-dase inhibitor, from red vinegar by fermented purple-fleshed sweet potato.
Biosci Biotechnol Biochem, 68 (2004), pp. 2239-2246
[33.]
J. Takaya, H. Higashino, Y. Kobayashi.
Intracellular magnesium and insulin resistance.
Magnes Res, 17 (2004), pp. 126-136
[34.]
R. Lopez-Ridaura, W.C. Willett, E.B. Rimm, S. Liu, M.J. Stampfer, J.E. Manson, et al.
Magnesium intake and risk of type 2 diabetes in men and women.
Diabetes Care, 27 (2004), pp. 134-140
[35.]
Y. Song, J.E. Manson, J.E. Buring, S. Liu.
Dietary magnesium intake in relation to plasma insulin levels and risk of type 2 diabetes in women.
Diabetes Care, 27 (2004), pp. 59-65
[36.]
F.L. Hsu, Y.C. Chen, J.T. Cheng.
Caffeic acid as active principle from the fruit of Xanthium strumarium to lower plasma glucose in diabetic rats.
Planta Med, 66 (2000), pp. 228-230
[37.]
P. Nawrot, S. Jordan, J. Eastwood, J. Rotstein, A. Hugenholtz, M. Feeley.
Effects of caffeine on human health.
Food Addit Contam, 20 (2003), pp. 1-30
[38.]
M.L. Nurminen, L. Niittynen, R. Korpela, H. Vapaatalo.
Coffee, caffeine and blood pressure: a critical review.
Eur J Clin Nutr, 53 (1999), pp. 831-839
[39.]
S.H. Jee, J. He, P.K. Whelton, I. Suh, M.J. Klag.
The effect of chronic coffee drinking on blood pressure: a meta-analysis of controlled clinical trials.
Hypertension, 33 (1999), pp. 647-652
[40.]
I. Biaggioni, S.N. Davis.
Caffeine: a cause of insulin resistance?.
Diabetes Care, 25 (2002), pp. 399-400
[41.]
G.B. Keijzers, B.E. De Galan, C.J. Tack, P. Smits.
Caffeine can decrease insulin sensitivity in humans.
Diabetes Care, 25 (2002), pp. 364-369
[42.]
D. Robertson, D. Wade, R. Workman, R.L. Woosley, J.A. Oates.
Tolerance to the humoral and hemodynamic effects of caffeine in man.
J Clin Invest, 67 (1981), pp. 1111-1117
[43.]
F. Greer, R. Hudson, R. Ross, T. Graham.
Caffeine ingestion decreases glucose disposal during a hyperinsulinemic-euglycemic clamp in sedentary humans.
Diabetes, 50 (2001), pp. 2349-2354
[44.]
T.E. Graham, P. Sathasivam, M. Rowland, N. Marko, F. Greer, D. Battram.
Caffeine ingestion elevates plasma insulin response in humans during an oral glucose tolerance test.
Can J Physiol Pharmacol, 79 (2001), pp. 559-565
[45.]
F.S. Thong, T.E. Graham.
Caffeine-induced impairment of glucose tolerance is abolished by beta-adrenergic receptor blockade in humans.
J Appl Physiol, 92 (2002), pp. 2347-2352
[46.]
L.J. Feinberg, H. Sandberg, O. De Castro, S. Bellet.
Effects of coffee ingestion on oral glucose tolerance curves in normal human subjects.
Metabolism, 17 (1968), pp. 916-922
[47.]
J.D. Lane, C.E. Barkauskas, R.S. Surwit, M.N. Feinglos.
Caffeine impairs glucose metabolism in type 2 diabetes.
Diabetes Care, 27 (2004), pp. 2047-2048
[48.]
L.E. Robinson, S. Savani, D.S. Battram, D.H. McLaren, P. Sathasivam, T.E. Graham.
Caffeine ingestion before an oral glucose tolerance test impairs blood glucose management in men with type 2 diabetes.
J Nutr, 134 (2004), pp. 2528-2533
[49.]
H.J. Petrie, S.E. Chown, L.M. Belfie, A.M. Duncan, D.H. McLaren, J.A. Conquer, et al.
Caffeine ingestion increases the insulin response to an oral-glucose-tolerance test in obese men before and after weight loss.
Am J Clin Nutr, 80 (2004), pp. 22-28
[50.]
M. Van Soeren, T. Mohr, M. Kjaer, T.E. Graham.
Acute effects of caffeine ingestion at rest in humans with impaired epinephrine responses.
J Appl Physiol, 80 (1996), pp. 999-1005
[51.]
F.S. Thong, T.E. Graham.
Caffeine-induced impairment of glucose tolerance is abolished by beta-adrenergic receptor blockade in humans.
J Appl Physiol, 92 (2002), pp. 2347-2352
[52.]
F.S. Thong, W. Derave, B. Kiens, T.E. Graham, B. Urso, J.F. Wojtaszewski, et al.
Caffeine-induced impairment of insulin action but not insulin signaling in human skeletal muscle is reduced by exercise.
Diabetes, 51 (2002), pp. 583-590
[53.]
D.M. Kuftinec, J. Mayer.
Extreme sensitivity of obese hyperglycemic mice to caffeine and coffee.
Metabolism, 13 (1964), pp. 1369-1375
[54.]
K. Yoshioka, A. Kogure, T. Yoshida, T. Yoshikawa.
Coffee consumption and risk of type 2 diabetes mellitus.
Lancet, (2003), pp. 361-703
[55.]
C.L. Shi.
Effects of caffeine and acetylcholine on glucose-stimulated insulin release from islet transplants in mice.
Cell Transplant, 6 (1997), pp. 33-37
[56.]
J.D. Bruton, R. Lemmens, C.L. Shi, S. Persson-Sjogren, H. Westerblad, M. Ahmed, et al.
Ryanodine receptors of pancreatic beta-cells mediate a distinct context-dependent signal for insulin secretion.
FASEB J, 17 (2003), pp. 301-303
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