TY - JOUR T1 - Simulator of interactions of the human immune system: Description of the model for the life cycle of human papillomavirus type 16 and therapeutic vaccines JO - Vacunas (English Edition) T2 - AU - Escobar Ospina,M.E. SN - 24451460 M3 - 10.1016/j.vacune.2022.01.002 DO - 10.1016/j.vacune.2022.01.002 UR - https://www.elsevier.es/en-revista-vacunas-english-edition--259-articulo-simulator-interactions-human-immune-system-S2445146022000048 AB - ObjectiveTo present an artificial life model that simulates behaviours based on interactions that emerge between the human immune system, the life cycle of human papillomavirus type 16, some types of therapeutic virus type 16, and some types of therapeutic vaccines. Materials and methodsUsing the approach of complex systems theories and biological systems, we created an artificial life model that allowed us to simulate virtual patient immune systems that develop infectious viral processes. These patients receive a therapeutic vaccine capable of releasing the necessary doses autonomously, once the model establishes that the immune system has outgrown its ability to counteract lesions caused by persistent viral infection. ConclusionsThe methodology developed provides independence to the modelling of each of the components that make up each of the components that constitute the three proposed domains and reflects the dynamics that emerge from their interactions, thus ensuring the corresponding feedback processes. With this work, a knowledge base is established that allows us to define the conceptual design, determine the general logic, and produce the dynamics of implementation of the HPV16-ALIFE model. ER -