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Vol. 23. Issue 1.
Pages 1-16 (January - April 2022)
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Vol. 23. Issue 1.
Pages 1-16 (January - April 2022)
Special article
Simulator of interactions of the human immune system: Description of the model for the life cycle of human papillomavirus type 16 and therapeutic vaccines
Simulador de interacciones del sistema inmune humano: descripción del modelo para el ciclo de vida del virus de papiloma humano tipo 16 y vacunas terapéuticas
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M.E. Escobar Ospina
Departamento de Ingeniería – Sistemas y Computación, Universidad Nacional, Bogotá, Colombia
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Abstract
Objective

To present an artificial life model that simulates behaviours based on interactions that emerge between the human immune system, the life cycle of human papillomavirus type 16, some types of therapeutic virus type 16, and some types of therapeutic vaccines.

Materials and methods

Using the approach of complex systems theories and biological systems, we created an artificial life model that allowed us to simulate virtual patient immune systems that develop infectious viral processes. These patients receive a therapeutic vaccine capable of releasing the necessary doses autonomously, once the model establishes that the immune system has outgrown its ability to counteract lesions caused by persistent viral infection.

Conclusions

The methodology developed provides independence to the modelling of each of the components that make up each of the components that constitute the three proposed domains and reflects the dynamics that emerge from their interactions, thus ensuring the corresponding feedback processes. With this work, a knowledge base is established that allows us to define the conceptual design, determine the general logic, and produce the dynamics of implementation of the HPV16-ALIFE model.

Keywords:
Artificial life
Artificial immune system
Cervical cancer
Hpv16
Simulation model
Therapeutic vaccine
Resumen
Objetivo

Presentar un modelo de vida artificial que simula comportamientos basados en interacciones que emergen entre el sistema inmune humano, ciclo de vida del virus de papiloma humano tipo 16, y algunos tipos de vacunas terapéuticas.

Materiales y métodos

Bajo el enfoque de teorías de sistemas complejos y sistemas biológicos, creamos un modelo de vida artificial que nos permite simular sistemas inmunes de pacientes virtuales que desarrollan procesos virales infecciosos. Estos pacientes reciben una vacuna terapéutica capaz de liberar las dosis necesarias de forma autónoma, una vez el modelo establece que el sistema inmune ha superado su capacidad de contrarrestar lesiones causadas por la infección viral persistente.

Conclusiones

La metodología desarrollada proporciona independencia al modelamiento de cada uno de los componentes que integran los tres dominios propuestos y refleja la dinámica que surge a partir de sus interacciones, garantizando de esta forma los procesos de retroalimentación correspondientes. Con este trabajo se establece una base de conocimiento que nos permite definir el diseño conceptual, determinar la lógica general, y producir la dinámica de implementación del modelo HPV16-ALIFE.

Palabras clave:
Vida artificial
Sistema inmune artificial
Cáncer cérvix
Hpv16
Modelo simulación
Vacuna terapéutica

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