Food anaphylaxis, antiphospholipid syndrome and thrombosis

Dear Editor,

A recent publication on food antiphospholipid syndrome and thrombosis is very interesting.¹ Korkmaz concluded that “seed lipoproteins, which cause severe food anaphylaxis, might have a potential role in the antiphospholipid syndrome and related thrombosis.¹” There are some issues on this report that need to be discussed. The possible problems on design include few subjects, imbalancing between number of cases and controls and no quality control on the laboratory tests. In addition, the author focused on “seed” which does not mean “food”; hence, it cannot answer the question “Is food anaphylaxis a cause of antiphospholipid syndrome and thrombosis or a coincidence?” Confounding factors such as drugs and infections cannot be excluded.